Results 61 to 70 of about 34,354 (193)

A Novel Molecularly Imprinted Electrochemiluminescence Sensor Based on Mxene Quantum Dots for Selective Detection of Oseltamivir in Biological Samples

Molecules
Oseltamivir is a drug that has been widely used to prevent and treat influenza A and B. In this work, an ultrasensitive, simple, and novel electrochemiluminescence (ECL) sensor combined with molecularly imprinted polymers (MIP-ECL) based on a graphene ...
Wei Guo, Shiqiang Yan, Chaoqiang Xiao, Dayong Shi, Qing Hua, Xiaowen Hao, Wenjuan Zhang, Xuming Zhuang   +7 more
doaj   +1 more source

Detection of H275Y Mutation Conferring Oseltamivir Drug Resistance in Influenza A (H1N1) pdm09 Virus

Journal of Pure and Applied Microbiology, 2021
In the treatment of influenza, Neuraminidase inhibitors (NAIs) (Oseltamivir and Zanamivir) play a major role. The emergence of variants of influenza A (H1N1) pdm09 virus resistant to Oseltamivir is a matter of great concern as it limits its usage ...
Khushbu Trivedi, Bharti Malhotra, Widhi Dubey, Pratibha Sharma, Farah Deeba, Jitendra Tiwari, Aradhana Chauhan   +6 more
doaj   +1 more source

Clinical application of a modified platelet desialylation test for mechanistic characterization of platelet transfusion refractoriness

Transfusion, EarlyView.
Abstract Background Platelet transfusion refractoriness (PTR) is a major challenge in transfusion medicine and may result from both immune and non‐immune mechanisms. Although alloantibodies are well‐established contributors, Fc‐independent pathways such as platelet desialylation have emerged as alternative mechanisms of clearance.
Karen Ziza, Thamy Silva, Mateus Domentino, Marina Conrado, João Oliveira, Elyse Moritz, Akemi Chiba, Vanderson Rocha, Alfredo Mendrone‐Junior, José Bordin, Langhi Dante, Carla Dinardo   +11 more
wiley   +1 more source

Characteristics of Fatal Cases of Pandemic Influenza A (H1N1) from September 2009 to January 2010 in Saurashtra Region, India [PDF]

, 2011
Background: India reported first case of 2009 pandemic influenza A (H1N1) virus infection in May, 2009 and Saurashtra region in August, 2009. We describe the characteristics of fatal cases of 2009 influenza A (H1N1) infection reported in Saurashtra ...
Amin, Chikitsa D, Banerjee, Anupam, Chudasama, Rajesh K, Patel, Ravikant R, Patel, Umed V, Shah, Hitesh M, Verma, Pramod B   +6 more
core   +1 more source

Physiological and anatomical determinants of placental drug transfer

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis, Anandita Umapathy, Jane K. Cleal, Bram G. Sengers   +3 more
wiley   +1 more source

Influenza and Other Respiratory Virus Weekly Activity Report, March 28, 2009, Week 12 [PDF]

, 2009
Weekly report of the Iowa Influenza Surveillance Network produced by the Iowa Department of Public ...

core  

Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase [PDF]

, 2012
This work was supported by the Medical Research Council and the Scottish Funding Council.Influenza virus sialidase has an essential role in the virus’ life cycle.
Dyason, JC, Kerry, Philip Stephen, Naffakh, N, Rameix-Welti, MA, Rose, FJ, Rudrawar, S, Russell, Rupert James Martin, Thomson, RJ, van der Werf, S, von Itzstein, M   +9 more
core   +1 more source

Organoids: From Bench to Bedside Applications

MedComm, Volume 7, Issue 6, June 2026.
Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li, Rui Cao, Maochen Li, Zichao Tian, Huahao Fan, Bixia Hong, Xiaojuan Liu   +6 more
wiley   +1 more source

Deletions in the neuraminidase stalk region of H2N2 and H9N2 avian influenza virus subtypes do not affect postinfluenza secondary bacterial pneumonia [PDF]

, 2012
We investigated the synergism between influenza virus and Streptococcus pneumoniae, particularly the role of deletions in the stalk region of the neuraminidase (NA) of H2N2 and H9N2 avian influenza viruses.
Chen, Hongjun, Chockalingam, Ashok K., Echenique, Jose Ricardo, Ferrero, Andrea, Hickman, Danielle, Pena, Lindomar, Perez, Daniel R., Sutton, Troy, Ye, Jianqiang   +8 more
core   +1 more source

An Evaluation of Foreign Clinical Data in the Approval Reviews of Antimicrobial Medicines in Japan: Considering Ethnic and Regional Differences in Data Extrapolations in Accordance With Regulatory Circumstances

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT The approval requirements in new regions that do not require domestic clinical data and the clinical data evaluation of multi‐regional clinical trials (MRCTs) and foreign clinical trials (FCTs) in the Japanese approval review processes for antimicrobial medicines were explored.
Rumiko Shimazawa, Masayuki Ikeda
wiley   +1 more source