Results 21 to 30 of about 7,320 (164)

A pan-orthohantavirus human lung xenograft mouse model and its utility for preclinical studies. [PDF]

PLoS Pathogens
Orthohantaviruses are emerging zoonotic viruses that can infect humans via the respiratory tract. There is an unmet need for an in vivo model to study infection of different orthohantaviruses in physiologically relevant tissue and to assess the efficacy ...
Melanie Rissmann, Danny Noack, Thomas M Spliethof, Vincent P Vaes, Rianne Stam, Peter van Run, Jordan J Clark, Georges M G M Verjans, Bart L Haagmans, Florian Krammer, Marion P G Koopmans, Judith M A van den Brand, Barry Rockx   +12 more
doaj   +2 more sources

5,6-Dichloro-2-Phenyl-Benzotriazoles: New Potent Inhibitors of Orthohantavirus [PDF]

Viruses, 2020
Orthohantaviruses, previously known as hantaviruses (family Hantaviridae, order Bunyavirales), are emerging zoonoses hosted by different rodent and insectivore species. Orthohantaviruses are transmitted by aerosolized excreta (urine, saliva and feces) of
Giuseppina Sanna, Sandra Piras, Silvia Madeddu, Bernardetta Busonera, Boris Klempa, Paola Corona, Roberta Ibba, Gabriele Murineddu, Antonio Carta, Roberta Loddo   +9 more
doaj   +4 more sources

Pathogenicity and virulence of Rodent-Borne Orthohantaviruses [PDF]

Virulence
The Orthohantavirus genus in the family Hantaviridae includes viruses that cause zoonotic diseases in humans known as hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). Exposure of humans to these viruses occurs through
Shannon L. Taylor, Connie S. Schmaljohn, Evan P. Williams, Colleen B. Jonsson   +3 more
doaj   +2 more sources

Interactions Between Hantavirus Nucleoprotein and Glycoproteins: A Quantitative Fluorescence Microscopy Study [PDF]

Viruses
Orthohantaviruses are tri-segmented negative-sense RNA viruses that can cause severe pathologies in humans. Currently, limited information exists on the molecular interactions driving orthohantavirus assembly in infected cells.
Amit Koikkarah Aji, Titas Mandal, Salvatore Chiantia   +2 more
doaj   +2 more sources

Novel Orthohantavirus Associated with Hantavirus Pulmonary Syndrome in Northern Argentina [PDF]

Viruses
In this work, we performed the genetic characterization of a new variant of orthohantavirus associated with a fatal case of hantavirus pulmonary syndrome, outside the known endemic region, in northwestern Argentina.
Carla M. Bellomo, Sebastian Kehl, Daniel Oscar Alonso, Walter López, Flavia Cassinelli, Rocío María Coelho, Gabriela Bravo, Sara Aguirre, Marcela Dib, Natalia Periolo, Concepción Toscano, José Gil, Francisco García Campos, Ignacio Ferro, Valeria Paula Martinez   +14 more
doaj   +2 more sources

Complex History of Codiversification and Host Switching of a Newfound Soricid-Borne Orthohantavirus in North America

Viruses, 2019
Orthohantaviruses are tightly linked to the ecology and evolutionary history of their mammalian hosts. We hypothesized that in regions with dramatic climate shifts throughout the Quaternary, orthohantavirus diversity and evolution are shaped by dynamic ...
Luis A Ruedas, Joseph A. Cook, Richard
exaly   +3 more sources

An Improved Workflow for the Quantification of Orthohantavirus Infection Using Automated Imaging and Flow Cytometry

Viruses
Determination of the infectious titer is a central requirement when working with pathogenic viruses. The plaque or focus assay is a commonly used but labor- and time-consuming approach for determining the infectious titer of orthohantavirus samples.
Christian Sieben, Laura Menke
exaly   +3 more sources

Clinical and Molecular Epidemiology of Hemorrhagic Fever with Renal Syndrome Caused by Orthohantaviruses in Xiangyun County, Dali Prefecture, Yunnan Province, China

Vaccines, 2023
Hemorrhagic fever with renal syndrome (HFRS) is a zoonotic disease transmitted by several rodent species. We obtained clinical data of HFRS patients from the medical records of the People’s Hospital of Xiangyun County in Dali Prefecture from July 2019 to
Hao Huang, Meng Fu, Peiyu Han, Hongmin Yin, Zi Yang, Yichen Kong, Bo Wang, Xinglou Yang, Tilian Ren, Yunzhi Zhang   +9 more
doaj   +1 more source

Evidence of orthohantavirus and leptospira infections in small mammals in an endemic area of Gampaha district in Sri Lanka

One Health Outlook, 2022
Background Orthohantaviruses and leptospira are emerging zoonotic pathogens of high public health significance. The epidemiology of orthohantavirus infections and leptospirosis is similar and presents related clinical pictures in humans.
N. P. Sunil-Chandra, Åsa Fahlman, Shantha Waidyarathna, Jonas Näslund, M. V. M. L. Jayasundara, Lwande Olivia Wesula, Göran Bucht   +6 more
doaj   +1 more source

Continuing Orthohantavirus Circulation in Deer Mice in Western Montana [PDF]

Viruses, 2021
Hantavirus pulmonary syndrome (HPS) is an often-fatal disease caused by New World hantaviruses, such as Sin Nombre orthohantavirus (SNV). In the US, >800 cases of HPS have been confirmed since it was first discovered in 1993, of which 43 were reported from the state of Montana.
Brandi N. Williamson, Kimberly Meade-White, Kristin Boardman, Jonathan E. Schulz, Carson T. Telford, Dania M. Figueroa Acosta, Trenton Bushmaker, Robert J. Fischer, Kyle Rosenke, Heinz Feldmann   +9 more
openaire   +3 more sources