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The Origin of Antithyroid Drugs
Thyroid®, 2023Background: When the antithyroid drugs were discovered in the early 1940s, they were immediately recognized as a revolutionary new treatment for hyperthyroidism. Although much has been learned about their mechanism of action and clinical utility, they continue to be used today in much the same way as they have ...
Clark T, Sawin, David S, Cooper
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The genetic origin of responses to drugs
British Medical Bulletin, 1995Individual variation in drug metabolism has been extensively investigated. Population studies have shown that there is a wide range in metabolising ability for all detoxification pathways; the distributions may be unimodal (Gaussian) or polymodal, with subsets of individuals who differ from the majority. These may be poor metabolisers (PM) or extensive
R H, Waring, P, Emery
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The origins of antimalarial drug resistance
Trends in Parasitology, 2004Resistance of Plasmodium falciparum to the antimalarial drug sulfadoxine-pyrimethamine is a result of extremely rare mutations that have spread over large geographical areas. This pattern was completely unexpected because mutations encoding resistance occur commonly in laboratory conditions, leading to the expectation that resistance would originate ...
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2021
This chapter recounts how human ancestors chewed tree bark and drank herbal tea to relieve their illnesses, whereas today people are more likely to visit the doctor and take prescribed medication. Modern medication generally appears in tablet or capsule form, and the active ingredient will have first appeared in pure form on a chemist's bench.
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This chapter recounts how human ancestors chewed tree bark and drank herbal tea to relieve their illnesses, whereas today people are more likely to visit the doctor and take prescribed medication. Modern medication generally appears in tablet or capsule form, and the active ingredient will have first appeared in pure form on a chemist's bench.
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On the origins of drug polypharmacology
MedChemComm, 2013The ability of many drugs, unintended most often, to interact with multiple proteins is commonly referred to as polypharmacology. Could this be a reminiscent chemical signature of early protein evolution?
Xavier Jalencas, Jordi Mestres
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Comparative Study of Drug Efficacy and Drug Additives between Generic Drugs and Original Drugs
Yakugaku Zasshi, 2007 In the present study, we tested three kinds of sleeping drugs, consisting mainly of triazolam, brotizolam, and flunitrazepam, to compare the drug efficacy of generic drugs with that of original drugs. After these drugs were administered orally to mice, drug efficacy was evaluated in terms of ambulation, onset time of sleep, and duration of sleep in the
Michiko Yoshii
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2012
A brief history of the discovery and invention of a selection of drugs is provided as an introduction to this textbook on clinical trials. Examples were chosen from drugs that are classified as natural products, analogues of naturallyoccurring metabolites, antibodies, and drugs identified by screening libraries of chemicals. Also, as an introduction to
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A brief history of the discovery and invention of a selection of drugs is provided as an introduction to this textbook on clinical trials. Examples were chosen from drugs that are classified as natural products, analogues of naturallyoccurring metabolites, antibodies, and drugs identified by screening libraries of chemicals. Also, as an introduction to
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The Origins of Antimalarial-Drug Resistance
New England Journal of Medicine, 2014There is a tendency to view the development of antimalarial-drug resistance as an inevitable outcome of the drugs' widespread use. Yet resistance has been accelerated by the way the drugs are used and by the social and economic conditions in which they are used.
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