Results 81 to 90 of about 2,711,207 (206)

Cycloheximide sensitivity of orotic acid biosynthesis induced by ammonia and glycine administration

, 1998
Administration of either ammonia or glycine to both rats and mice results in an increased synthesis in the liver and urinary excretion of orotic acid.
Lofrumento N.E., Laconi E, Sarma DS, Fransvea E, Rajalakshmi S, LA PIANA, Gianluigi, Rao PM, Marzulli D, Vasudevan S   +8 more
core  

Sea Cucumber Saponins Derivatives Alleviate Hepatic Lipid Accumulation Effectively in Fatty Acids-Induced HepG2 Cells and Orotic Acid-Induced Rats. [PDF]

Mar Drugs, 2022
Li X, Zeng B, Wen L, Zhao Y, Li Z, Xue C, Zhang T, Wang Y.   +7 more
europepmc   +1 more source

Effects of salicylate on the incorporation of orotic acid into nucleic acids of mouse tissues in vivo

, 1970
In mice, given intraperitoneal injections of orotic acid-5-3H, two peaks of incorporation of radioactivity at 30 min and 6 h occurred in the RNA of kidney and of liver and its subcellular components.
K Janakidevi, M J H Smith
core   +1 more source

Persistent Hyperammonemia in Two Related Morgan Weanlings

Journal of Veterinary Internal Medicine, 1997
Persistent hyperammonemia was diagnosed in 2 Morgan fillies with clinical signs that developed early in the post‐weaning period. Diagnostic evaluation, including routine serum chemistries, CBC, liver biopsy, hepatic ultrasonography, liver function test ...
Rebecca S. McConnico, Wendy M. Duckett, Philip A. Wood   +2 more
doaj   +1 more source

Research Progress on Mechanism of Action of DHODH in Progression of Malignant Tumors

Zhongliu Fangzhi Yanjiu
Dihydroorotate dehydrogenase (DHODH) is a flavin-dependent metabolic enzyme that oxidizes dihydroorotate acid to orotic acid in the de novo synthesis pathway of pyrimidine metabolism.
CHE Xin, HU Zhen, WANG Yonggang, LI Yaoping   +3 more
doaj   +1 more source

Insight into the role of bound water of a nucleating agent in polymer nucleation: a comparative study of anhydrous and monohydrated orotic acid on crystallization of poly(l-lactic acid)

, 2017
The bound water of orotic acid and its dehydration transition play a negative role in nucleation effects on PLLA crystallization.
Lin Sang, Liuchun Zheng, Chao Wang, Zhiyong Wei, Ping Song, Kankan Liu   +5 more
core   +1 more source

Differential Sensitivity to 5-fluoro-orotic Acid as a Screen for Bait RNA Independent False Positives in a Yeast Three-Hybrid System

BioTechniques, 1999
The yeast three-hybrid system presents a valuable tool for detecting and analyzing RNA-protein interactions in vivo. A major drawback of the use of such a transcriptional reporter-based assay in a library screen is the frequent occurrence of false ...
Young Woo Park, Seng-Lai Tan, Michael G. Katze   +2 more
doaj   +1 more source

Dietary Food Fortified with Orotic Acid and Liver Function

, 2012
The effects of dietary food fortified with orotic acid (1.0%) on liver function were studied in rats. The rats fed with orotic acid promoted liver triglyceride content markedly, that was 5-fold higher than that of the control.
Yohanes Buang; Department of Chemistry, Faculty of Science and Engineering, Nusa Cendana University, Kupang 85001
core  

Importance of ornithine transcarbamylase (OTC) deficiency in small intestine for urinary orotic acid excretion: Analysis of OTC-deficient spf-ash mice with OTC transgene

, 1995
We report the effect of the ornithine transcarbamylase (OTC) transgene composed of 1.3 kb of the 5' flanking region of the rat OTC gene fused to rat OTC cDNA on urinary orotic acid excretion in OTC-deficient spf-ash (sparse-fur with abnormal skin and ...
Obara, Touru, Saheki, Takeyori, Horiuchi, Megumi, Kobayashi, Keiko, Yamamura, Ken-ichi, Mori, Kouji, Shige, Toyoko, Suzuki, Syusaku, Mori, Masataka   +8 more
core   +1 more source

Use orotic acid in the treatment of pathological conditions associated with hyperuricemia

, 2014
Hyperuricemia - a condition characterized by elevated relative to normal ranges, levels of uric acid in the blood. Among the diseases caused by hyperuricemia, most noteworthy are gout, urate nephropathy, and urolithiasis.
D.D. Ivanov, Ya.A. Dombrovskyi
core   +1 more source