Results 41 to 50 of about 4,091 (157)

Identification of MscS as a Key L‐Glutamate Exporter in Bacillus methanolicus

Microbial Biotechnology, Volume 18, Issue 10, October 2025.
l‐Glutamate export in the methylotrophic bacterium Bacillus methanolicus, driven by an MscS‐like mechanosensitive channel. Figure created with BioRender (https://BioRender.com/t99s28). ABSTRACT Small‐conductance mechanosensitive channels (MscS) are established l‐glutamate exporters in industrially relevant bacteria, yet their role in the methylotrophic
Luciana Fernandes Brito, Davide Luciano, Marta Irla, David Virant, Gaston Courtade, Trygve Brautaset   +5 more
wiley   +1 more source

Deletion of the Zinc Transporter Lipoprotein AdcAII Causes Hyperencapsulation of Streptococcus pneumoniae Associated with Distinct Alleles of the Type I Restriction-Modification System. [PDF]

, 2020
The capsule is the dominant Streptococcus pneumoniae virulence factor, yet how variation in capsule thickness is regulated is poorly understood. Here, we describe an unexpected relationship between mutation of adcAII, which encodes a zinc uptake ...
Arioli, Bayle, Bentley, Brown, Brown, Brown, Brown, Dintilhac, Domenech, Domenech de Cellès, Donini, Eijkelkamp, Faille, Geno, Giammarinaro, Giefing-Kröll, Gillespie, Hammerschmidt, Hathaway, Henrichsen, Hyams, Hyams, James, Johnston, Junges, Kietzman, Kim, Kim, Kohler, Li, Loisel, Loisel, Manso, Morona, Nelson, Oggioni, Oliver, Plumptre, Rowland, Sanchez, Sanchez, Schaffner, Trappetti, Ulijasz, Ventura, Weiser, Wilson, Wilson, Wu, Yadav, Yahiaoui, Yother   +51 more
core   +4 more sources

Improvement of β‐Xylosidase and Endoxylanase Activities in Talaromyces amestolkiae by Genetic Manipulation of the Transcriptional Activator XlnR

Microbial Biotechnology, Volume 18, Issue 5, May 2025.
A successful transformation procedure for the genetic manipulation of the fungus Talaromyces amestolkiae was developed, enabling the forced expression of the transcriptional activator XlnR. A mutant version of XlnR carrying a Val785Phe substitution led to remarkably higher β‐xylosidase and endoxylanase activities compared to the wild‐type strain, which
Ana Pozo‐Rodríguez, Miguel Ángel Peñalva, Jorge Barriuso, Eduardo A. Espeso, María Jesús Martínez   +4 more
wiley   +1 more source

Cre-loxP-based system for removal and reuse of selection markers in Ashbya gossypii targeted engineering [PDF]

, 2014
The filamentous ascomycete Ashbya gossypii is amenable to genetic manipulation and is an excellent model system for studying eukaryotic cell biology.
Aguiar, Tatiana Quinta, Dinis, Cláudia, Domingues, Lucília   +2 more
core   +1 more source

Metabolism and signaling crosstalk in glioblastoma progression and therapy resistance

Molecular Oncology, Volume 19, Issue 3, Page 592-613, March 2025.
Glioblastoma is one of the most lethal human cancers with no effective treatment nowadays. Here, we review the increasing amount of evidence supporting the connection between cell signaling deregulation and metabolic reprogramming as a key event in glioblastoma resistance to cancer therapy.
Laura Zarzuela, Raúl V. Durán, Mercedes Tomé   +2 more
wiley   +1 more source

How a fungus shapes biotechnology: 100 years of Aspergillus niger research [PDF]

, 2018
In 1917, a food chemist named James Currie made a promising discovery: any strain of the filamentous mould Aspergillus niger would produce high concentrations of citric acid when grown in sugar medium.
Cairns, Timothy C., Meyer, Vera, Nai, Corrado   +2 more
core   +2 more sources

The cis‐prenyltransferase protein family in Taraxacum koksaghyz

The Plant Journal, Volume 121, Issue 3, February 2025.
Significance Statement The novelty of this work lies in the comprehensive description of cis‐prenyl transferases in the rubber‐producing plant Taraxacum koksaghyz. This provides valuable insights for breeding and rational protein design in heterologous systems.
Boje Müller, Eva Niephaus, Wolfgang Eisenreich, Jan Niklas Bröker, Richard M. Twyman, Dirk Prüfer, Christian Schulze Gronover   +6 more
wiley   +1 more source

The \u3cem\u3eMeiothermus ruber\u3c/em\u3e Mrub_2572 gene is an ortholog of the \u3cem\u3eEscherichia coli\u3c/em\u3e pyrE b3642 gene and the \u3cem\u3eMeiothermus ruber\u3c/em\u3e Mrub_2071 gene is an ortholog of the \u3cem\u3eEscherichia coli\u3c/em\u3e pyrF b1281 gene [PDF]

, 2016
This project is part of the Meiothermus ruber genome analysis project, which uses the bioinformatics tools associated with the Guiding Education through Novel Investigation –Annotation Collaboration Toolkit (GENI-ACT) to predict gene function.
McCormick, Cale J, Scott, Dr. Lori
core   +1 more source

A novel plasmid‐based experimental system in Saccharomyces cerevisiae that enables the introduction of 10 different plasmids into cells

FEBS Open Bio, Volume 14, Issue 12, Page 1955-1971, December 2024.
We developed the Saccharomyces cerevisiae strains termed Δ10 that exhibit auxotrophic behavior for 10 different nutrients and the plasmids with auxotrophic markers for use in Δ10 strains. Δ10 strains were able to maintain 10 types of plasmids by auxotrophic selection.
Geyao Dong, Tsuyoshi Nakai, Tetsuo Matsuzaki   +2 more
wiley   +1 more source

Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space? [PDF]

, 2006
The organization and mining of malaria genomic and post-genomic data is highly motivated by the necessity to predict and characterize new biological targets and new drugs. Biological targets are sought in a biological space designed from the genomic data
Bastien, Olivier, Birkholtz, Lyn-Marie, Breton, Vincent, Grando, Delphine, Hofmann-Apitius, Martin, Jacq, Nicolas, Joubert, Fourie, Kasam, Vinod, Louw, Abraham I, Maréchal, Eric, Ortet, Philippe, Roy, Sylvaine, Saïdani, Nadia, Wells, Gordon, Zimmermann, Marc   +14 more
core   +5 more sources