Results 61 to 70 of about 7,448 (158)

Unraveling the Mechanistic Links Between Species Diversity and Infection Risk From Zoonotic Pathogens With Direct Transmission Among Reservoir Hosts: Rodent‐Orthohantavirus Systems as Models

Ecology and Evolution, Volume 15, Issue 6, June 2025.
In this review, we synthesize mechanistic evidence for diversity‐disease patterns in rodent‐orthohantavirus systems in the Americas, models of directly transmitted disease systems. We found that host regulation has been examined the most while other mechanisms have received less attention. Based on our findings, we propose that for a negative diversity‐
Andreas Eleftheriou, Angela D. Luis
wiley   +1 more source

Delayed viral clearance despite high number of activated T cells during the acute phase in Argentinean patients with hantavirus pulmonary syndrome

EBioMedicine, 2022
Summary: Background: The hallmarks of HPS are increase of vascular permeability and endothelial dysfunction. Although an exacerbated immune response is thought to be implicated in pathogenesis, clear evidence is still elusive.
Ayelén Aluminé Iglesias, Natalia Períolo, Carla María Bellomo, Lorena Cecilia Lewis, Camila Paula Olivera, Constanza Rosario Anselmo, Marina García, Rocío María Coelho, Daniel Oscar Alonso, Bonnie Dighero-Kemp, Heema Sharma, Jens H. Kuhn, Nicholas Di Paola, Mariano Sanchez-Lockhart, Gustavo Palacios, Luis Pablo Schierloh, Valeria Paula Martínez   +16 more
doaj   +1 more source

Climate Change‐Driven Heatwaves Pose Lethal Risks to Newborn Forest Bats

Ecology and Evolution, Volume 15, Issue 5, May 2025.
This is the first recorded case of forest bat mortality in temperate regions caused by heatwaves. The study suggests that forest fragmentation exposes bats to lethal thermal peaks, highlighting a previously overlooked impact of climate change on these mammals and potential interactions with forest fragmentation.
Danilo Russo, Anne Mäenurm, Luca Cistrone, Adriano Martinoli, Greta Foiani, Valentina Giongo, Stefania Leopardi   +6 more
wiley   +1 more source

Phylogenetic Characterization of Orthohantavirus dobravaense (Dobrava Virus)

Emerging Infectious Diseases
We report complete coding sequences of Orthohantavirus dobravaense (Dobrava virus) Igneada strains and phylogenetic characterization of all available complete coding sequences. Our analyses suggested separation of host-dependent lineages, followed by geographic clustering.
Erdin, Mert, Polat, Ceylan, Smura, Teemu, Irmak, Sercan, Cetintas, Ortac, Cogal, Muhsin, Colak, Faruk, Karatas, Ahmet, Sozen, Mustafa, Matur, Ferhat, Vapalahti, Olli, Sironen, Tarja, Oktem, Ibrahim Mehmet Ali   +12 more
openaire   +6 more sources

Effect of Land‐Use on Hantavirus Infection Among Introduced and Endemic Small Mammals of Madagascar

Ecology and Evolution, Volume 15, Issue 4, April 2025.
Addressing the risk of Hantavirus spillover from animal reservoirs to humans requires identifying the local reservoirs and the predictors of infection. We screened a collection of 1880 small mammals for Hantavirus RNA from northeastern Madagascar, and specifically investigated the influence of diverse natural or anthropized habitats as well as animal ...
Jérémy Dubrulle, Kayla Kauffman, Voahangy Soarimalala, Toky Randriamoria, Steven M. Goodman, James Herrera, Charles Nunn, Pablo Tortosa   +7 more
wiley   +1 more source

THE DYNAMICS OF ORTHOHANTAVIRUS HANTAAN STRAINS REPLICATION ON THE MODEL OF MOUSE PERITONEAL MACROPHAGES

Acta Biomedica Scientifica, 2018
Orthohantaviruses (Orthohantavirus genus, Hantaviridae family) are the causative agents of a widespread natural focal infection in the  Russian Federation, hemorrhagic fever with renal syndrome (HFRS).
A. B. Pott, O. V. Iunikhina, I. N. Lyapun, G. G. Kompanets   +3 more
doaj   +1 more source

Hantavirus in rodents in the United States: Temporal and spatial trends and report of new hosts

Ecosphere, Volume 16, Issue 3, March 2025.
Abstract In North America, the rodent‐borne hantavirus pulmonary syndrome is predominantly caused by the Sin Nombre virus, typically associated with the deer mouse Peromyscus maniculatus. Utilizing data from the National Ecological Observatory Network (NEON) hantavirus program, we assessed factors that may influence the spatial and temporal ...
Francisca Astorga, Abdelghafar Alkishe, Paanwaris Paansri, Gabriel Mantilla, Luis E. Escobar   +4 more
wiley   +1 more source

Quantification and kinetics of viral RNA transcripts produced in Orthohantavirus infected cells

Virology Journal, 2018
Background Rodent borne viruses of the Orthohantavirus genus cause hemorrhagic fever with renal syndrome among people in Eurasia, and hantavirus cardiopulmonary syndrome in the Americas.
Julia Wigren Byström, Jonas Näslund, Fredrik Trulsson, Magnus Evander, Olivia Wesula Lwande, Clas Ahlm, Göran Bucht   +6 more
doaj   +1 more source

Hantaan virus glycoprotein Gc induces NEDD4‐dependent PTEN ubiquitination and degradation to escape the restriction of autophagosomes and facilitate viral propagation

The FASEB Journal, Volume 39, Issue 1, 15 January 2025.
The proposed model of HTNV induced PTEN degradation and PTEN‐regulated autophagy in progeny virus production: In HTNV‐infected HK‐2 cells, the viral Gc glycoprotein specifically promotes NEDD4 mediated ubiquitination and degradation of PTEN. Disruption of PTEN expression prevents autophagosome formation and increases HTNV production, whereas ...
Shuang Lu, Shuliang Chen, Yuqing Zhang, Xiaoli Mou, Mingyang Li, Shaowei Zhu, Xingyuan Chen, Tomas M. Strandin, Yale Jiang, Zhoufu Xiang, Yuanyuan Liu, Hairong Xiong, Deyin Guo, Liangjun Chen, Yirong Li, Wei Hou, Fan Luo   +16 more
wiley   +1 more source

Report of a novel pathogenic orthohantavirus in Tucuman, Argentina

Revista Argentina de Microbiología
The confirmation of two cases of hantavirus pulmonary syndrome (HPS) in the city of San Miguel de Tucuman, province of Tucuman, is described in the present study. In 2021, the diagnosis of two patients with HPS with no history of travel outside the province was confirmed. The infection was determined by serology in both cases. Case 1 had an unfavorable
Julia Brignone, Carina Sen, María Laura Martin, Natalia Fernandez, Gabriela Delgado, Anabel Sinchi, Yael Nazar, María Cecilia Monzani, María Laura Cisneros, Patricia Clua, Rocío Coronel, Jorge García   +11 more
openaire   +2 more sources