Mismatch between the 1997/1998 influenza vaccine and the major epidemic A (H3N2) virus strain as the cause of an inadequate vaccine-induced antibody response to this strain in the elderly. [PDF]
, 2000 The success of influenza vaccination depends largely on the antigenic match between the influenza vaccine strains and the virus strains actually circulating during the season. In the past, this match has proved to be satisfactory in most seasons.
Beyer, W.E.Ph. (Walter) +4 more
core +2 more sources
Human Vaccines & ImmunotherapeuticsImmune imprinting is a phenomenon that stems from the fundamentals of immunological memory. Upon recurrent exposures to an evolving pathogen, the immune system must weigh the benefits of rapidly recalling established antibody repertoires with greater ...
Mariam Maltseva +3 more
doaj +1 more source
Mouse Models of Heterologous Flavivirus Immunity: A Role for Cross-Reactive T Cells
Frontiers in Immunology, 2019 Most of the world is at risk of being infected with a flavivirus such as dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, tick-borne encephalitis virus, and Zika virus, significantly impacting millions of lives. Importantly,
Mariah Hassert +2 more
doaj +1 more source
, 1971 The purposes of this report are to describe a method of preparing a potent crude pneumococcal hemolysin, to define some of it characteristics, and to describe the effects of its administration to ...
Shumway, Clare N.
core +1 more source
The Borrelia afzelii outer membrane protein BAPKO_0422 binds human Factor-H and is predicted to form a membrane-spanning beta-barrel [PDF]
, 2015 The deep evolutionary history of the Spirochetes places their branch point early in the evolution of the diderms, before the divergence of the present day Proteobacteria.
Adam Dyer +76 more
core +1 more source
Factors determining the outcomes of immune imprinting after repeated orthoflavivirus infections
Frontiers in ImmunologyOrthoflaviviruses, a group of arthropod-borne viruses, represent a significant global health threat, with hundreds of millions of infections each year, often leading to severe clinical outcomes.
Gielenny M. Salem +5 more
doaj +1 more source
A Physical Theory of the Competition that Allows HIV to Escape from the Immune System
, 2006 Competition within the immune system may degrade immune control of viral infections. We formalize the evolution that occurs in both HIV-1 and the immune system quasispecies.
A. K. Abbas +3 more
core +1 more source
Lack of Original Antigenic Sin in Recall CD8+ T Cell Responses [PDF]
The Journal of Immunology, 2010 Abstract In the real world, mice and men are not immunologically naive, having been exposed to numerous antigenic challenges. Prior infections sometimes negatively impact the response to a subsequent infection. This can occur in serial infections with pathogens sharing cross-reactive Ags.
Zehn, D. +3 more
openaire +3 more sources
Original Mycobacterial Sin, a consequence of highly homologous antigens?
Veterinary Microbiology, 2017 The role of antigens shared between Mycobacteria in in-vivo cross-reactive immune responses in host animals, have been reported to be responsible for reduced BCG vaccination efficacy as well reduced specificity of routine immunological diagnostic tests. This presents with significant disease control challenges in humans and animals.
Jenkins, A. O., Michel, A., Rutten, V.
openaire +6 more sources
Genetic diversity and C2-like subgenogroup strains of enterovirus 71, Taiwan, 2008 [PDF]
, 2010 Background Human enterovirus 71 (EV-71) is known of having caused numerous outbreaks of hand-foot-mouth disease, and other clinical manifestations globally. In 2008, 989 EV-71 strains were isolated in Taiwan.
Yang Jyh-Yuan +9 more
core +1 more source