A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders
Clinical Pharmacology &Therapeutics, EarlyView.Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel +3 more
wiley +1 more source
Exposure to polybrominated diphenyl ethers (PBDEs) suppresses the release of pro-inflammatory products by alveolar macrophages in vitro [PDF]
, 2010 Endocrine disrupting chemicals have adverse effects on immune function that may result in respiratory conditions. Inhalation of dust is a major route of exposure to PBDEs; however, the impact of PBDEs on the immune response is unclear.
Hennigar, Stephen R
core +1 more source
Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway. [PDF]
, 2008 The liver is responsible for key metabolic functions, including control of normal homoeostasis in response to diet and xenobiotic metabolism/detoxification.
Finn, Robert +3 more
core +2 more sources
Nurr1 dependent regulation of pro-inflammatory mediators in immortalised synovial fibroblasts
Journal of Inflammation, 2005 Background Nurr1 is an orphan member of the nuclear receptor superfamily; these orphan receptors are a group for which a ligand has yet to be identified.
Parker Andrew E +6 more
doaj +1 more source
Central mechanisms mediating the hypophagic effects of oleoylethanolamide and N-acylphosphatidylethanolamines: different lipid signals? [PDF]
, 2015 The spread of "obesity epidemic" and the poor efficacy of many anti-obesity therapies in the long-term highlight the need to develop novel efficacious therapy. This necessity stimulates a large research effort to find novel mechanisms controlling feeding
Gaetani, Silvana +4 more
core +2 more sources
Advances in GPCRs Associated With Wnt Signaling Within the Auditory System
Medicine Bulletin, EarlyView.ABSTRACT G protein‐coupled receptors (GPCRs) that interact with the Wnt signaling pathway are pivotal for auditory system homeostasis, as they orchestrate inner ear development, hair cell (HC) regeneration, and hearing preservation. Frizzled (FZD) receptors, the core Wnt‐related GPCRs, bind Wnt ligands and co‐receptors (e.g., LRP5/6) to activate both ...
Liang Wang +3 more
wiley +1 more source
Med Research, EarlyView.ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang +22 more
wiley +1 more source
Nuclear Receptors in the Pathogenesis and Management of Inflammatory Bowel Disease
Mediators of Inflammation, 2019 Nuclear receptors (NRs) are ligand-dependent transcription factors that regulate the transcription of target genes. Previous epidemiological and genetic studies have documented the association of NRs with the risk of inflammatory bowel disease (IBD ...
Longgui Ning +3 more
doaj +1 more source
Sociobiology, 2014 Estrogen receptor-related receptors (ERRs) belong to a subfamily of orphan nuclear receptors where the proteins are closely related to the estrogen receptors (ERs) in structure.
Gengsi Xi
doaj +1 more source
Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders [PDF]
, 2016 Cytochrome P450 (CYP) enzymes for which there is no functional information are considered "orphan" CYPs. Previous studies showed that CYP20A1, an orphan, is expressed in human hippocampus and substantia nigra, and in zebrafish (Danio rerio) CYP20A1 ...
Akira Kubota +68 more
core +1 more source