Results 21 to 30 of about 48,394 (192)

Estrogen-related receptor α (ERRα) : a novel target in type 2 diabetes [PDF]

, 2005
Recent studies have shown that reduced mitochondrial content and function in skeletal muscle are common features of type 2 diabetes. Here, we review the molecular mechanisms involved in the regulation of mitochondrial genes in skeletal muscle, focusing ...
Handschin, C., Mootha, V. K.
core   +1 more source

Estrogen-related receptors alpha, beta and gamma expression and function is associated with transcriptional repressor EZH2 in breast carcinoma

BMC Cancer, 2018
Background Orphan nuclear receptors ERRα, ERRβ and ERRγ that belong to NR3B or type IV nuclear receptor family are well studied for their role in breast cancer pathophysiology.
Kanchan Kumari, Amit K. Adhya, Arabinda Kumar Rath, P. B. Reddy, Sandip K. Mishra   +4 more
doaj   +1 more source

Independent elaboration of steroid hormone signaling pathways in Metazoans [PDF]

, 2009
Steroid hormones regulate many physiological processes in vertebrates, nematodes and arthropods through binding to nuclear receptors (NR), a metazoan-specific family of ligand-activated transcription factors.
Barbara A. Demeneix, Chantal Dauphin-Villemant, Gabriel V. Markov, Michael E. Baker, Raquel Tavares, Vincent Laudet   +5 more
core   +4 more sources

Nuclear receptors in vascular biology [PDF]

, 2015
Nuclear receptors sense a wide range of steroids and hormones (estrogens, progesterone, androgens, glucocorticoid, and mineralocorticoid), vitamins (A and D), lipid metabolites, carbohydrates, and xenobiotics.
A Chawla, A McCurley, AA Hamers, AL Bookout, B Fisslthaler, BG Hoebel, C McCarthy, C Zhou, CH Lee, CK Glass, CK Huang, CT Lee, D Bishop-Bailey, D Bishop-Bailey, David Bishop-Bailey, DP Edwards, E Gerlach, F Akbiyik, FA Pereira, FL Wynne, FY Ali, G Pascual, I Dussault, I Spoletini, J He, J Qin, J Sonoda, J Xiang, K Spruiell, KE Swales, L Calza, L Li, L Piqueras, LA Moraes, LA Moraes, LJ Jonk, LR You, M Kaushik, M Matic, N Albermann, N Schafer, N Takamoto, Q Qin, R Zhao, S Asgary, S Chakrabarti, S Marino De, S Stein, SA Kliewer, V Zoete, W El-Sankary, WC Lau, X Wang, Y Ma, Y Sui, Y Sui, YW Hu   +56 more
core   +3 more sources

Nuclear Receptors as Autophagy-Based Antimicrobial Therapeutics

Cells, 2020
Autophagy is an intracellular process that targets intracellular pathogens for lysosomal degradation. Autophagy is tightly controlled at transcriptional and post-translational levels.
Prashanta Silwal, Seungwha Paik, Sang Min Jeon, Eun-Kyeong Jo   +3 more
doaj   +1 more source

A Review of Melatonin, Its Receptors and Drugs

Eurasian Journal of Medicine, 2019
After a Turkish scientist took Nobel Prize due to his contributions to understand clock genes, melatonin, closely related to these genes, may begin to shine.
Mucahit Emet, Halil Ozcan, Lutfu Ozel, Muhammed Yayla, Zekai Halici, Ahmet Hacimuftuoglu   +5 more
doaj   +1 more source

Role of the Orphan Nuclear Receptor NR4A Family in T-Cell Biology

Frontiers in Endocrinology, 2021
The nuclear orphan receptors NR4A1, NR4A2, and NR4A3 are immediate early genes that are induced by various signals. They act as transcription factors and their activity is not regulated by ligand binding and are thus regulated via their expression levels.
Livia Odagiu, Livia Odagiu, Julia May, Salix Boulet, Troy A. Baldwin, Nathalie Labrecque, Nathalie Labrecque, Nathalie Labrecque   +7 more
doaj   +1 more source

Evidence for gliadin antibodies as causative agents in schizophrenia. [PDF]

, 2010
Antibodies to gliadin, a component of gluten, have frequently been reported in schizophrenia. Highly immunogenic B cell epitopes along its length are homologous to numerous proteins relevant to schizophrenia, including members of the DISC1 interactome ...
Chris J. Carter
core   +2 more sources

Molecular pharmacokinetic determinants of anticancer kinase inhibitors in humans

Oncology Reviews, 2011
This review presents the published data regarding the molecular determinants (drug metabolizing enzymes, drug transporters and orphan nuclear receptors) of approved anticancer kinase inhibitors pharmacokinetics in humans.
Julie Scholler, Dominique Leveque
doaj   +1 more source

A Role of the Bile Salt Receptor FXR in Atherosclerosis [PDF]

, 2010
This study reviews current insights into the role of bile salts and bile salt receptors on the progression and regression of atherosclerosis. Bile salts have emerged as important modifiers of lipid and energy metabolism.
Groen, A.K., Hageman, J., Herrema, H.J., Kuipers, F.   +3 more
core   +3 more sources