Results 61 to 70 of about 24,935 (185)

Time Economical Total Synthesis of (−)-Oseltamivir

, 2016
A time economical 60 min total synthesis of (−)-oseltamivir was accomplished in a single reaction vessel over five steps. One of the key issues is reduction in the number of steps by eliminating lengthy reaction steps with substitution of a rapid ...
Shin Ogasawara (1831567), Yujiro Hayashi (467585)   +1 more
core   +1 more source

Net Renal Drug Secretion Critically Requires Significant Contribution of Basal Uptake Transporters: Perspective From Mechanistic Kidney Model Simulation and Integration of Clinical and In Vitro Data

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 9, September 2026.
ABSTRACT Renal clearance (CLr) is the net outcome of glomerular filtration, secretion, and reabsorption, which makes the quantitative requirements for net renal secretion difficult to infer from simple clearance models. Using a mechanistic kidney model (MechKiM), we simulated blood‐referenced CLr (CLr,b) for 30,000 virtual drugs (neutral, monoanionic ...
Toshiaki Tsuchitani, Masatoshi Tomi, Yuichi Sugiyama   +2 more
wiley   +1 more source

Oseltamivir and oseltamivir carboxylate pharmacokinetics in obese adults: dose modification for weight is not necessary.

, 2011
Obesity is an independent risk factor for mortality in patients infected with pandemic influenza A virus (H1N1). Given the poor outcomes observed among adult obese patients with H1N1, the dosing of antiviral agents in this population has been questioned,
Pai, Manjunath P, Lodise, Thomas P
core   +2 more sources

Elevating the importance of Risk of Bias assessment for ecology and evolutionary biology

Methods in Ecology and Evolution, Volume 17, Issue 9, Page 2559-2573, September 2026.
Abstract Systematic reviews and meta‐analyses are key evidence synthesis methods for informing future research, interventions and policy. As the validity of their conclusions depends on the primary studies they synthesise, assessing the internal validity of the included studies is essential.
Antica Culina, Dugald Foster, Matthew Grainger, Rose E. O'Dea, Oliver L. Pescott, Alfredo Sánchez‐Tójar, Robin J. Boyd, Julia Koricheva, Shinichi Nakagawa, Gavin Stewart   +9 more
wiley   +1 more source

Decreased Hospital Length of Stay With Early Administration of Oseltamivir in Patients Hospitalized With Influenza

Mayo Clinic Proceedings: Innovations, Quality & Outcomes, 2020
Objective: To evaluate the effects of timely oseltamivir administration in patients hospitalized with seasonal influenza. Patients and Methods: We performed a single-center retrospective cohort study for hospitalized patients who tested positive for ...
Lin Dou, MD, Dan Reynolds, MD, Lindsey Wallace, MS, PA-C, John O’Horo, MD, MPH, Rahul Kashyap, MBBS, Ognjen Gajic, MD, Hemang Yadav, MBBS   +6 more
doaj   +1 more source

Outcomes of early oseltamivir treatment for hospitalized adult patients with community-acquired influenza pneumonia.

PLoS ONE, 2021
Early initiation of oseltamivir within 48 h to 5 days from illness onset has been associated with improved survival among patients with community-acquired influenza pneumonia.
Narongdet Kositpantawong, Smonrapat Surasombatpattana, Pisud Siripaitoon, Siripen Kanchanasuwan, Thanaporn Hortiwakul, Boonsri Charernmak, Ozioma Forstinus Nwabor, Sarunyou Chusri   +7 more
doaj   +1 more source

From Nucleobases to Bioactive NHC‐Based Gold and Silver Complexes With Anticancer and Antiviral Activity

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Herein, we reported the design and synthesis of a novel series of N‐heterocyclic carbene (NHC) complexes originated from the imidazole ring of guanine and guanosine and with different counterions (iodide, acetate, and aminoacidate). The evaluation of the biological activities, that is anticancer and antiviral, indicated L2AuOAc as the best complex ...
Domenico Iacopetta, Jessica Ceramella, Paola Checconi, Flavio Frezza, Maria Marra, Annaluisa Mariconda, Assunta D’Amato, Alessia Catalano, Stefano Aquaro, Pasquale Longo, Maria Stefania Sinicropi   +10 more
wiley   +1 more source

Neuraminidase inhibitors for influenza: a systematic review and meta-analysis of regulatory and mortality data

Health Technology Assessment, 2016
Background: Neuraminidase inhibitors (NIs) are stockpiled and recommended by public health agencies for treating and preventing seasonal and pandemic influenza. They are used clinically worldwide.
Carl J Heneghan, Igho Onakpoya, Mark A Jones, Peter Doshi, Chris B Del Mar, Rokuro Hama, Matthew J Thompson, Elizabeth A Spencer, Kamal R Mahtani, David Nunan, Jeremy Howick, Tom Jefferson   +11 more
doaj   +1 more source

Synthesis and Glycosidase Inhibition Studies of Novel Exoglycals Targeting GH3 Family Enzymes: Insights from Comparative Analysis with Macrolide Antibiotics

Chemistry – A European Journal, Volume 32, Issue 29, 7 August 2026.
A series of structurally diverse exoglycals was synthesized using a modified Julia‐olefination approach from sugar‐derived precursors. These glycosidase transition‐state mimics were further diversified via CuAAC chemistry to yield triazole‐conjugated analogues.
Elisa Ospanow, Oscar L. Alferez, David L. Jakeman   +2 more
wiley   +1 more source

Equity in the Receipt of Oseltamivir in the United States During the H1N1 Pandemic

, 2014
Objectives. We assessed the relationship between individual characteristics and receipt of oseltamivir (Tamiflu) in the United States during the H1N1 pandemic and other flu seasons. Methods. In a cohort of individuals enrolled in pharmacy benefit plans,
Fischer, Michael, Matlin, Olga S., Choudhry, Niteesh, Uscher-Pines, Lori, Avorn, Jerome, Brill, Gregory, Schneeweiss, Sebastian, Franklin, Jessica, Shrank, William, Brennan, Troyen   +9 more
core   +1 more source