Results 11 to 20 of about 8,386 (211)

Achievement and Challenges in Orthohantavirus Vaccines [PDF]

Vaccines
Orthohantaviruses (also known as hantaviruses) are pathogens that cause two distinct, yet related forms of severe human disease: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS).
Shiqi Chai, Limei Wang, Hong Du, Hong Jiang   +3 more
doaj   +4 more sources

The Immune Correlates of Orthohantavirus Vaccine [PDF]

Vaccines, 2021
Zoonotic transmission of orthohantaviruses from rodent reservoirs to humans has been the cause of severe fatalities. Human infections are reported worldwide, but vaccines have been approved only in China and Korea. Orthohantavirus vaccine development has
Joon-Yong Bae, Jin Il Kim, Mee Sook Park, Gee Eun Lee, Heedo Park, Ki-Joon Song, Man-Seong Park   +6 more
doaj   +3 more sources

Hypopituitarism after Orthohantavirus Infection: What is Currently Known? [PDF]

Viruses, 2019
Several case reports have described hypopituitarism following orthohantavirus infection, mostly following Puumala virus. The pathogenesis of this seemingly rare complication of orthohantavirus infection remains unknown.
Soerajja Bhoelan, Thomas Langerak, Danny Noack, Linda van Schinkel, Els van Nood, Eric C.M. van Gorp, Barry Rockx, Marco Goeijenbier   +7 more
doaj   +3 more sources

Orthohantavirus Pathogenesis and Cell Tropism [PDF]

Frontiers in Cellular and Infection Microbiology, 2020
Orthohantaviruses are zoonotic viruses that are naturally maintained by persistent infection in specific reservoir species. Although these viruses mainly circulate among rodents worldwide, spill-over infection to humans occurs.
Danny Noack, Marco Goeijenbier, Marco Goeijenbier, Chantal B. E. M. Reusken, Chantal B. E. M. Reusken, Marion P. G. Koopmans, Barry H. G. Rockx   +6 more
doaj   +6 more sources

Development of a Comparative European Orthohantavirus Microneutralization Assay With Multi- Species Validation and Evaluation in a Human Diagnostic Cohort

Frontiers in Cellular and Infection Microbiology, 2020
Orthohantaviruses (family Hantaviridae, order Bunyavirales) can cause two serious syndromes in humans: hemorrhagic fever with renal syndrome (HFRS), associated with the Old World orthohantaviruses, and hantavirus cardiopulmonary syndrome (HCPS ...
Tabitha E. Hoornweg, Ilse Zutt, Ankje de Vries, Miriam Maas, Marieke N. Hoogerwerf, Tatjana Avšič-Županc, Miša Korva, Johan H. J. Reimerink, Chantal B. E. M. Reusken   +8 more
doaj   +2 more sources

Interactions Between Hantavirus Nucleoprotein and Glycoproteins: A Quantitative Fluorescence Microscopy Study [PDF]

Viruses
Orthohantaviruses are tri-segmented negative-sense RNA viruses that can cause severe pathologies in humans. Currently, limited information exists on the molecular interactions driving orthohantavirus assembly in infected cells.
Amit Koikkarah Aji, Titas Mandal, Salvatore Chiantia   +2 more
doaj   +2 more sources

Pathogenicity and virulence of Rodent-Borne Orthohantaviruses [PDF]

Virulence
The Orthohantavirus genus in the family Hantaviridae includes viruses that cause zoonotic diseases in humans known as hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). Exposure of humans to these viruses occurs through
Shannon L. Taylor, Connie S. Schmaljohn, Evan P. Williams, Colleen B. Jonsson   +3 more
doaj   +2 more sources

Novel Orthohantavirus Associated with Hantavirus Pulmonary Syndrome in Northern Argentina [PDF]

Viruses
In this work, we performed the genetic characterization of a new variant of orthohantavirus associated with a fatal case of hantavirus pulmonary syndrome, outside the known endemic region, in northwestern Argentina.
Carla M. Bellomo, Sebastian Kehl, Daniel Oscar Alonso, Walter López, Flavia Cassinelli, Rocío María Coelho, Gabriela Bravo, Sara Aguirre, Marcela Dib, Natalia Periolo, Concepción Toscano, José Gil, Francisco García Campos, Ignacio Ferro, Valeria Paula Martinez   +14 more
doaj   +2 more sources

Orthohantavirus Spp. – Review Of Genus [PDF]

Postępy Mikrobiologii - Advancements of Microbiology, 2021
Abstract The infections caused by orthohantaviruses were already known in the Middle Ages as “English sweats.” There are two main diseases caused by these viruses – HPS (hantavirus pulmonary syndrome) and HFRS (hemorrhagic fever with renal syndrome). Rodents are the main reservoir of these microorganisms, and humans usually catch them
Kamil Leis, Patryk Kaczor, Aleksandra Baska, Jakub Kazik, Michalina Kolan, Katarzyna Grudlewska‐Buda, Natalia Wiktorczyk-Kapischke, Krzysztof Skowron   +7 more
openalex   +4 more sources

Use of a diagnostic Puumala virus real-time RT-PCR in an orthohantavirus endemic region in the Netherlands [PDF]

Microbiology Spectrum
Laboratory diagnosis of orthohantavirus infection is primarily based on serology. However, for a confirmed serological diagnosis, evaluation of a follow-up serum sample is essential, which is time consuming and causes delay.
Felix Geeraedts, Mariska Wevers, Froukje Bosma, Maria de Boer, J. N. Brinkman, Corine Delsing, Corine GeurtsvanKessel, Barry Rockx, Adri van der Zanden, Gozewijn D. Laverman   +9 more
doaj   +2 more sources