Results 1 to 10 of about 3,847 (223)

Case of Human Orthohantavirus Infection, Michigan, USA, 2021. [PDF]

Emerg Infect Dis
Orthohantaviruses cause hantavirus cardiopulmonary syndrome; most cases occur in the southwest region of the United States. We discuss a clinical case of orthohantavirus infection in a 65-year-old woman in Michigan and the phylogeographic link of partial
Goodfellow SM, Nofchissey RA, Arsnoe D, Ye C, Lee S, Park J, Kim WK, Chandran K, Whitmer SLM, Klena JD, Dyal JW, Shoemaker T, Riner D, Stobierski MG, Signs K, Bradfute SB.   +15 more
europepmc   +8 more sources

Serological Evidence of Human Orthohantavirus Infections in Barbados, 2008 to 2016 [PDF]

Pathogens, 2021
Background: Hantavirus pulmonary syndrome (HPS) is well-known in South and North America; however, not enough data exist for the Caribbean. The first report of clinical orthohantavirus infection was obtained in Barbados, but no other evidence of clinical
Kirk Osmond Douglas, Thelma Alafia Samuels, Rommel Iheozor-Ejiofor, Olli Vapalahti, Tarja Sironen, Marquita Gittens-St. Hilaire   +5 more
doaj   +10 more sources

Novel Orthohantavirus Associated with Hantavirus Pulmonary Syndrome in Northern Argentina [PDF]

Viruses
In this work, we performed the genetic characterization of a new variant of orthohantavirus associated with a fatal case of hantavirus pulmonary syndrome, outside the known endemic region, in northwestern Argentina.
Carla M. Bellomo, Sebastian Kehl, Daniel Oscar Alonso, Walter López, Flavia Cassinelli, Rocío María Coelho, Gabriela Bravo, Sara Aguirre, Marcela Dib, Natalia Periolo, Concepción Toscano, José Gil, Francisco García Campos, Ignacio Ferro, Valeria Paula Martinez   +14 more
doaj   +4 more sources

Increased Heparanase Levels in Urine during Acute Puumala Orthohantavirus Infection Are Associated with Disease Severity [PDF]

Viruses, 2022
Old–world orthohantaviruses cause hemorrhagic fever with renal syndrome (HFRS), characterized by acute kidney injury (AKI) with transient proteinuria. It seems plausible that proteinuria during acute HFRS is mediated by the disruption of the glomerular ...
Luz E. Cabrera, Constanze Schmotz, Moin A. Saleem, Sanna Lehtonen, Olli Vapalahti, Antti Vaheri, Satu Mäkelä, Jukka Mustonen, Tomas Strandin   +8 more
doaj   +10 more sources

Use of a diagnostic Puumala virus real-time RT-PCR in an orthohantavirus endemic region in the Netherlands [PDF]

Microbiology Spectrum
Laboratory diagnosis of orthohantavirus infection is primarily based on serology. However, for a confirmed serological diagnosis, evaluation of a follow-up serum sample is essential, which is time consuming and causes delay.
Felix Geeraedts, Mariska Wevers, Froukje Bosma, Maria de Boer, J. N. Brinkman, Corine Delsing, Corine GeurtsvanKessel, Barry Rockx, Adri van der Zanden, Gozewijn D. Laverman   +9 more
doaj   +3 more sources

A pan-orthohantavirus human lung xenograft mouse model and its utility for preclinical studies. [PDF]

PLoS Pathogens
Orthohantaviruses are emerging zoonotic viruses that can infect humans via the respiratory tract. There is an unmet need for an in vivo model to study infection of different orthohantaviruses in physiologically relevant tissue and to assess the efficacy ...
Melanie Rissmann, Danny Noack, Thomas M Spliethof, Vincent P Vaes, Rianne Stam, Peter van Run, Jordan J Clark, Georges M G M Verjans, Bart L Haagmans, Florian Krammer, Marion P G Koopmans, Judith M A van den Brand, Barry Rockx   +12 more
doaj   +3 more sources

Characterisation of Orthohantavirus Serotypes in Human Infections in Kazakhstan [PDF]

Viruses
Orthohantavirus infection is a zoonotic disease transmitted to humans through contact with infected rodents. In Eurasia, Old World Orthohantaviruses can cause haemorrhagic fever with renal syndrome (HFRS), while in the Americas, New World ...
Nur Tukhanova, Anna Shin, Abhishek Bakuli, Lyazzat Yeraliyeva, Nurbek Maikanov, Guenter Froeschl, Zauresh Zhumadilova, Gulnara Tokmurziyeva, Edith Wagner, Sandra Essbauer, Lukas Peintner   +10 more
doaj   +3 more sources

Designing a Conserved Immunogenic Peptide Construct from the Nucleocapsid Protein of Puumala orthohantavirus [PDF]

Viruses
Puumala orthohantavirus (PUUV) is an emerging zoonotic virus endemic to Europe and Russia that causes nephropathia epidemica, a mild form of hemorrhagic fever with renal syndrome (HFRS).
Ayushi Sehgal, Diksha Sharma, Neha Kaushal, Yogita Gupta, Ekaterina Martynova, Emmanuel Kabwe, Sara Chandy, Albert Rizvanov, Svetlana Khaiboullina, Manoj Baranwal   +9 more
doaj   +3 more sources

Serological Evidence of Multiple Zoonotic Viral Infections among Wild Rodents in Barbados [PDF]

Pathogens, 2021
Background: Rodents are reservoirs for several zoonotic pathogens that can cause human infectious diseases, including orthohantaviruses, mammarenaviruses and orthopoxviruses.
Kirk Osmond Douglas, Claire Cayol, Kristian Michael Forbes, Thelma Alafia Samuels, Olli Vapalahti, Tarja Sironen, Marquita Gittens-St. Hilaire   +6 more
doaj   +6 more sources

Infection with New York Orthohantavirus and Associated Respiratory Failure and Multiple Cerebral Complications [PDF]

Emerging Infectious Diseases, 2019
We report a case of infection with New York orthohantavirus in a woman who showed renal impairment and hemorrhage, complicated by hydrocephalus, in Long Island, New York, USA.
Rajeev Fernando, David Capone, Susan Elrich, Raymond Mantovani, Luther Quarles, Alison D’Amato, Nathan Lowe, Ashwin Malhotra, Teresa Khoo, Sara Zufan, Maria Morales-Betoulle, Shelley M. Brown, Deborah Cannon, James C. Graziano, John D. Klena, Shannon Whitmer, Stuart T. Nichol, Paul Strachan, Bernard C. Camins, Luis A. Marcos   +19 more
doaj   +2 more sources