Results 111 to 120 of about 48,614 (253)

From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies

Portal Hypertension &Cirrhosis, EarlyView.
This review examines the epidemiological shift from hepatitis B virus (HBV) to metabolic dysfunction‐associated steatotic liver disease (MASLD) as the leading cause of cirrhosis globally. It highlights the distinct pathogenic mechanisms between HBV and MASLD cirrhosis and discusses evolving diagnostic tools and therapeutic strategies tailored to the ...
Hanqi Yu, Hongfan Ding, Yang Huang, Haoze Cao, Yuan Ding, Weilin Wang   +5 more
wiley   +1 more source

Targeting nuclear receptors for NASH/MASH: From bench to bedside

Liver Research
The onset of metabolic dysfunction-associated steatohepatitis (MASH) or non-alcoholic steatohepatitis (NASH) represents a tipping point leading to liver injury and subsequent hepatic complications in the natural progression of what is now termed ...
Rohit A. Sinha
doaj   +1 more source

NR4A Receptors Differentially Regulate NF-κB Signaling in Myeloid Cells [PDF]

, 2017
Dysregulation of inflammatory responses is a hallmark of multiple diseases such as atherosclerosis and rheumatoid arthritis. As constitutively active transcription factors, NR4A nuclear receptors function to control the magnitude of inflammatory ...
Aherne, Bonta, Bren, Calvayrac, Calvayrac, Cicha, Crean, de Gaetano, Deng, Gruber, Hamers, Hamers, Hammond, Hanna, Hanna, Harant, Hilgendorf, Kurakula, Leeuwis, Lipson, Maijenburg, Manthey, Miao, Mix, Murphy, Nishioka, Palumbo-Zerr, Pearen, Pei, Pei, Phanish, Rodríguez-Calvo, Saijo, Tully, Wan, Wu, Zhan, Zhao, Zhao, Zhao   +39 more
core   +1 more source

Flavonoids in Nasal Therapeutics: Biological Activities, Delivery Challenges, and Formulation Strategies–A Systematic Review

Phytotherapy Research, EarlyView.
Overview of the therapeutic potential of flavonoids in nasal delivery systems, highlighting their benefits to the human nasal cavity, and applications in the treatment of respiratory and brain‐related diseases. ABSTRACT Flavonoids represent a significant group of secondary metabolites.
Jeniffer Viviana Ramirez Hernández, Sara Elis Bianchi, Flávia Nathiely Silveira Fachel, Elizandra Braganhol, Sheila Porto de Matos, Valquíria Linck Bassani   +5 more
wiley   +1 more source

MicroRNA-433 Dampens Glucocorticoid Receptor Signaling, Impacting Circadian Rhythm and Osteoblastic Gene Expression [PDF]

, 2016
FUNDING This work was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health [AR44877]; the National Institutes for Dental and Craniofacial Research [5T90DE21989]; a Grant-in-Aid award ...
Delany, Anne M, Dole, Neha S, Franceschetti, Tiziana, Hrdlicka, Henry C, Smith, Spenser S   +4 more
core   +1 more source

Genetic risk factors in Finnish patients with Fuchs endothelial corneal dystrophy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To study the genetic risk factors of Fuchs endothelial corneal dystrophy (FECD) in the Finnish population using hospital‐based and large biobank cohorts. Methods We genotyped a cohort of 107 Finnish patients with FECD for the primary associated genetic risk factor, the TCF4 (CTG)>50 expansion, and studied their clinical phenotype.
Inka‐Tuulevi Vähämäki, Annamari T. Immonen, Joel T. Rämö, Aino M. Jaakkola, Kari Krootila, Maria Kaukonen, FinnGen, Aarno Palotie, Hannes Lohi, Tero T. Kivelä, Joni A. Turunen   +10 more
wiley   +1 more source

Dopamine D2 antagonist-induced striatal Nur77 expression requires activation of mGlu5 receptors by cortical afferents

Frontiers in Pharmacology, 2012
Dopamine D2 receptor antagonists modulate gene transcription in the striatum. However, the molecular mechanism underlying this effect remains elusive. Here we used the expression of Nur77, a transcription factor of the orphan nuclear receptor family, as ...
Jérôme eMaheux, Michel eSt-Hilaire, David eVoyer, Emanuele eTirotta, Emiliana eBorrelli, Claude eRouillard, Pierre-Paul eRompré, Daniel eLévesque   +7 more
doaj   +1 more source

Correlation of Bile Acid Dynamics to Bulevirtide Response and Disease Severity in Patients With Hepatitis D

Alimentary Pharmacology &Therapeutics, EarlyView.
Bulevirtide increases bile acid levels in most patients; however, changes in bile acids do not predict virological response or adverse events, nor do they reflect treatment adherence. After discontinuation of bulevirtide, bile acid levels rapidly decline.
Marlene Hintersteininger, Michael Schwarz, Philipp Schwabl, Lukas Hartl, Lorenz Balcar, Benedikt Silvester Hofer, Georg Kramer, Christian Sebesta, Paul Thöne, Patrik Attalla, Michael Gschwantler, Michael Trauner, Mattias Mandorfer, Thomas Reiberger, Mathias Jachs   +14 more
wiley   +1 more source

Exploring the possibility of new ERR isoforms in primates and humans [PDF]

, 2004
only availableIt is well known that estrogen is a risk factor for breast cancer. Hence, understanding the relationship between estrogen and breast cancer is significant for physiological and disease related pathways. Traditional thought shows the effects
Gallimore, Malaika
core  

Nuclear Orphan Receptor COUP‐TFII in Reproduction

The FASEB Journal, 2008
COUP‐TFII (Chicken Ovalbumin Upstream Promoter‐Transcription Factor II) is an orphan nuclear receptor that belongs to the nuclear receptor superfamily. Genetic ablation of COUP‐TFII results in early embryonic lethality due to defects in angiogenesis and heart development.
Tsai, Sophia y, Kurihara, Isao, Lee, Dong-Kee, Qin, Jun, Petit, Fabrice G., Takamoto, Norio, Demayo, Francesco J., Tsai, Ming-Jer   +7 more
openaire   +2 more sources