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Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress

Cell Stem Cell
Stem cells are known for their resilience and enhanced activity post-stress. The mammary gland undergoes frequent remodeling and is subjected to recurring stress during the estrus cycle, but it remains unclear how mammary stem cells (MaSCs) respond to the stress and contribute to regeneration.
Liu, Chunye   +8 more
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Periodic Signaling and Receptor Desensitization: From cAMP Oscillations in Dictyostelium Cells to Pulsatile Patterns of Hormone Secretion

1987
Why are so many hormones released in a rhythmic, pulsatile manner? Since KNOBIL and co-workers (1,2) demonstrated that pulsatile stimulation by the hypothalamic hormone GnRH at regular, physiological intervals elicits the release of the gonadotropins LH and FSH by the pituitary — whereas continuous signaling by GnRH fails to yield such response —, an ...
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