Results 31 to 40 of about 48,394 (192)
PLoS ONE, 2016 Many genes are differentially expressed in the cortex of people with schizophrenia, implicating factors that control transcription more generally. Hormone nuclear receptors dimerize to coordinate context-dependent changes in gene expression.
Susan M Corley +3 more
doaj +1 more source
Antioxidants, 2021 Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone receptor superfamily. Originally described as “orphan nuclear receptors”, they can bind both natural and synthetic ligands acting as agonists or antagonists.
Giuliana Muzio +2 more
doaj +1 more source
An autoregulatory loop controlling orphan nuclear receptor DAX-1 gene expression by orphan nuclear receptor ERRγ [PDF]
Nucleic Acids Research, 2005 The estrogen receptor-related receptor gamma (ERRgamma/ERR3/NR3B3) is a member of the nuclear receptor superfamily that activates transcription in the absence of ligand. However, the detailed mechanism of gene regulation by ERRgamma is not fully understood.
Park, Yun-Yong +6 more
openaire +4 more sources
Peripheral and central mechanisms involved in hormonal control of male and female reproduction [PDF]
, 2016 Reproduction involves the integration of hormonal signals acting across multiple systems togenerate a synchronized physiological output. A critical component of reproduction is the luteinizinghormone (LH) surge, which is mediated by estradiol (E2) and ...
Bentley, G. E. +6 more
core +1 more source
Adopted orphans as regulators of inflammation, immunity and skeletal homeostasis
Swiss Medical Weekly, 2014 Adopted orphan nuclear receptors, such as peroxisome proliferator-activated receptors (PPARs) and liver X receptors (LXRs), have emerged as key regulators of inflammation and immunity and likewise control skeletal homeostasis.
Natacha Ipseiz +3 more
doaj +1 more source
Nuclear Receptor RORα/γ: Exciting Modulators in Metabolic Syndrome and Related Disorders
Frontiers in Nutrition, 2022 Under the influences of modern lifestyle, metabolic syndromes (MetS), including insulin resistance, obesity, and fatty liver, featuring a worldwide chronic disease, greatly raise the risk of type 2 diabetes, heart disease, and stroke.
Haotian Gu +8 more
doaj +1 more source
LGR5 is associated with tumor aggressiveness in papillary thyroid cancer. [PDF]
, 2015 PurposeLeucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) is a cancer stem cell marker and a down-stream target in Wnt/β-catenin signaling. In human papillary thyroid cancer (PTC), over activation of Wnt/β-catenin has been associated with
Diehl, Anna Mae +4 more
core +3 more sources
Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease [PDF]
, 2009 Traditionally, Crohn's disease has been associated with a Th1 cytokine profile, while Th2 cytokines are modulators of ulcerative colitis. This concept has been challenged by the description of tolerising regulatory T cells (Treg) and by proinflammatory ...
Brand, Stephan
core +1 more source
Coactivators for the Orphan Nuclear Receptor RORα [PDF]
Molecular Endocrinology, 1999 A mutation in the nuclear orphan receptor RORalpha results in a severe impairment of cerebellar development by unknown mechanisms. We have shown previously that RORalpha contains a strong constitutive activation domain in its C terminus. We therefore searched for mammalian RORalpha coactivators using the minimal activation domain as bait in a two ...
G B, Atkins +5 more
openaire +2 more sources
Endocannabinoid system and anticancer properties of cannabinoids [PDF]
, 2016 Cannabinoids impact human body by binding to cannabinoids receptors (CB1 and CB2). The two main phytocannabinoids are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD).
Nowak, Agnieszka +3 more
core +2 more sources