Results 11 to 20 of about 3,847 (223)

In silico design and evaluation of a multiepitope vaccine targeting the nucleoprotein of Puumala orthohantavirus [PDF]

Proteins: Structure, Function, and Bioinformatics, Volume 92, Issue 10, Page 1161-1176, October 2024.
The Puumala orthohantavirus is present in the body of the bank vole (Myodes glareolus). Humans infected with this virus may develop hemorrhagic fever accompanying renal syndrome.
Kunal Bhattacharya, Nongmaithem Randhoni Chanu, S. Jha, P. Khanal, K. Paudel   +4 more
semanticscholar   +3 more sources

Phylogenetic Characterization of Orthohantavirus dobravaense (Dobrava Virus). [PDF]

Emerg Infect Dis
We report complete coding sequences of Orthohantavirus dobravaense (Dobrava virus) Igneada strains and phylogenetic characterization of all available complete coding sequences.
Erdin M, Polat C, Smura T, Irmak S, Cetintas O, Cogal M, Colak F, Karatas A, Sozen M, Matur F, Vapalahti O, Sironen T, Oktem IMA.   +12 more
europepmc   +8 more sources

Small mammal community composition impacts bank vole (Clethrionomys glareolus) population dynamics and associated seroprevalence of Puumala orthohantavirus [PDF]

Integrative Zoology, Volume 19, Issue 1, Page 52-65, January 2024., 2023
Rodents are important reservoirs for zoonotic pathogens that cause diseases in humans. Biodiversity is hypothesized to be closely related to pathogen prevalence through multiple direct and indirect pathways.
Bujnoch, Felicitas Maria, Drewes, Stephan, Imholt, Christian, Jacob, Jens, Reil, Daniela, Rosenfeld, Ulrike M., Ulrich, Rainer G.   +6 more
core   +3 more sources

Phylogeography of Puumala orthohantavirus in Europe [PDF]

Viruses, 2019
Puumala virus is an RNA virus hosted by the bank vole (Myodes glareolus) and is today present in most European countries. Whilst it is generally accepted that hantaviruses have been tightly co-evolving with their hosts, Puumala virus (PUUV) evolutionary ...
Castel, Guillaume, Chevenet, François, Cosson, Jean-François, Marianneau, Philippe, Murri, Séverine, Plyusnin, Alexander, Razzauti, Maria, Tordo, Noël   +7 more
core   +17 more sources

Clinical and etiological characteristics of severe hemorrhagic fever caused by coinfection of hantaan orthohantavirus and severe fever with thrombocytopenia syndrome virus

Journal of Medical Virology, Volume 96, Issue 9, September 2024.
Severe fever with thrombocytopenia syndrome (SFTS) and hemorrhagic fever with renal syndrome (HFRS) usually have different infection routes, and coinfection is relatively rare.
Fenghua Jiang, Yongxiang Zhao, Ruihao Peng, Ya Wen, Yudan Bi, Yichen Zhou, Yao Chen, Hua Deng, Xiaohu Han, Zeliang Chen   +9 more
semanticscholar   +3 more sources

Isolation and characterization of new Puumala orthohantavirus strains from Germany [PDF]

Virus Genes, 2020
Orthohantaviruses are re-emerging rodent-borne pathogens distributed all over the world. Here, we report the isolation of a Puumala orthohantavirus (PUUV) strain from bank voles caught in a highly endemic region around the city Osnabrück, north-west ...
Binder, Florian, Höper, Dirk, Kunec, Dusan, Reiche, Sven, Roman-Sosa, Gleyder, Ryll, René, Saathoff, Marion, Trimpert, Jakob, Ulrich, Rainer G.   +8 more
core   +10 more sources

Achievement and Challenges in Orthohantavirus Vaccines. [PDF]

Vaccines (Basel)
Orthohantaviruses (also known as hantaviruses) are pathogens that cause two distinct, yet related forms of severe human disease: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). These diseases pose a significant threat to global public health due to their high case fatality rates, which can range from 1% to 50%.
Chai S, Wang L, Du H, Jiang H.
europepmc   +5 more sources

Unraveling the Mechanistic Links Between Species Diversity and Infection Risk From Zoonotic Pathogens With Direct Transmission Among Reservoir Hosts: Rodent-Orthohantavirus Systems as Models. [PDF]

Ecol Evol
In this review, we synthesize mechanistic evidence for diversity‐disease patterns in rodent‐orthohantavirus systems in the Americas, models of directly transmitted disease systems. We found that host regulation has been examined the most while other mechanisms have received less attention. Based on our findings, we propose that for a negative diversity‐
Eleftheriou A, Luis AD.
europepmc   +3 more sources

The Immune Correlates of Orthohantavirus Vaccine [PDF]

Vaccines, 2021
Zoonotic transmission of orthohantaviruses from rodent reservoirs to humans has been the cause of severe fatalities. Human infections are reported worldwide, but vaccines have been approved only in China and Korea. Orthohantavirus vaccine development has
Joon-Yong Bae, Jin Il Kim, Mee Sook Park, Gee Eun Lee, Heedo Park, Ki-Joon Song, Man-Seong Park   +6 more
doaj   +3 more sources

Maturing neutrophils of lower density associate with thrombocytopenia in Puumala orthohantavirus-caused hemorrhagic fever with renal syndrome [PDF]

bioRxiv
Puumala orthohantavirus-caused hemorrhagic fever with renal syndrome (PUUV-HFRS) is characterized by strong neutrophil activation. Neutrophils are the most abundant immune cell type in the circulation and are specially equipped to rapidly respond to ...
Luz E. Cabrera, J. Tietäväinen, S. Jokiranta, S. Mäkelä, Antti Vaheri, J. Mustonen, Olli Vapalahti, M. Kanerva, T. Strandin   +8 more
semanticscholar   +2 more sources