Results 61 to 70 of about 6,004,115 (313)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Рациональная фармакотерапия в кардиологии, 2016 Aim. To study the clinical equivalence of original and generic drugs of bisoprolol in patients with arterial hypertension (HT) 1-2 degrees according to protocol recommended by the Society of Cardiology of the Russian Federation for comparative studies ...
S. Yu. Martsevich +6 more
doaj +1 more source
Sudden Death of Cardiac Origin and Psychotropic Drugs [PDF]
Frontiers in Pharmacology, 2012 Mortality rate is high in psychiatric patients versus general population. An important cause of this increased mortality is sudden cardiac death (SCD) as a major side-effect of psychotropic drugs. These SCDs generally result from arrhythmias occurring when the posology is high and may attain a toxic threshold but also at dosages within therapeutic ...
Timour, Quadiri +5 more
openaire +3 more sources
Taking stock: A decade of drug policy - A civil society shadow report. [PDF]
, 2018 Taking stock: A decade of drug policy’ evaluates the impacts of drug policies implemented across the world over the past decade, using data from the United Nations (UN), complemented with peer-reviewed academic research and grey literature reports from ...
core
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Рациональная фармакотерапия в кардиологии, 2019 Aim. Investigation of comparative dissolution kinetics of generic medicinal products containing moxonidine versus reference drug. Material and methods.
G. V. Ramenskaya +3 more
doaj +1 more source
Marine Origin Polysaccharides in Drug Delivery Systems [PDF]
Marine Drugs, 2016 Oceans are a vast source of natural substances. In them, we find various compounds with wide biotechnological and biomedical applicabilities. The exploitation of the sea as a renewable source of biocompounds can have a positive impact on the development of new systems and devices for biomedical applications.
Matias Cardoso, Rui Costa, João Mano
openaire +4 more sources
Preface for buccal drug delivery theme issue [PDF]
, 2014 During the past years, buccal drug delivery has attracted the attention of researchers looking for alternative delivery routes of administration. As an alternative to oral drug delivery, the buccal mucosal route avoids the passage through the acidic ...
Morales, Javier Octavio +3 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Approaches to Drug Pharmacokinetics Study Design in Preclinical Trials (Review)
Регуляторные исследования и экспертиза лекарственных средствINTRODUCTION. According to drug registration requirements, a registration dossier should include the data on preclinical trials of drug pharmacokinetics.
M. V. Karlina +3 more
doaj +1 more source