Results 161 to 170 of about 6,839 (201)

Role of ornithine decarboxylase antizyme inhibitor in vivo

Genes to Cells, 2008
Ornithine decarboxylase (ODC) antizyme inhibitor (AZI) has been shown to regulate ODC activity in cell cultures. However, its biological functions in an organism remain unknown. An embryonic stem (ES) cell clone was established, in which the Azin1 gene was disrupted by the gene trap technique.
Hua, Tang, Kimi, Ariki, Makiko, Ohkido, Yasuko, Murakami, Senya, Matsufuji, Zhenghua, Li, Ken-ichi, Yamamura   +6 more
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Ornithine decarboxylase inhibitors and fetal growth retardation in mice

Teratology, 1983
AbstractPutrescine (PUT) and the putrescine analogues, 1,3‐diaminopropane (DAP) and 1,6‐diaminohexane (DAH), were administered to pregnant female mice during the time of maximal fetal ornithine decarboxylase (ODC) activity, days 10–14 of gestation.
C A, Manen, R D, Hood, J, Farina
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Kinetics of α-difluoromethylornithine: An irreversible inhibitor of ornithine decarboxylase

Clinical Pharmacology and Therapeutics, 1981
We gave alpha-difluoromethylornithine (DFMO), a selective, irreversible inhibitor of ornithine decarboxylase, to six health men in single intravenous doses of 5 and 10 mg/kg body weight and oral doses of 10 and 20 mg/kg. Plasma concentrations were monitored during the 24 hr after each dose.
K D, Haegele, R G, Alken, J, Grove, P J, Schechter, J, Koch-Weser   +4 more
openaire   +2 more sources

Allicin, a Potent New Ornithine Decarboxylase Inhibitor in Neuroblastoma Cells

Journal of Natural Products, 2020
The natural product allicin is a reactive sulfur species (RSS) from garlic (Allium sativum L.). Neuroblastoma (NB) is an early childhood cancer arising from the developing peripheral nervous system. Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the biosynthesis of polyamines, which are oncometabolites that contribute to cell proliferation ...
Chad R. Schultz, Martin C. H. Gruhlke, Alan J. Slusarenko, André S. Bachmann   +3 more
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Regulations of thyroid decarboxylase by the polyamines Induction of a protein inhibitor of ornithine decarboxylase by the end-products of the reaction

Biochimica et Biophysica Acta (BBA) - General Subjects, 1977
When spermidine, putrescine or 1,3-diaminopropane was injected (12.5 mumol/100 g body weight) into rats 1 h before thyrotropin, ornithine decarboxylase activity was increased by 75--150% over control levels. However, when greater than or equal to 75 mumol polyamine/100 g body weight was injected, thyrotropin-activated activity was inhibited by 70--95%.
Y, Friedman, S, Park, S, Levasseur, G, Burke   +3 more
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Histochemical localization of ornithine decarboxylase with a labelled suicidal enzyme inhibitor

Biochemical and Biophysical Research Communications, 1980
Abstract We describe a new technique for cytochemical localization of ornithine decarboxylase by the use of a synthesized conjugate of rhodamine bound to α-difluoromethylornithine a suicidal inhibitor of the enzyme. The labelled inhibitor retained its specificity and irreversibility towards ornithine decarboxylase inhibition.
G M, Gilad, V H, Gilad
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Fluorescent Location of Ornithine Decarboxylase Employing Derivatives of the Specific Inhibitor α-Difluoromethyl Ornithine

Journal of Enzyme Inhibition, 1989
Two fluorescent derivatives have been made from alpha-difluoromethyl ornithine by linking the carboxyl group of the ornithine derivatives to fluorescent amines. alpha-difluoromethyl ornithine is a potent inhibitor of ornithine decarboxylase, an enzyme which plays an essential role in cell division.
F S, Steven, L A, Williams, P, Warne, D F, Tucker   +3 more
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Subcellular distribution of ornithine decarboxylase in rat liver and accessibility of the enzyme to α-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase

Life Sciences, 1983
The subcellular localisation of ornithine decarboxylase and of its synthetic irreversible inhibitor, alpha-difluoromethylornithine, was investigated in control rat livers and in livers of animals in which the enzyme was induced by partial hepatectomy or by treatment with dexamethasone.
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[Aminooxypropylamine--an effective inhibitor of ornithine decarboxylase in vitro and in vivo].

Bioorganicheskaia khimiia, 1986
Hydroxylamine-containing analogues of putrescine and cadaverine have been found effective in inhibiting the mouse liver ornithine decarboxylase, the best among synthesized were 1-aminooxy-3-aminopropane (I50 2.10(-8) M) and 1-aminooxy-4-aminobutane (I50 2.10(-7) M). The inhibitory effect of these substances on the mouse liver ornithine-transaminase and
R M, Khomutov, G F, Denisova, A R, Khomutov, K M, Belostotskaia, R B, Shlosman   +4 more
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ChemInform Abstract: INHIBITORS OF POLYAMINE BIOSYNTHESIS PART 1, ALPHA‐METHYL‐(+‐)‐ORNITHINE, AN INHIBITOR OF ORNITHINE DECARBOXYLASE

Chemischer Informationsdienst, 1974
Abstract5‐Chlor‐2‐pentanon (I) reagiert mit Phthalimidkalium (II) zum Imid (III), aus dem das Hydantoin (IV) erhalten wird.′Die Hydrolyse liefert die geschützten Methylomithin‐Derivate (V) und (VI), die zum Ornithin (VII) verseift werden.
M. M. ABDEL‐MONEM, N. E. NEWTON, C. E. WEEKS   +2 more
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