Results 31 to 40 of about 7,427 (161)

Increased Heparanase Levels in Urine during Acute Puumala Orthohantavirus Infection Are Associated with Disease Severity

Viruses, 2022
Old–world orthohantaviruses cause hemorrhagic fever with renal syndrome (HFRS), characterized by acute kidney injury (AKI) with transient proteinuria. It seems plausible that proteinuria during acute HFRS is mediated by the disruption of the glomerular ...
Luz E. Cabrera, Constanze Schmotz, Moin A. Saleem, Sanna Lehtonen, Olli Vapalahti, Antti Vaheri, Satu Mäkelä, Jukka Mustonen, Tomas Strandin   +8 more
doaj   +1 more source

Achievement and Challenges in Orthohantavirus Vaccines. [PDF]

Vaccines (Basel)
Orthohantaviruses (also known as hantaviruses) are pathogens that cause two distinct, yet related forms of severe human disease: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). These diseases pose a significant threat to global public health due to their high case fatality rates, which can range from 1% to 50%.
Chai S, Wang L, Du H, Jiang H.
europepmc   +4 more sources

First Molecular Evidence of Seewis Virus in Croatia

Life, 2023
Orthohantaviruses are mainly carried and transmitted by wild rodents, although during the last decade, they have also been identified in multiple species of shrews and moles.
Petra Svoboda Karić, Barbara Anđelić Dmitrović, Stella Mrmić, Antonia Paić, Linda Bjedov, Zrinka Štritof, Josip Margaletić, Ivan-Christian Kurolt   +7 more
doaj   +1 more source

Isolation and Genetic Characterization of Puumala Orthohantavirus Strains from France [PDF]

Pathogens, 2021
Puumala orthohantavirus (PUUV) causes a mild form of haemorrhagic fever with renal syndrome (HFRS) called nephropathia epidemica (NE), regularly diagnosed in Europe. France represents the western frontier of the expansion of NE in Europe with two distinct areas: an endemic area (north-eastern France) where PUUV circulates in rodent populations, with ...
Johann Vulin, Séverine Murri, Sarah Madrières, Maxime Galan, Caroline Tatard, Sylvain Piry, Gabriele Vaccari, Claudia D’Agostino, Nathalie Charbonnel, Guillaume Castel, Philippe Marianneau   +10 more
openaire   +5 more sources

Cytokine Profiles and Antibody Response Associated to Choclo Orthohantavirus Infection [PDF]

Frontiers in Immunology, 2021
BackgroundNew World Hantaviruses (NWHs) are the etiological agent underlying hantavirus cardiopulmonary syndrome (HCPS), a severe respiratory disease with high mortality rates in humans. In Panama, infections with Choclo Orthohantavirus (CHOV) cause a much milder illness characterized by higher seroprevalence and lower mortality rates.
Tybbysay P. Salinas, Tybbysay P. Salinas, Jose L. Garrido, Jose L. Garrido, Jacqueline R. Salazar, Publio Gonzalez, Nicole Zambrano, Francisco Fuentes-Villalobos, Felipe Bravo, Felipe Bravo, Victor Fica-Leon, Alexis Salas-Burgos, Mario Calvo, Raymond Alvarez, Blas Armien, Blas Armien, Maria Ines Barria   +16 more
openaire   +3 more sources

Data-driven models for replication kinetics of Orthohantavirus infections

Mathematical Biosciences, 2022
The Hantaviridae constitute a family of viruses harbored by mice, rats, shrews, voles, moles and bats. Intriguingly, only viruses harbored by mice and rats may cause disease in humans with up to 40% case fatality rate in the Americas. Transmission of virus from rodents to humans occurs via the respiratory route and results in replication of the virus ...
Adams, Alison, Murphy, Quiyana M., Dougherty, Owen P., Sawyer, Aubrey M., Bai, Fan, Edholm, Christina J., Williams, Evan P., Allen, Linda J. S., Jonsson, Colleen B.   +8 more
openaire   +3 more sources

Longitudinal Assessment of Cytokine Expression and Plasminogen Activation in Hantavirus Cardiopulmonary Syndrome Reveals Immune Regulatory Dysfunction in End-Stage Disease

Viruses, 2021
Pathogenic New World orthohantaviruses cause hantavirus cardiopulmonary syndrome (HCPS), a severe immunopathogenic disease in humans manifested by pulmonary edema and respiratory distress, with case fatality rates approaching 40%.
Peter Simons, Yan Guo, Virginie Bondu, Susan L. Tigert, Michelle Harkins, Samuel Goodfellow, Cana Tompkins, Devon Chabot-Richards, Xuexian O. Yang, Laura Gonzalez Bosc, Steven Bradfute, Daniel A. Lawrence, Tione Buranda   +12 more
doaj   +1 more source

Identification and validation of specific B-cell epitopes of hantaviruses associated to hemorrhagic fever and renal syndrome.

PLoS Neglected Tropical Diseases, 2019
BACKGROUND:Orthohantavirus infection is a neglected global health problem affecting approximately 200,000 people/year, spread by rodent hosts and associated to fatal human diseases, such as hemorrhagic fever with renal syndrome (HFRS) and orthohantavirus
Fernando de Paiva Conte, Bianca Corrêa Tinoco, Thiago Santos Chaves, Renata Carvalho de Oliveira, Janaina Figueira Mansur, Ronaldo Mohana-Borges, Elba Regina Sampaio de Lemos, Patricia Cristina da Costa Neves, Rodrigo Nunes Rodrigues-da-Silva   +8 more
doaj   +1 more source

First Evidence of Akodon-Borne Orthohantavirus in Northeastern Argentina

EcoHealth, 2021
Orthohantaviruses (genus Orthohantavirus, family Hantaviridae) are the etiologic agents of Hantavirus Pulmonary Syndrome in the Americas. In South America, orthohantaviruses are highly diverse and are hosted by sigmodontine rodents (subfamiliy Sigmodontinae, family Cricetidae), an also diverse group of rodents.
Burgos, Eliana Florencia, Vadell, María Victoria, Bellomo, Carla María, Martinez, Valeria Paula, Salomón, Oscar Daniel, Gomez Villafañe, Isabel Elisa   +5 more
openaire   +3 more sources

Seoul Orthohantavirus in Wild Black Rats, Senegal, 2012–2013 [PDF]

Emerging Infectious Diseases, 2020
Hantaviruses cause hemorrhagic fever in humans worldwide. However, few hantavirus surveillance campaigns occur in Africa. We detected Seoul orthohantavirus in black rats in Senegal, although we did not find serologic evidence of this disease in humans. These findings highlight the need for increased surveillance of hantaviruses in this region.
Diagne, Moussa, Dieng, Idrissa, Granjon, Laurent, Lucaccioni, Héloïse, Sow, Abdourahmane, Ndiaye, Oumar, Faye, Martin, Bâ, Khalilou, Bâ, Yamar, Diallo, Mamoudou, Faye, Oumar, Duplantier, Jean-Marc, Diallo, Mawlouth, Handschumacher, Pascal, Faye, Ousmane, Sall, Amadou   +15 more
openaire   +6 more sources