Results 151 to 160 of about 160,917 (252)

Clinical data required for the approval of pediatric pharmaceuticals in Japan. [PDF]

BMC Pediatr
Haigo H, Matsuda K, Shikano M.
europepmc   +1 more source

Dimerisation of the VIP receptor VIPR2 is essential to its binding VIP and Gαi proteins, and to its functions in breast cancer cells

British Journal of Pharmacology, Volume 182, Issue 15, Page 3612-3627, August 2025.
Abstract Background and Purpose Several G protein‐coupled receptors (GPCRs) are known to homodimerise. Dimeric GPCRs may have different properties from their monomers, but the molecular basis and functional significance of GPCR dimerisation remain largely unknown.
Satoshi Asano, Kairi Ozasa, Teru Uehara, Rei Yokoyama, Takanobu Nakazawa, Souichi Yanamoto, Yukio Ago   +6 more
wiley   +1 more source

Rare disease challenges and potential actions in the Middle East. [PDF]

Int J Equity Health
Fasseeh AN, Korra N, Aljedai A, Seyam A, Almudaiheem H, Al-Abdulkarim HA, Janahi M, Gamal M, Fahmy S, Aldallal S, Abaza S, Kaló Z.   +11 more
europepmc   +1 more source

Artemisinins in autoimmune diseases: effects and mechanisms in systemic lupus erythematosus and rheumatoid arthritis

British Journal of Pharmacology, Volume 182, Issue 15, Page 3411-3427, August 2025.
Abstract Autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) result from immune self‐tolerance loss, causing tissue damage. Standard treatments targeting late‐stage inflammation often have serious side effects. Artemisinin, known for its antimalarial properties, shows potential immunomodulatory effects.
Fanchao Zhou, Guoming Li, Ruixiang Tan, Guodong Wu, Changsheng Deng   +4 more
wiley   +1 more source

Hereditary Angioedema (HAE) in China: Advancing Awareness, Access, Advocacy and Alliances From the Greater Bay Area to the Global HAE Community

Clinical &Experimental Allergy, Volume 55, Issue 8, Page 659-670, August 2025.
Through the ‘4As’: Awareness, Access, Advocacy, and Alliance, the Greater Bay Area will continue to leverage its unique advantages to confront ongoing challenges such as diagnostic delays and lack of access to diagnosis and hereditary angioedema (HAE)‐specific medications.
Philip H. Li, Jin‐Xian Huang, Can‐Tian Wang, Jane C. Y. Wong, Hao Chen, Bao Chai, Liang Chen, He Lai, Shuo Li, Yan‐Hua Liang, Yun‐Sheng Liang, Ning Liu, Bing Lu, Bao‐Qing Sun, Qin‐Tai Yang, Fei Ye, Jiang‐Lin Zhang, Shu‐Chen Zhang, Zuo‐Tao Zhao, Min Zhou, Xian‐Biao Zou, Guang‐Hui Liu, Kai Guan   +22 more
wiley   +1 more source

DeepES: deep learning-based enzyme screening to identify orphan enzyme genes. [PDF]

Bioinformatics
Hirota K, Salim F, Yamada T.
europepmc   +1 more source

Vitiligo

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 23, Issue 8, Page 968-987, August 2025.
Summary Vitiligo is a common pigment disorder of the skin resulting in destruction of melanocytes. Non‐segmental vitiligo (NSV) is an autoimmune disorder. The etiopathogenesis of segmental vitiligo (SV) remains incompletely understood. Genetic predisposition and increased vulnerability of melanocytes towards stressors lead to a melanocyte‐specific CD8+
Markus Böhm, Adrian Tanew
wiley   +1 more source

Pediatric-onset rare disease therapy pipeline yields hope for some and gaps for many: 10-year projection of approvals, treated patients, and list price revenues. [PDF]

J Manag Care Spec Pharm
Young CM, Phares SE, Kennedy A, Sullivan J, McGowan B, Trusheim MR.   +5 more
europepmc   +1 more source

Metformin ameliorates IL-6-induced hepatic insulin resistance via induction of orphan nuclear receptor small heterodimer partner (SHP) in mouse models

Diabetologia, 2012
Yong Deuk Kim, Yong Hoon Kim, Youn-Jin Cho, Dae-Sun Kim, Sung-Youll Ahn, Jong-Hong Lee, Dipanjan Chanda, M. Shong, Chul-Ho Lee, Hyo-Pum Choi   +9 more
semanticscholar   +1 more source

Anchored Indirect Treatment Comparison Finds Comparable Effects of Pegcetacoplan and Iptacopan in Paroxysmal Nocturnal Haemoglobinuria

European Journal of Haematology, Volume 115, Issue 2, Page 125-133, August 2025.
ABSTRACT Background Paroxysmal nocturnal haemoglobinuria (PNH) is an ultra‐rare, acquired non‐malignant haematological disorder characterised by thrombosis risk, serious complications and debilitating symptoms in untreated patients. Objective This anchored indirect treatment comparison (ITC) evaluated efficacy data between proximal complement 3 ...
Regis Peffault de Latour, Austin Kulasekararaj, David Dingli, Koo Wilson, Piotr Wojciechowski, Zalmai Hakimi, Jameel Nazir, Barbara Czech, Peter Hillmen, Jeff Szer   +9 more
wiley   +1 more source