Results 11 to 20 of about 48,394 (192)

Orphan Nuclear Receptors: From Gene to Function* [PDF]

Endocrine Reviews, 1999
I. Introduction II. Nuclear Receptors: General Concepts A. Anatomy of nuclear receptors B. Mechanisms of action III. Orphan Nuclear Receptors A. Definition B. Nomenclature C. Structural and functional diversity IV. Novel Hormone Response Systems: RXR and Its Heterodimeric Partners A. RXR: rexinoids B. PPAR: multiple ligands, multiple functions C.
Vincent Giguère
openaire   +4 more sources

Nuclear Orphan Receptors Control Cholesterol Catabolism [PDF]

Cell, 1999
The multiple roles of metabolites and nuclear orphan receptors in regulating cholesterol homeostasis are summarized in Figure 3Figure 3. A complex interplay of intermediates and transcription factors serves to regulate the expression of dozens of genes, all in an attempt to control the levels of potentially toxic but essential hydrophobic molecules ...
David W Russell
openaire   +4 more sources

NR4A Orphan Nuclear Receptors in Cardiovascular Biology. [PDF]

Drug Discov Today Dis Mech, 2009
The NR4A orphan nuclear receptor subfamily is comprised of the highly homologous receptors Nur77 (NR4A1), Nurr1 (NR4A2), and NOR1 (NR4A3). These evolutionarily conserved and ancient receptors function as ligand-independent transcription factors that regulate the expression of overlapping target genes. As early response genes, the basal expression level
Zhao Y, Bruemmer D.
europepmc   +4 more sources

Orphan nuclear receptors [PDF]

Br J Pharmacol, 2009
europepmc   +3 more sources

The nuclear receptors of Biomphalaria glabrata and Lottia gigantea: Implications for developing new model organisms [PDF]

, 2015
© 2015 Kaur et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Antebi, A Aranda, A Bateman, A Daniel, A De Groot, A Heyland, A Le Maire, AC Chung, AE Lockyer, AE Lockyer, AE Lockyer, AE Lockyer, AE Lockyer, AE Sluder, AK Allen, AM Puinean, Anne E. Lockyer, AP Scott, AP Scott, B Stone, C Shiff, C Thummel, C Tyler, Catherine S. Jones, CB Burge, CJ Carter, CK Glass, CL Hultin, CM Adema, CM Adema, D Bouton, D Jones, D Lima, D Stange, DH Huson, DL Whitehead, E Enmark, Edwin J. Routledge, ER Levin, ES Ford, F Abascal, F Bonneton, F Ronquist, FM Sladek, G Benoit, G Escobedo, G Mitta, GN Eick, GV Markov, GV Markov, H Ueda, H Urushitani, H Zhang, H-R Koehler, I Letunic, J Auwerx, J Gutierrez-Mazariegos, J Keay, J Keay, J Oehlmann, J-M Wurtz, JT Bridgham, JT Bridgham, JW Thornton, K King-Jones, K King-Jones, K Tamura, L Chitsulo, L de F Tallarico, L-M Chen, LA Hertel, Leslie R. Noble, LFC Castro, LFC Castro, LN Rapado, M Garcia, M Kajiwara, M Knight, M Laguerre, M Pawlak, M Robinson-Rechavi, M Robinson-Rechavi, M Robinson-Rechavi, M Tillmann, M-JWA Schiffelers, MD Adams, ME Baker, ME Baker, MI Snow, N Raghavan, NE-SE-S Omran, O Simakov, P Matthiessen, P Matthiessen, P Thomas, PC Hanington, PC Hanington, PD Thomas, Peter P. Fong, PL Bardet, R Bannister, R Bannister, R Lafont, RA Velarde, RJ Greenspan, RM Sternberg, RM Sternberg, RT Yu, S Bertrand, S Kliewer, S Kumkate, S Pascoal, S Vogeler, SA Thomson, Satwant Kaur, SF Altschul, SH Golden, Susan Jobling, T Li, T Matsumoto, T Simoncini, TH Lindblom, TT Schug, W Wu, W Wu, W Wu, W Wu, X Ding, X Mu, Y Katsu, YG Jiang, ZD Zhang   +131 more
core   +11 more sources

Nuclear Receptors: Lonesome orphans [PDF]

Current Biology, 1995
Nuclear receptors typically bind to DNA as homodimers or heterodimers, but increasing numbers of orphan receptors have been identified that bind DNA as monomers.
Laudet, Vincent, Adelmant, Guillaume
openaire   +2 more sources

Nuclear Hormone Receptors and Their Ligands: Metabolites in Control of Transcription

Cells, 2020
Nuclear hormone receptors are a family of transcription factors regulated by small molecules derived from the endogenous metabolism or diet. There are forty-eight nuclear hormone receptors in the human genome, twenty of which are still orphans.
Lian Jing Tao, Dong Eun Seo, Benjamin Jackson, Natalia B. Ivanova, Fabio Rinaldo Santori   +4 more
doaj   +1 more source

Small Heterodimer Partner and Innate Immune Regulation [PDF]

Endocrinology and Metabolism, 2016
The nuclear receptor superfamily consists of the steroid and non-steroid hormone receptors and the orphan nuclear receptors. Small heterodimer partner (SHP) is an orphan family nuclear receptor that plays an essential role in the regulation of glucose ...
Jae-Min Yuk, Hyo Sun Jin, Eun-Kyeong Jo
doaj   +1 more source

CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR) [PDF]

, 2000
Nuclear receptors constitute a large family of ligand-modulated transcription factors that mediate cellular responses to small lipophilic molecules, including steroids, retinoids, fatty acids, and exogenous ligands. Orphan nuclear receptors with no known
Handschin, C., Podvinec, M., Meyer, U. A.   +2 more
core   +1 more source

Identification of an endogenous ligand bound to a native orphan nuclear receptor. [PDF]

PLoS ONE, 2009
Orphan nuclear receptors have been instrumental in identifying novel signaling pathways and therapeutic targets. However, identification of ligands for these receptors has often been based on random compound screens or other biased approaches.
Xiaohui Yuan, Tuong Chi Ta, Min Lin, Jane R Evans, Yinchen Dong, Eugene Bolotin, Mark A Sherman, Barry M Forman, Frances M Sladek   +8 more
doaj   +1 more source