Results 71 to 80 of about 24,134 (239)
Nurr1 dependent regulation of pro-inflammatory mediators in immortalised synovial fibroblasts
Journal of Inflammation, 2005 Background Nurr1 is an orphan member of the nuclear receptor superfamily; these orphan receptors are a group for which a ligand has yet to be identified.
Parker Andrew E +6 more
doaj +1 more source
An Orphan Nuclear Receptor Finds a Home [PDF]
Molecular Cell, 2010 In this issue of Molecular Cell, Lee et al. (2010) show that the retinoic acid receptor-related orphan receptor alpha (RORalpha) can suppress the Wnt/beta-catenin signaling pathway in a Wnt5a- and PKC-dependent manner that does not alter beta-catenin stabilization or the recruitment of beta-catenin to Wnt target promoters.
openaire +2 more sources
Emerging Next-Generation Target for Cancer Immunotherapy Research: The Orphan Nuclear Receptor NR2F6 [PDF]
, 2021 Victoria Klepsch +2 more
openalex +1 more source
Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases
BMEMat, EarlyView.This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou +6 more
wiley +1 more source
Nuclear Orphan Receptor COUP‐TFII in Reproduction
The FASEB Journal, 2008 COUP‐TFII (Chicken Ovalbumin Upstream Promoter‐Transcription Factor II) is an orphan nuclear receptor that belongs to the nuclear receptor superfamily. Genetic ablation of COUP‐TFII results in early embryonic lethality due to defects in angiogenesis and heart development.
Tsai, Sophia y +7 more
openaire +2 more sources
Sociobiology, 2014 Estrogen receptor-related receptors (ERRs) belong to a subfamily of orphan nuclear receptors where the proteins are closely related to the estrogen receptors (ERs) in structure.
Gengsi Xi
doaj +1 more source
Gut microbiome‐derived metabolites show promise in cancer research and therapy
Interdisciplinary Medicine, EarlyView.The metabolites produced by the gut microbiome, which are subject to regulation by multiple factors, play a pivotal role in the progression of various types of cancer. These metabolites not only function as potential biomarkers for the early detection and monitoring of tumor development, but also actively participate in cancer therapeutic processes ...
Kangjie Yang +4 more
wiley +1 more source
Targeting nuclear receptors for NASH/MASH: From bench to bedside
Liver ResearchThe onset of metabolic dysfunction-associated steatohepatitis (MASH) or non-alcoholic steatohepatitis (NASH) represents a tipping point leading to liver injury and subsequent hepatic complications in the natural progression of what is now termed ...
Rohit A. Sinha
doaj +1 more source
Nuclear Receptors in the Pathogenesis and Management of Inflammatory Bowel Disease
Mediators of Inflammation, 2019 Nuclear receptors (NRs) are ligand-dependent transcription factors that regulate the transcription of target genes. Previous epidemiological and genetic studies have documented the association of NRs with the risk of inflammatory bowel disease (IBD ...
Longgui Ning +3 more
doaj +1 more source
Med Research, EarlyView.ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang +22 more
wiley +1 more source