Results 101 to 110 of about 119,102 (282)
Annals of Neurology, EarlyView.Objective Cerebral ischemic stroke causes neuronal oxygen/energy deprivation, disrupting mitochondrial function including reduced membrane potential and bioenergetics, exacerbating neuronal injury. Mitochondrial defects are, therefore, a central neuropathological node and potential therapeutic target.
Ning Bian +9 more
wiley +1 more source
Perinatal Gene Transfer to the Liver [PDF]
, 2011 The liver acts as a host to many functions hence raising the possibility that any one may be compromised by a single gene defect. Inherited or de novo mutations in these genes may result in relatively mild diseases or be so devastating that death within
Buckley, SM +6 more
core +1 more source
Advanced NanoBiomed Research, EarlyView.Fast‐track to functional human induced pluripotent stem cell (hiPSC)‐derived neurons: This colony‐initiated differentiation approach induces neurogenin 2 overexpression in dense hiPSC colonies (day 0), resulting in a structural reorganization of the colonies (day 2) before they are replated as single cells.
Jann Harberts +9 more
wiley +1 more source
Noninvasive Urinary Monitoring of Progression in IgA Nephropathy. [PDF]
, 2019 Standard methods for detecting and monitoring of IgA nephropathy (IgAN) have conventionally required kidney biopsies or suffer from poor sensitivity and specificity.
Fervenza, Fernando C +4 more
core +1 more source
Channeling of extramitochondrial ornithine to matrix ornithine transcarbamylase.
Journal of Biological Chemistry, 1987 In the presence of citrulline synthesis, we made the following observations. External ornithine is channeled between its transporter and ornithine transcarbamylase; mitochondria preloaded with cold ornithine, then incubated with [3H]ornithine, produced citrulline of the same specific radioactivity as that of external ornithine, while matrix ornithine ...
N S, Cohen, C W, Cheung, L, Raijman
openaire +2 more sources
, 2018 Orotic acid is an intermediate found in the pathway for pyrimidine synthesis. The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) catalyzes the production of orotic acid by the conversion of the compound dihydroorotate to orotic acid.
Fonteh, Aliah L
core +1 more source
Transcriptome pathways unique to dehydration tolerant relatives of modern wheat [PDF]
, 2009 Among abiotic stressors, drought is a major factor responsible for dramatic yield loss in agriculture. In order to reveal differences in global expression profiles of drought tolerant and sensitive wild emmer wheat genotypes, a previously deployed shock ...
AN Olsen +53 more
core +1 more source
Bioprospecting Ulleungdo‐isolated microalgae for carbon valorization and utilization
Biofuels, Bioproducts and Biorefining, EarlyView.Abstract The growing demand for renewable energy alternatives has intensified global interest in microalgae as versatile bioresources for carbon valorization and bioenergy production. Owing to their rapid growth and biochemical versatility, microalgae provide a sustainable route for converting captured carbon into bioenergy and high‐value products ...
Ha‐Neul Choi +5 more
wiley +1 more source
Structural Characterization of Zn(II)-, Co(II)-, and Mn(II)-loaded Forms of the argE-encoded \u3cem\u3eN\u3c/em\u3e-acetyl-L-ornithine Deacetylase from \u3cem\u3eEscherichia coli\u3c/em\u3e [PDF]
, 2012 The Zn, Co, and Mn K-edge extended X-ray absorption fine structure (EXAFS) spectra of the N-acetyl-l-ornithine deacetylase (ArgE) from Escherichia coli, loaded with one or two equivalents of divalent metal ions (i.e., [Zn(II)_(ArgE)], [Zn(II)Zn(II)(ArgE)]
Holz, Richard C. +4 more
core +1 more source