Species-specific responses during Seoul orthohantavirus infection in human and rat lung microvascular endothelial cells [PDF]
Seoul orthohantavirus (SEOV) is a rat-borne zoonotic virus that is transmitted via inhalation of aerosolized infectious excreta, and can cause hemorrhagic fever with renal syndrome (HFRS) in humans worldwide.
Embregts, Carmen W.E.+5 more
core +2 more sources
Orthohantavirus Replication in the Context of Innate Immunity
Orthohantaviruses are rodent-borne, negative-sense RNA viruses that are capable of causing severe vascular disease in humans. Over the course of viral evolution, these viruses have tailored their replication cycles in such a way as to avoid and/or ...
Autumn LaPointe+2 more
doaj +3 more sources
Detection of divergent Orthohantavirus tulaense provides insight into wide host range and viral evolutionary patterns. [PDF]
Orthohantavirus tulaense (TULV) is a member of the orthohantavirus genus and distributed in Europe and Asia. To shed light on TULV epidemiology and evolution, we trapped wild rodents from eastern Turkiye and found 15 TULV positive rodents. Sequencing and
Erdin M+10 more
europepmc +2 more sources
Interactions Between Hantavirus Nucleoprotein and Glycoproteins: A Quantitative Fluorescence Microscopy Study [PDF]
Orthohantaviruses are tri-segmented negative-sense RNA viruses that can cause severe pathologies in humans. Currently, limited information exists on the molecular interactions driving orthohantavirus assembly in infected cells.
Amit Koikkarah Aji+2 more
doaj +2 more sources
Development of a Comparative European Orthohantavirus Microneutralization Assay With Multi- Species Validation and Evaluation in a Human Diagnostic Cohort [PDF]
Orthohantaviruses (family Hantaviridae, order Bunyavirales) can cause two serious syndromes in humans: hemorrhagic fever with renal syndrome (HFRS), associated with the Old World orthohantaviruses, and hantavirus cardiopulmonary syndrome (HCPS ...
Tabitha E. Hoornweg+8 more
doaj +2 more sources
First Evidence of Akodon-Borne Orthohantavirus in Northeastern Argentina [PDF]
Orthohantaviruses (genus Orthohantavirus, family Hantaviridae) are the etiologic agents of Hantavirus Pulmonary Syndrome in the Americas. In South America, orthohantaviruses are highly diverse and are hosted by sigmodontine rodents (subfamiliy ...
Bellomo, Carla María+5 more
core +4 more sources
Hypopituitarism after Orthohantavirus Infection: What is Currently Known? [PDF]
Several case reports have described hypopituitarism following orthohantavirus infection, mostly following Puumala virus. The pathogenesis of this seemingly rare complication of orthohantavirus infection remains unknown.
Soerajja Bhoelan+7 more
doaj +4 more sources
INTRODUCTION Hemorrhagic fever with renal syndrome (HFRS) is the most common zoonotic human viral disease in the Russian Federation. More than 98% of the HFRS cases are caused by Puumala orthohantavirus (PUU). Effective serological tests are required for
Alexander P. Ivanov+5 more
semanticscholar +2 more sources
Orthohantavirus Spp. – Review Of Genus [PDF]
The infections caused by orthohantaviruses were already known in the Middle Ages as “English sweats.” There are two main diseases caused by these viruses – HPS (hantavirus pulmonary syndrome) and HFRS (hemorrhagic fever with renal syndrome).
Leis Kamil+7 more
doaj +3 more sources
Orthohantavirus Pathogenesis and Cell Tropism [PDF]
Orthohantaviruses are zoonotic viruses that are naturally maintained by persistent infection in specific reservoir species. Although these viruses mainly circulate among rodents worldwide, spill-over infection to humans occurs.
Danny Noack+6 more
doaj +4 more sources