Results 71 to 80 of about 42,609 (234)

Network medicine and systems pharmacology approaches to predicting adverse drug effects

British Journal of Pharmacology, Volume 183, Issue 8, Page 1627-1639, April 2026.
Identifying and understanding the relationships between drug intake and adverse effects that can occur due to inadvertent molecular interactions between drugs and targets is a difficult task, especially considering the numerous variables that can influence the onset of such events.
Alessio Funari, Giulia Fiscon, Paola Paci   +2 more
wiley   +1 more source

In response [PDF]

, 1993
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Cowling, BJ, Lau, EHY, Leung, GM
core   +7 more sources

Role of therapeutic drug monitoring in pulmonary infections : use and potential for expanded use of dried blood spot samples [PDF]

, 2015
Respiratory tract infections are among the most common infections in men. We reviewed literature to document their pharmacological treatments, and the extent to which therapeutic drug monitoring (TDM) is needed during treatment.
Akkerman, Onno W, Alffenaar, Jan-Willem C, Bolhuis, Mathieu S, Hofman, Susan, Koster, Remco A, Stove, Christophe, van Assen, Sander   +6 more
core   +5 more sources

Detection of H275Y Mutation Conferring Oseltamivir Drug Resistance in Influenza A (H1N1) pdm09 Virus

Journal of Pure and Applied Microbiology, 2021
In the treatment of influenza, Neuraminidase inhibitors (NAIs) (Oseltamivir and Zanamivir) play a major role. The emergence of variants of influenza A (H1N1) pdm09 virus resistant to Oseltamivir is a matter of great concern as it limits its usage ...
Khushbu Trivedi, Bharti Malhotra, Widhi Dubey, Pratibha Sharma, Farah Deeba, Jitendra Tiwari, Aradhana Chauhan   +6 more
doaj   +1 more source

First sequence-confirmed case of infection with the new influenza A(H1N1) strain in Germany [PDF]

, 2009
Here, we report on the first sequence-confirmed case of infection with the new influenza A(H1N1) virus in Germany. Two direct contacts of the patient were laboratory-confirmed as cases and demonstrate a chain of direct human-to-human ...
Feierabend, K., Jilg, W., Kochanowski, B., Kreuzpaintner, B., Kreuzpaintner, E., Melzl, H., Niller, H. H., Reischl, U., Rohrhofer, A., Salzberger, B., Schreder-Meindl, S., Wenzel, J. J., Wolf, H., Wollner, H.   +13 more
core   +1 more source

Development of a C5‐Azidoacetamide‐Modified 4‐Amino‐2,3‐Difluorosialic Acid Activity‐Based Probe for Labeling of Influenza A Neuraminidases

ChemBioChem, Volume 27, Issue 6, 27 March 2026.
We report DFSA5Az/DFSA5bio, C5‐azidoacetamide 4‐amino‐2,3‐difluorosialic acid activity‐based probes that trap influenza A viral (IAV) neuraminidases (NA) via a stabilized covalent Tyr‐sialosyl intermediate with hour‐scale reactivation. A bioorthogonal azide enables CuAAC (or one‐step biotin) tagging for activity‐dependent Western‐blot detection at ...
Lemeng Chao, Erianna I. Alvarado‐Melendez, Katherine Marougka, Xuesheng Wu, Cornelis A. M. de Haan, Karin Strijbis, Tom Wennekes   +6 more
wiley   +1 more source

Characteristics of Fatal Cases of Pandemic Influenza A (H1N1) from September 2009 to January 2010 in Saurashtra Region, India [PDF]

, 2011
Background: India reported first case of 2009 pandemic influenza A (H1N1) virus infection in May, 2009 and Saurashtra region in August, 2009. We describe the characteristics of fatal cases of 2009 influenza A (H1N1) infection reported in Saurashtra ...
Amin, Chikitsa D, Banerjee, Anupam, Chudasama, Rajesh K, Patel, Ravikant R, Patel, Umed V, Shah, Hitesh M, Verma, Pramod B   +6 more
core   +1 more source

Inhibitory activity of selenium nanoparticles functionalized with oseltamivir on H1N1 influenza virus

International Journal of Nanomedicine, 2017
As an effective antiviral agent, the clinical application of oseltamivir (OTV) is limited by the appearance of drug-resistant viruses. Due to their low toxicity and excellent activity, the antiviral capabilities of selenium nanoparticles (SeNPs) has ...
Yinghua Li, Zhengfang Lin, M. Guo, Yu Xia, Mingqi Zhao, Chang-bing Wang, Tiantian Xu, Tianfeng Chen, B. Zhu   +8 more
semanticscholar   +1 more source

Quinic Acid and Synthetic Derivatives in Medicinal Chemistry

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
Quinic acid and its derivatives are gaining recognition as versatile scaffolds in drug discovery. This review explores their emerging roles in inflammation, infection, cancer, and metabolic disorders, highlighting recent advances that position them beyond chlorogenic acids as promising platforms for therapeutic innovation. Quinic acid (QA) is a natural
Iago C. Vogel, Manuel J. Verganista, Nuno R. Candeias   +2 more
wiley   +1 more source

Rational design of a deuterium-containing M2-S31N channel blocker UAWJ280 with in vivo antiviral efficacy against both oseltamivir sensitive and -resistant influenza A viruses

Emerging Microbes and Infections, 2021
Seasonal influenza A virus (IAV) infections are among the most important global health problems. FDA-approved antiviral therapies against IAV include neuraminidase inhibitors, M2 inhibitors, and polymerase inhibitor baloxavir.
C. Joaquín Cáceres, Yanmei Hu, Stivalis Cárdenas-García, Xiangmeng Wu, Haozhou Tan, Silvia Carnaccini, L. Claire Gay, Ginger Geiger, Chunlong Ma, Qing-Yu Zhang, Daniela Rajao, Daniel R. Perez, Jun Wang   +12 more
doaj   +1 more source