Results 121 to 130 of about 48,614 (253)
British Journal of Haematology, EarlyView.Summary Immune thrombocytopenia (ITP) is a complex autoimmune disorder characterized by accelerated destruction of peripheral platelets and impaired megakaryopoiesis. While the cellular effectors, dysregulated T cells, hyperactive B cells and phagocytic macrophages are well characterized, the upstream epigenetic mechanisms orchestrating this ...
Zhenyu Liu +8 more
wiley +1 more source
Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?
British Journal of Pharmacology, EarlyView.Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli +7 more
wiley +1 more source
Nuclear Receptors and the Hidden Language of the Metabolome
CellsNuclear hormone receptors (NHRs) are a family of ligand-regulated transcription factors that control key aspects of development and physiology. The regulation of NHRs by ligands derived from metabolism or diet makes them excellent pharmacological targets,
Yujie Chen +4 more
doaj +1 more source
BMC Cancer, 2008 Background The human pregnane X receptor (hPXR) is an orphan nuclear receptor that induces transcription of response elements present in steroid-inducible cytochrome P-450 gene promoters. This activation requires the participation of retinoid X receptors
Fraile Benito +8 more
doaj +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
The Role of Adopted Orphan Nuclear Receptors in the Regulation of an Organic Anion Transporting Polypeptide 1B1 (OATP1B1) under the Action of Sex Hormones. [PDF]
Curr Issues Mol Biol, 2023 Shchulkin AV +4 more
europepmc +1 more source
Life After Care in Türkiye: A Scoping Review on Care Leavers
Child &Family Social Work, EarlyView.ABSTRACT The fragmented and dispersed knowledge base on care leavers in Türkiye makes it difficult to establish an evidence foundation for policy development and the improvement of practices in this field. This study aimed to comprehensively evaluate the existing body of knowledge on care leavers in Türkiye by compiling academic studies conducted ...
Hüsnünur Aslantürk +1 more
wiley +1 more source
Novel Potential Targets for Function-Promoting Therapies: Orphan Nuclear Receptors, Anti-inflammatory Drugs, Troponin Activators, Mas Receptor Agonists, and Urolithin A. [PDF]
J Gerontol A Biol Sci Med Sci, 2023 Dioh W +8 more
europepmc +1 more source
Nuclear Orphan Receptors Control Cholesterol Catabolism [PDF]
Cell, 1999 The multiple roles of metabolites and nuclear orphan receptors in regulating cholesterol homeostasis are summarized in Figure 3Figure 3. A complex interplay of intermediates and transcription factors serves to regulate the expression of dozens of genes, all in an attempt to control the levels of potentially toxic but essential hydrophobic molecules ...
openaire +2 more sources
From hepatic to hematopoietic: LRH‐1's expanding cellular repertoire to the immune system
The FEBS Journal, EarlyView.The nuclear receptor LRH‐1 is a well‐characterized regulator of endodermal tissue. Yet, increasing evidence indicates that LRH‐1, although expressed at low levels, is also a critical regulator of the hematopoietic system. LRH‐1 regulates the immune system by contributing to immune cell‐specific functions.
Lukas Meisinger +3 more
wiley +1 more source