Results 81 to 90 of about 2,153,835 (285)
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Recalling ancestral SARS-CoV-2 variants: is it an original sin with benefits? [PDF]
Lancet Infect Dis, 2023 Hoehl S, Ciesek S.
europepmc +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Good Housekeeping? Reputation, Fixed Exchange Rates, and the 'Original Sin' Problem [PDF]
This paper examines how the choice of exchange rate regime can signal financial rectitude and, in so doing, influcence a country's ability to borrow internationally in domestic currency.
Kang Yong Tan, Prasanna Gai
core
The Original Risk: Overtheologizing Ethics and Undertheologizing Sin [PDF]
, 2017 The project of articulating a theological ethics on the basis of liturgical anthropology is bound to fail if the necessary consequence is that one has to quit the forum of critical modern rationality.
Müller, Denis
core
Sequence Space Localization in the Immune System Response to Vaccination and Disease
, 2003 We introduce a model of protein evolution to explain limitations in the immune system response to vaccination and disease. The phenomenon of original antigenic sin, wherein vaccination creates memory sequences that can \emph{increase} susceptibility to ...
Deem, Michael W., Lee, Ha Youn
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Teologia urmașilor lui Milian Lauritz Andreasen
TheoRhēma, 2018 The current article has investigated the impact of M. L. Andreasen’s thought with regard to the atonement, the delay of the parousia, the human nature of Christ on a number of influential theological successors of the aforementioned.
Zoltán Szallós-Farkas
doaj +2 more sources
Original Antigenic Sin and Respiratory Syncytial Virus Vaccines
Vaccines, 2019 The original antigenic sin (OAS) theory considers the outcome of the first encounter with an antigen. It favors a memory response to the original antigen upon exposure to a similar or related antigen, and includes both positive and negative impacts of ...
Ralph A. Tripp, Ultan F. Power
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source