Results 101 to 110 of about 35,585 (229)

Targeting ornithine decarboxylase (ODC) inhibits esophageal squamous cell carcinoma progression

npj Precision Oncology, 2017
Esophageal cancer: African sleeping sickness drug shows activity against tumors Blocking an enzyme involved in the cellular synthesis of essential compounds called polyamines could help treat esophageal cancer.
Wei He, Eunmiri Roh, Ke Yao, Kangdong Liu, Xing Meng, Fangfang Liu, Penglei Wang, Ann M. Bode, Zigang Dong   +8 more
doaj   +1 more source

A role for antizyme inhibitor 2 in the biosynthesis and content of serotonin and histamine in mouse mast cells [PDF]

, 2015
Polyamines (putrescine, spermidine and spermine; PAs) are essential for the majority of living cells. Antizymes and antizyme inhibitors are key regulatory proteins of PA levels by affecting ornithine decarboxylase and PA uptake.
Acosta-Andrade, Carlos, Fajardo-Paredes, Ignacio José, Lambertos, Ana, Peñafiel, Rafael, Sanchez-Jimenez, Francisca Maria, Urdiales-Ruiz, Jose Luis   +5 more
core  

Structural and degradative aspects of ornithine decarboxylase antizyme inhibitor 2

FEBS Open Bio, 2014
Ornithine decarboxylase (ODC) is the key enzyme in the polyamine biosynthetic pathway. ODC levels are controlled by polyamines through the induction of antizymes (AZs), small proteins that inhibit ODC and target it to proteasomal degradation without ...
Bruno Ramos-Molina, Ana Lambertos, Andrés J. Lopez-Contreras, Joanna M. Kasprzak, Anna Czerwoniec, Janusz M. Bujnicki, Asunción Cremades, Rafael Peñafiel   +7 more
doaj   +1 more source

A role for antizyme inhibitor 2 in the biosynthesis and content of histamine and serotonin in mouse mast cells [PDF]

, 2015
Polyamines (putrescine, spermidine and spermine; PAs) are required for the survival of the majority of living cells. Antizymes and antizyme inhibitors are key regulatory proteins of PA levels by affecting ornithine decarboxylase, the rate-limiting ...
Acosta-Andrade, Carlos, Fajardo-Paredes, Ignacio José, Lambertos, Ana, Peñafiel, Rafael, Sanchez-Jimenez, Francisca Maria, Urdiales-Ruiz, Jose Luis   +5 more
core  

Induction of hyperammonia in irradiated hepatoma cells: a recapitulation and possible explanation of the phenomenon [PDF]

, 2004
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J van Rijn, J van den Berg, R G Schipper, S de Jong, V Cuijpers, A A J Verhofstad, T Teerlink, C Cabella, E Grassilli, K Miyazaki, RG Schipper, N Seiler, J Van Rijn   +12 more
core   +1 more source

Characterization of OAZ1 and its potential functions in goose follicular development

Electronic Journal of Biotechnology, 2017
Background: Ornithine decarboxylase antizyme 1 (OAZ1) is an important regulator of polyamine synthesis and uptake. Our previous studies indicated that high OAZ1 expression in the ovaries of laying geese is responsible for poor egg production.
Bo Kang, Dongmei Jiang, Hui He, Rong Ma, Zhixin Yi, Ziyu Chen   +5 more
doaj   +1 more source

Investigation on Ornithine Decarboxylase Activity and Level of Putrescine, Spermidine and Spermine in Hydatid Cyst

Journal of Ardabil University of Medical Sciences, 2017
Background & objectives: Polyamines such as putrescine, spermidine, and spermine are ubiquitous in all eukaryotic cells and play an essential role in cell division and differentiation. One way of polyamine biosynthesis is done by ornithine decarboxylase (
Somayeh Bahrami, Hossein Najafzadeh, Ali Shahriari, Sara Ahmadi, Mohammadhossein Razi Jalali   +4 more
doaj  

Optimized LC-MS method for simultaneous polyamine profiling and ADC/ODC activity quantification and evidence that ADCs are indispensable for flower development in tomato

Frontiers in Plant Science
IntroductionPolyamines (PAs) are essential for plant development and stress responses, requiring tight homeostatic regulation. As many PA enzymes are regulated post-transcriptionally, transcript-based methods cannot accurately predict protein abundance ...
Erin Samantha Ritchie, Edda von Roepenack-Lahaye, Dennis Perrett, Dousheng Wu, Thomas Lahaye   +4 more
doaj   +1 more source

Inhibition of ornithine decarboxylase facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models [PDF]

, 2017
INTRODUCTION: Arginine depletion has shown anticancer effects among arginine auxotrophic cancers. Pegylated arginase (BCT-100) depletes arginine by converting arginine to ornithine.
Ho, JCM, Lam, SK, Xu, S
core  

Heterologous expression and activity verification of ornithine decarboxylase from a wild strain of Shewanella xiamenensis. [PDF]

Front Microbiol, 2022
Liu C, Wang G, Han X, Cao L, Wang K, Lin H, Sui J.   +6 more
europepmc   +1 more source