Results 101 to 110 of about 361,547 (333)
Scientific ReportsSerine proteases are important regulators of airway epithelial homeostasis. Altered serum or cellular levels of two serpins, Scca1 and Spink5, have been described for airway diseases but their function beyond antiproteolytic activity is insufficiently ...
Birte Ehrhardt +9 more
doaj +1 more source
Type 1 diabetes—early life origins and changing epidemiology
The Lancet Diabetes and Endocrinology, 2020 Type 1 diabetes is a chronic, immune-mediated disease characterised by the destruction of insulin-producing cells. Standardised registry data show that type 1 diabetes incidence has increased 3–4% over the past three decades, supporting the role of ...
J. Norris +2 more
semanticscholar +1 more source
Thermodynamics and the origin of life
Canadian Journal of Physics, 2022 Modern developments in nonequilibrium thermodynamics have significant implications for the origins of life. The reasons for this are closely related to a generalized version of the second law of thermodynamics recently found for entropy production during irreversible evolution of a given system such as self-replicating RNA.
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar +7 more
wiley +1 more source
Some Possible Dynamical Constraints for Life`s Origin [PDF]
, 2009 Oscillating biochemical reactions are common in cell dynamics and could be closely related to the emergence of the life phenomenon itself. In this work, we study the dynamical features of some classical chemical or biochemical oscillators where the ...
PENATE, Liuba +4 more
core +1 more source
On the Role of 40K in the Origin of Terrestrial Life
Life, 2022 The abundance and biological role of potassium suggest that its unstable nuclide was present in all stages of terrestrial biogenesis. With its enhanced isotopic ratio in the Archean eon, 40K may have contributed to the special, perhaps unique, biogenetic
Giovanni Vladilo
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction The use of herbal medical preparation (HMP) is rising among pediatric oncology patients, often to manage treatment‐related symptoms. Their effectiveness remains uncertain, and the risk of herb–drug interactions is underestimated.
Orianne Mahot +6 more
wiley +1 more source
Developmental Origins of Chronic Kidney Disease: Should We Focus on Early Life?
International Journal of Molecular Sciences, 2017 Chronic kidney disease (CKD) is becoming a global burden, despite recent advances in management. CKD can begin in early life by so-called “developmental programming” or “developmental origins of health and disease” (DOHaD).
Y. Tain, Chien-Ning Hsu
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric radiation therapy presents unique challenges compared to adult treatments, including those of immobilization, potential need for sedation, and the critical importance of accurate, reproducible positioning. Additionally, heightened attention to imaging doses is necessary to minimize long‐term toxicity in survivors.
Parham Alaei +17 more
wiley +1 more source
The mistery of Life in the ERA of Synthetic Biology [PDF]
, 2022 What is life and how could emerged? These question strictly lies at the core of our understanding the cell both prokaryotic or eukaryotic as smallest living unit.
DEL GAUDIO ROSANNA
core