Results 201 to 210 of about 1,504,803 (264)

Patterns and determinants of drug-drug interactions among community-dwelling older adults in Saudi Arabia: a cross-sectional study. [PDF]

Front Pharmacol
Khawagi WY, Aldali JA, Aljohani RM, Alshehri AA.   +3 more
europepmc   +1 more source

Correction: Platelet-membrane-biomimetic nanoparticles for targeted antitumor drug delivery. [PDF]

J Nanobiotechnology
Wang H, Wu J, Williams GR, Fan Q, Niu S, Wu J, Xie X, Zhu LM.   +7 more
europepmc   +1 more source

Analysis of the interaction network relationship between drugs using a graph neural network. [PDF]

Front Pharmacol
Chai Z, Wang J, Du H.
europepmc   +1 more source

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The Origin of Antithyroid Drugs

Thyroid®, 2023
Background: When the antithyroid drugs were discovered in the early 1940s, they were immediately recognized as a revolutionary new treatment for hyperthyroidism. Although much has been learned about their mechanism of action and clinical utility, they continue to be used today in much the same way as they have ...
Clark T, Sawin, David S, Cooper
openaire   +3 more sources

The genetic origin of responses to drugs

British Medical Bulletin, 1995
Individual variation in drug metabolism has been extensively investigated. Population studies have shown that there is a wide range in metabolising ability for all detoxification pathways; the distributions may be unimodal (Gaussian) or polymodal, with subsets of individuals who differ from the majority. These may be poor metabolisers (PM) or extensive
R H, Waring, P, Emery
openaire   +2 more sources

On the origins of drug polypharmacology

MedChemComm, 2013
The ability of many drugs, unintended most often, to interact with multiple proteins is commonly referred to as polypharmacology. Could this be a reminiscent chemical signature of early protein evolution?
Xavier Jalencas, Jordi Mestres
openaire   +1 more source

The origins of antimalarial drug resistance

Trends in Parasitology, 2004
Resistance of Plasmodium falciparum to the antimalarial drug sulfadoxine-pyrimethamine is a result of extremely rare mutations that have spread over large geographical areas. This pattern was completely unexpected because mutations encoding resistance occur commonly in laboratory conditions, leading to the expectation that resistance would originate ...
openaire   +2 more sources

Comparative Study of Drug Efficacy and Drug Additives between Generic Drugs and Original Drugs

Yakugaku Zasshi, 2007
In the present study, we tested three kinds of sleeping drugs, consisting mainly of triazolam, brotizolam, and flunitrazepam, to compare the drug efficacy of generic drugs with that of original drugs. After these drugs were administered orally to mice, drug efficacy was evaluated in terms of ambulation, onset time of sleep, and duration of sleep in the
Hiromi, Katoh, Michiko, Yoshii, Koichiro, Ozawa   +2 more
exaly   +4 more sources