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Orthohantavirus Replication in the Context of Innate Immunity

Viruses, 2023
Orthohantaviruses are rodent-borne, negative-sense RNA viruses that are capable of causing severe vascular disease in humans. Over the course of viral evolution, these viruses have tailored their replication cycles in such a way as to avoid and/or ...
Alison Kell, Autumn Lapointe, Michael Gale   +2 more
exaly   +5 more sources

Characterisation of Orthohantavirus Serotypes in Human Infections in Kazakhstan [PDF]

Viruses
Orthohantavirus infection is a zoonotic disease transmitted to humans through contact with infected rodents. In Eurasia, Old World Orthohantaviruses can cause haemorrhagic fever with renal syndrome (HFRS), while in the Americas, New World ...
Nur Tukhanova, Anna Shin, Abhishek Bakuli, Lyazzat Yeraliyeva, Nurbek Maikanov, Guenter Froeschl, Zauresh Zhumadilova, Gulnara Tokmurziyeva, Edith Wagner, Sandra Essbauer, Lukas Peintner   +10 more
doaj   +4 more sources

The Immune Correlates of Orthohantavirus Vaccine [PDF]

Vaccines, 2021
Zoonotic transmission of orthohantaviruses from rodent reservoirs to humans has been the cause of severe fatalities. Human infections are reported worldwide, but vaccines have been approved only in China and Korea. Orthohantavirus vaccine development has
Joon-Yong Bae, Jin Il Kim, Mee Sook Park, Gee Eun Lee, Heedo Park, Ki-Joon Song, Man-Seong Park   +6 more
doaj   +3 more sources

Orthohantavirus Infection Mimicking Acute Viral Hepatitis: An Underrecognized Clinical Presentation [PDF]

Pathogens
Orthohantavirus infections are classically associated with hemorrhagic fever with renal syndrome (HFRS) in Eurasia and hantavirus cardiopulmonary syndrome (HCPS) in the Americas.
Francesco De Maria, Francesco Branda, Giancarlo Ceccarelli, Fabio Scarpa, Massimo Ciccozzi, Alessandro Russo   +5 more
doaj   +2 more sources

Temporal Dynamics of Viremia in Hemorrhagic Fever With Renal Syndrome Patients. [PDF]

J Med Virol
ABSTRACT The pathogenesis of hemorrhagic fever with renal syndrome (HFRS) remains incompletely understood. Currently, the clinical diagnosis of HFRS primarily relies on epidemiological history and clinical presentation, while the confirmation of HFRS depends mainly on the detection of hemorrhagic fever antibodies.
Ma S, Zhan J, Fan C, Zheng X, Du H, Wang L, Jiang H.   +6 more
europepmc   +2 more sources

Pathogenicity and virulence of Rodent-Borne Orthohantaviruses [PDF]

Virulence
The Orthohantavirus genus in the family Hantaviridae includes viruses that cause zoonotic diseases in humans known as hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). Exposure of humans to these viruses occurs through
Shannon L. Taylor, Connie S. Schmaljohn, Evan P. Williams, Colleen B. Jonsson   +3 more
doaj   +2 more sources

A pan-orthohantavirus human lung xenograft mouse model and its utility for preclinical studies. [PDF]

PLoS Pathogens
Orthohantaviruses are emerging zoonotic viruses that can infect humans via the respiratory tract. There is an unmet need for an in vivo model to study infection of different orthohantaviruses in physiologically relevant tissue and to assess the efficacy ...
Melanie Rissmann, Danny Noack, Thomas M Spliethof, Vincent P Vaes, Rianne Stam, Peter van Run, Jordan J Clark, Georges M G M Verjans, Bart L Haagmans, Florian Krammer, Marion P G Koopmans, Judith M A van den Brand, Barry Rockx   +12 more
doaj   +2 more sources

Hantavirus is Associated With Open Developed Areas and Arid Climates, Highlighting Increased Risk in the Western United States. [PDF]

Transbound Emerg Dis
In the United States, hantaviruses can cause hantavirus pulmonary syndrome (HPS) in humans, an acute respiratory illness with a high mortality rate. Most people contract HPS from exposure to infected rodent excrement. The interannual dynamics of hantavirus transmission are tied to both environmental and human‐related factors, including changes in ...
Gorris ME, Whitesell A, Telford C, Shoemaker T, Bartlow AW.   +4 more
europepmc   +2 more sources

Human Orthohantavirus Infections: A Narrative Review

Pathogens
Orthohantaviruses are zoonotic pathogens belonging to the family Hantaviridae and are responsible for significant human disease. These infections are characterized by acute systemic illness, vascular dysfunction, and, in severe cases, hemorrhage and ...
Vitor Duque
doaj   +2 more sources

Orthohantavirus Spp. – Review Of Genus [PDF]

Postępy Mikrobiologii - Advancements of Microbiology, 2021
Abstract The infections caused by orthohantaviruses were already known in the Middle Ages as “English sweats.” There are two main diseases caused by these viruses – HPS (hantavirus pulmonary syndrome) and HFRS (hemorrhagic fever with renal syndrome). Rodents are the main reservoir of these microorganisms, and humans usually catch them
Leis, Kamil, Kaczor, Patryk, Baska, Aleksandra, Kazik, Jakub, Kolan, Michalina, Grudlewska-Buda, Katarzyna, Wiktorczyk, Natalia, Skowron, Krzysztof   +7 more
openaire   +2 more sources