Results 151 to 160 of about 6,839 (201)

Involvement of polyamine catabolism in theregulation of glucose, energy and cholesterol metabolism in mice [PDF]

Pirinen, Eija
core  

Immunometabolism in lung cancer - The link between metabolism and immune response. [PDF]

iScience
Eivazzadeh Y, Orooji N, Eskandari T, Tarahomi M, Tavassoli Razavi F, Haghmorad D.   +5 more
europepmc   +1 more source

The Physiological Roles and Pathological Implications of Urea Transporters in the Cardiovascular System. [PDF]

Biomedicines
Shao G, Qiu Z, Li M, Yang B, Yu X, Ji F.
europepmc   +1 more source

Polyamines regulate mitochondrial metabolism essential for intestinal epithelial renewal and wound healing. [PDF]

Am J Physiol Gastrointest Liver Physiol
Cairns CA, Chen T, Han N, Chen H, Chung HK, Xiao L, Wang JY.   +6 more
europepmc   +1 more source

Evolution, composition and functions of cullin E3 ubiquitin ligases in trypanosomes. [PDF]

Sci Rep
Del Pino RC, Zoltner M, Butterfield ER, Field MC.   +3 more
europepmc   +1 more source

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The rational discovery of multipurpose inhibitors of the ornithine decarboxylase

FASEB Journal, 2020
Abstract Metabolic reprograming is a hallmark of cancer, and the polyamine metabolic network is dysregulated in many cancers. Ornithine decarboxylase (ODC) is a rate‐limiting enzyme for polyamine synthesis in the polyamine metabolic network. In many cancer cells, ODC is over‐expressed, so this enzyme has been an attracting anti‐cancer
Sen Liu
exaly   +3 more sources

Plasmodium berghei: Inhibitors of ornithine decarboxylase block exoerythrocytic schizogony

Experimental Parasitology, 1985
DL-alpha-difluoromethylornithine and DL-alpha-monofluoromethyldehydroornithine methyl ester, inhibitors of ornithine decarboxylase, blocked exoerythrocytic schizogony of Plasmodium berghei in mice and in cultured human hepatoma cells. These effects were reversed by exogenous administration of the polyamine, spermidine. The antimalarial drug, primaquine,
Michael R Hollingdale, P P Mccann, Albert Sjoerdsma   +2 more
exaly   +3 more sources

Effect of ornithine decarboxylase inhibitors on the germination of sporangiospores of mucorales

Experimental Mycology, 1987
Abstract Of several known inhibitors of ornithine decarboxylase activity, only 1,4-diamino-2-butanone (DAB) inhibited spore germination of Mucor rouxii. Drug-exposed cells went through the phase of spherical growth attaining huge cell volumes, but were unable to germinate.
JOSÉ Ruiz-Herrera, CARLOS Calvo-Mendez   +1 more
exaly   +2 more sources

Ornithine and arginine decarboxylase activities and effect of some polyamine biosynthesis inhibitors on Gigaspora rosea germinating spores [PDF]

FEMS Microbiology Letters, 2004
The pathways for putrescine biosynthesis and the effects of polyamine biosynthesis inhibitors on the germination and hyphal development of Gigaspora rosea spores were investigated.
Analía Inés Sannazzaro, Fernando L Pieckenstain, OSCAR A Ruiz   +2 more
exaly   +2 more sources

Computational and experimental evaluation of ornithine derivatives as ornithine decarboxylase inhibitors

Medicinal Chemistry Research, 2008
Polyamines play a relevant role in living cells because they are involved in several biological processes such as cell proliferation, transcription, and translation. In this article, we report the synthesis and in vitro evaluation of an ornithine analogue (6) as an ornithine decarboxylase (ODC) inhibitor.
J. Correa-Basurto, L. Rodríguez-Páez, E. S. Aguiar-Moreno, P. López-Sánchez, L. M. Espinoza-Fonseca, C. Wong, J. Trujillo-Ferrara   +6 more
openaire   +1 more source