Results 21 to 30 of about 1,504,803 (264)

Baloxavir Marboxil: An Original New Drug against Influenza

open access: yesPharmaceuticals, 2021
Baloxavir marboxil is a new drug developed in Japan by Shionogi to treat seasonal flu infection. This cap-dependent endonuclease inhibitor is a prodrug that releases the biologically active baloxavir acid.
François Dufrasne
doaj   +1 more source

Detection of antimicrobial resistance in Glaesserella parasuis in South China using whole-genome sequencing

open access: yesFrontiers in Microbiology
IntroductionGlaesserella parasuis causes Glässer’s disease in pigs, a leading cause of death in swine herds and a major contributor to economic losses in the global swine industry. Although several studies have investigated antimicrobial resistance in G.
Qianwen Ge   +15 more
doaj   +1 more source

ESTIMATION OF CLINICAL AND PHARMACOKINETIC EQUIVALENCE OF ORIGINAL AND GENERIC CARVEDILOLS IN PATIENTS WITH HYPERTENSION OF 1-2 GRADES

open access: yesРациональная фармакотерапия в кардиологии, 2016
Aim. To study clinical equivalence of original (DilatrendR, ≪Hoffmann-La Roche≫, Switzerland) and of generic (VedicardolR, ≪Synthesis≫, Russia) carvedilols with estimation of their serum level.
E. I. Bambysheva   +5 more
doaj   +1 more source

COMPARATIVE EFFICACY AND SAFETY OF HYPOLIPIDEMIC THERAPY WITH GENERIC AND ORIGINAL MEDICINAL PRODUCTS OF SIMVASTATIN

open access: yesРациональная фармакотерапия в кардиологии, 2016
Aim. To compare efficacy , safety and pharmacoeconomical characteristics of generic and original medicinal products of simvastatin in achievement of cholesterol and low density lipoprotein target levels. Material and methods.
E. I. Tarlovskaya   +3 more
doaj   +1 more source

STUDY OF CLINICAL EFFICACY OF ORIGINAL AND GENERIC DRUGS OF IVABRADINE IN PATIENTS WITH STABLE ANGINA (СOMPARATIVE STUDY)

open access: yesРациональная фармакотерапия в кардиологии, 2018
Aim. To study the therapeutic efficacy and safety of generic drug of ivabradine in comparison with the original drug in patients with stable angina. Material and methods. Patients with stable angina of II-III functional class (n=20) were included into an
S. V. Povetkin, Ju. V. Luneva
doaj   +1 more source

Toward a Cancer Drug of Fungal Origin [PDF]

open access: yesMedicinal Research Reviews, 2015
AbstractAlthough fungi produce highly structurally diverse metabolites, many of which have served as excellent sources of pharmaceuticals, no fungi‐derived agent has been approved as a cancer drug so far. This is despite a tremendous amount of research being aimed at the identification of fungal metabolites with promising anticancer activities.
Kornienko, Alexander   +9 more
openaire   +4 more sources

INTERCHANGEABILITY OF MYOCARDIAL CYTOPROTECTORS IN PATIENTS WITH ISCHEMIC HEART DISEASE. DIFFICULT QUESTIONS –SIMPLE SOLUTIONS

open access: yesРациональная фармакотерапия в кардиологии, 2015
Indications for myocardial cytoprotector, trimetazidine, in patients with ischemic heart disease are analyzed and justified according to evidence based medicine.
Zh. M. Sizova
doaj   +1 more source

Leukemia and Exposure to Potential Benzene Sources in Children From the Mexico City Metropolitan Area, 2010–2021: A Geospatial Analysis

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Leukemia is the most common childhood cancer in Mexico, and acute lymphoblastic leukemia (ALL) is the most frequent subtype. Exposure to high concentrations of benzene has been associated with ALL incidence, particularly in urban areas. This study evaluated the relationship between distance to benzene emission sources and the number
Orlando Rivera Zurita   +5 more
wiley   +1 more source

STATIN GENERICS: EFFICACY AND SAFETY RATIO

open access: yesРациональная фармакотерапия в кардиологии, 2016
Statin usage for primary and secondary prevention of cardiovascular diseases is focused. Rational choice between original and generic drugs is discussed taking into account efficacy and safety ratio.
V. P. Voronina   +4 more
doaj   +1 more source

Association Between Dinutuximab Beta Exposure and Post‐End‐of‐Treatment Survival in Neuroblastoma: A Weighted Patient‐Level Analysis of Three Clinical Studies

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives The association between exposure to dinutuximab beta (DB) and event‐free survival (EFS) or overall survival (OS) of neuroblastoma patients was assessed using data collected during three clinical trials (five cohorts). Methods A systematic review (March 2026) was conducted to identify relevant studies (prospective; registered DB ...
Przemysław Holko   +19 more
wiley   +1 more source

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