Results 141 to 150 of about 160,917 (252)

Unlocking access: a comprehensive analysis of medicines accessibility for rare diseases in Thailand. [PDF]

Orphanet J Rare Dis
Suwattanapreeda S, Hirunrassamee S, Sooksriwong C, Maluangnon K, Chuachantra T, Kuchaisit K, Osirisakul N.   +6 more
europepmc   +1 more source

The Role of Interleukin‐23 and Interleukin‐17 in Peri‐Implant Crevicular Fluid of Subjects With Peri‐Implant Disease: A Systematic Review

Journal of Clinical Laboratory Analysis, Volume 39, Issue 15, August 2025.
The role of IL‐23/IL‐17 cytokine axis in peri‐implant disease. ABSTRACT Background Activation of the IL‐23/IL‐17 cytokine axis could trigger peri‐implant bone loss. The aim of this review was to analyze whether in people with peri‐implantitis (PI) and peri‐implant mucositis (PM) the concentrations of the interleukin‐23 and interleukin‐17 in peri ...
Mario Alberto Alarcón‐Sánchez, Julieta Sarai Becerra‐Ruiz, Ruth Rodríguez‐Montaño, Sarah Monserrat Lomelí‐Martínez, Lilibeth‐Stephania Escoto‐Vasquez, Artak Heboyan   +5 more
wiley   +1 more source

The rare disease burden: a multidimensional challenge. [PDF]

Acta Biochim Pol
Cyske Z, Radzanowska-Alenowicz E, Rintz E, Gaffke L, Pierzynowska K.   +4 more
europepmc   +1 more source

Multicenter Single‐Blind Randomized Controlled Trial of the Romiplostim Biosimilar

eJHaem, Volume 6, Issue 4, August 2025.
Abstract Background This was a randomized multicenter single‐blinded active‐controlled equivalence Phase III study evaluating the efficacy and safety of the biosimilar of romiplostim (GP40141) compared to the reference drug Nplate in patients with persistent or chronic immune thrombocytopenia (ITP).
Anait L. Melikyan, Ekaterina A. Protsenko, Galina N. Salogub, Bulat A. Bakirov, Igor L. Davydkin, Vladislav V. Kovalik, Mariia L. Gefen, Yuliia D. Matvienko, Valeria B. Saparova, Alexander L. Khokhlov, Igor E. Makarenko, Roman V. Drai   +11 more
wiley   +1 more source

Debates over orphan drug pricing: a meta-narrative literature review. [PDF]

Orphanet J Rare Dis
Hanchard MS.
europepmc   +1 more source

Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase–Dependent Regulation of the Orphan Nuclear Receptor SHP

Diabetes, 2008
Y. D. Kim, K. Park, Yong-soo Lee, Yun‐Yong Park, Don-Kyu Kim, Balachandar Nedumaran, W. Jang, W. Cho, J. Ha, In-kyu Lee, Chul-Ho Lee, Hueng-Sik Choi   +11 more
semanticscholar   +1 more source

Mangiferin Against Respiratory Diseases: Pharmacological Targets and Prospects

Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
ABSTRACT Respiratory diseases are associated with high mortality worldwide. Respiratory infections can lead to the emergence of chronic respiratory diseases. Scientists are constantly striving to identify new therapies with reduced side effects.
Kazi Ahsan Ahmed, Nusrat Afrin, Popy Ghosh, Irin Amin Heya, Sajidur Rahman Akash, Akhi Moni, Mohammad Nazrul Islam, Md. Golzar Hossain, Alessandra Sinopoli, Md Abdul Hannan, Md Jamal Uddin   +10 more
wiley   +1 more source

Improving the Reimbursement Process for New Drugs: A Case Study of a Two-Waiver System in South Korea. [PDF]

J Eval Clin Pract
Yu SR.
europepmc   +1 more source

Evaluation and Valuation of the Price of Expensive Medicinal Products: Application of the Discounted Cash Flow to Orphan Drugs

International Journal of Rare Diseases & Disorders, 2018
Fugel Hans Joerg, Vis Jan, Nuijten Mark
openaire   +1 more source

Efficacy of IDOR‐1117‐2520, a novel, orally available CCR6 antagonist in preclinical models of skin dermatitis

British Journal of Pharmacology, Volume 182, Issue 15, Page 3452-3475, August 2025.
Background and Purpose The chemokine receptor CCR6 guides pathogenic T17 cells, implicated in autoimmune diseases including psoriasis, to sites of inflammation via the chemokine CCL20. Therefor, pharmacological inhibition of CCR6+ immune cell migration provides a novel therapeutic approach.
Paulina Kulig, Pijus Brazauskas, Madeleine Suffiotti, Emilie Raoult, Ulrike Babilonski, Bérengère Renault, Ursula Grieder, Enrico Vezzali, Peter Blattmann, Marianne M. Martinic, Mark J. Murphy   +10 more
wiley   +1 more source