Results 41 to 50 of about 48,614 (253)
Molecular pharmacokinetic determinants of anticancer kinase inhibitors in humans
Oncology Reviews, 2011 This review presents the published data regarding the molecular determinants (drug metabolizing enzymes, drug transporters and orphan nuclear receptors) of approved anticancer kinase inhibitors pharmacokinetics in humans.
Julie Scholler, Dominique Leveque
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Orphan nuclear receptors in angiogenesis and follicular development [PDF]
Reproduction, 2021 Abstract Orphan nuclear receptors (ONRs) are a subset of the nuclear receptor family that lacks known endogenous ligands. Among 48 nuclear receptors identified in humans, 25 are classified as ONRs. They function as transcription factors and control the expression of a wide range of genes to regulate metabolism, fertility, immunity ...
Adrian, Guzmán +2 more
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PLoS ONE, 2016 Many genes are differentially expressed in the cortex of people with schizophrenia, implicating factors that control transcription more generally. Hormone nuclear receptors dimerize to coordinate context-dependent changes in gene expression.
Susan M Corley +3 more
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Antioxidants, 2021 Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone receptor superfamily. Originally described as “orphan nuclear receptors”, they can bind both natural and synthetic ligands acting as agonists or antagonists.
Giuliana Muzio +2 more
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Peripheral and central mechanisms involved in hormonal control of male and female reproduction [PDF]
, 2016 Reproduction involves the integration of hormonal signals acting across multiple systems togenerate a synchronized physiological output. A critical component of reproduction is the luteinizinghormone (LH) surge, which is mediated by estradiol (E2) and ...
Bentley, G. E. +6 more
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The Orphan Nuclear Receptor TR4 Is a Vitamin A-activated Nuclear Receptor [PDF]
Journal of Biological Chemistry, 2011 Testicular receptors 2 and 4 (TR2/4) constitute a subgroup of orphan nuclear receptors that play important roles in spermatogenesis, lipid and lipoprotein regulation, and the development of the central nervous system. Currently, little is known about the structural features and the ligand regulation of these receptors.
X Edward, Zhou +8 more
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Adopted orphans as regulators of inflammation, immunity and skeletal homeostasis
Swiss Medical Weekly, 2014 Adopted orphan nuclear receptors, such as peroxisome proliferator-activated receptors (PPARs) and liver X receptors (LXRs), have emerged as key regulators of inflammation and immunity and likewise control skeletal homeostasis.
Natacha Ipseiz +3 more
doaj +1 more source
Nuclear Receptor RORα/γ: Exciting Modulators in Metabolic Syndrome and Related Disorders
Frontiers in Nutrition, 2022 Under the influences of modern lifestyle, metabolic syndromes (MetS), including insulin resistance, obesity, and fatty liver, featuring a worldwide chronic disease, greatly raise the risk of type 2 diabetes, heart disease, and stroke.
Haotian Gu +8 more
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Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease [PDF]
, 2009 Traditionally, Crohn's disease has been associated with a Th1 cytokine profile, while Th2 cytokines are modulators of ulcerative colitis. This concept has been challenged by the description of tolerising regulatory T cells (Treg) and by proinflammatory ...
Brand, Stephan
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A Role of the Bile Salt Receptor FXR in Atherosclerosis [PDF]
, 2010 This study reviews current insights into the role of bile salts and bile salt receptors on the progression and regression of atherosclerosis. Bile salts have emerged as important modifiers of lipid and energy metabolism.
Groen, A.K. +3 more
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