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Computational studies of origins of life scenarios [PDF]

open access: yes, 2010
"Understanding the origins of life on Earth is one of the most intriguing problems facing science today. In the research presented here, we apply computational methods to explore origins of life scenarios.
Mathew, Damien C.
core  

Factoring Origin of Life Hypotheses into the Search for Life in the Solar System and Beyond [PDF]

open access: yes, 2020
Two widely-cited alternative hypotheses propose geological localities and biochemical mechanisms for life’s origins. The first states that chemical energy available in submarine hydrothermal vents supported the formation of organic compounds and ...
Alex Longo, Bruce Damer
core   +1 more source

Human prestige psychology can promote adaptive inequality in social influence

open access: yesNature Communications
Human hunter-gatherer groups were commonly thought to be broadly egalitarian, with increasingly formal hierarchical social structures hypothesized to spread following the introduction of agriculture.
Thomas J. H. Morgan   +3 more
doaj   +1 more source

Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways

open access: yesBMC Cancer, 2018
Background Cancer cells require increased levels of nutrients such as amino acids to sustain their rapid growth. In particular, leucine and glutamine have been shown to be important for growth and proliferation of some breast cancers, and therefore ...
Michelle van Geldermalsen   +9 more
doaj   +1 more source

Are Fertility Preservation Procedures Before Gonadotoxic Therapy and Hematopoietic Stem Cell Transplantation Feasible and Safe in Very Young Children? A Retrospective Cohort Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Fertility preservation (FP) is increasingly integrated into the care of pediatric patients exposed to gonadotoxic therapy or conditioning for hematopoietic stem cell transplantation (HSCT), yet perioperative data in infants and toddlers remain scarce.
Kerstin Saalabian   +13 more
wiley   +1 more source

Central Nervous System Neuroblastoma, FOXR2‐Activated: A Pooled Analysis of Published Clinical Outcomes

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) neuroblastoma, FOXR2‐activated, is a recently recognized entity in the WHO CNS5 classification, defined by activation of the FOXR2 transcription factor and unique histopathological features. This review synthesizes available literature and pooled clinical data, providing insight into demographics ...
Sudarshawn Damodharan   +1 more
wiley   +1 more source

Behaviour and the Origin of Organisms [PDF]

open access: yes, 2023
It is common in origins of life research to view the first stages of life as the passive result of particular environmental conditions. This paper considers the alternative possibility: that the antecedents of life were already actively regulating their ...
Hanczyc, Martin M   +17 more
core   +1 more source

THE PROTOBIOLOGICAL THEORY OF CEILINGS AND FLOORS, OR CHEMICAL EVOLUTION AS A PLANETARY PROCESS [PDF]

open access: yesFilozofia i Nauka
The article presents a modern protobiological theory based on the classical archetype. It connects the issues of origins of life with the theory of the hierarchy of matter and recognizes that error correction occurs within hierarchical and dynamic living
Alicja Kubica
doaj   +1 more source

Bioenergetics and Life's Origins [PDF]

open access: yesCold Spring Harbor Perspectives in Biology, 2010
Bioenergetics is central to our understanding of living systems, yet has attracted relatively little attention in origins of life research. This article focuses on energy resources available to drive primitive metabolism and the synthesis of polymers that could be incorporated into molecular systems having properties associated with the living state ...
David, Deamer, Arthur L, Weber
openaire   +2 more sources

Prevalence of 21 Physician‐Defined Severe Toxicities Following Childhood Acute Lymphoblastic Leukemia Treatment: Australian Retrospective Cohort Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with an overall survival now surpassing 90% in developed countries. However, treatments are not without adverse effects. In this study, we apply the severe toxicity‐free survival (STFS) framework to determine the prevalence of 21 physician‐defined severe ...
Lane Collier   +10 more
wiley   +1 more source

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