Analysis of Fusarium secondary metabolites through OSMAC strategy
, 2023 [EN] Fungal secondary metabolites (SMs) have been brought to the spotlight due to their numerous promising properties in different fields of the industry, and therefore the research focused on the discovery of novel compounds has considerably increased through the last decades.
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Analysis of Fusarium secondary metabolites through OSMAC strategy [PDF]
, 2022 [EN] Fungal secondary metabolites (SMs) have been brought to the spotlight due to their numerous promising properties in different fields of the industry, and therefore the research focused on the discovery of novel compounds has considerably increased ...
Díaz Fernández de Quincoces, Lorena
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Prioritizing Natural Product Diversity in a Collection of 146 Bacterial Strains Based on Growth and Extraction Protocols [PDF]
, 2016 In order to expedite the rapid and efficient discovery and isolation of novel specialized metabolites, while minimizing the waste of resources on rediscovery of known compounds, it is crucial to develop efficient approaches for strain prioritization ...
Cr�semann, Max +8 more
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Microbial Biotechnology, Volume 17, Issue 8, August 2024.
Miriam Rodríguez +5 more
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Exploiting gene regulation as an approach to identify, analyze and utilize the biosynthetic pathways of the glycopeptide ristomycin A and the zincophore [S,S]-EDDS in Amycolatopsis japonicum [PDF]
, 2017 The microbial secondary metabolism is a rich source for valuable products that have found their way into various clinical and industrial applications. A particularly productive bacterial genus for the discovery of natural products is Amycolatopsis.
Spohn, Marius
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Improvement in flavonoids production combining different strategies [PDF]
, 2022 Synthetic Biology of Natural Products Conference (3rd. 2022. Cancún, México)Different strategies have been used in Streptomyces albus to improve the titers of the flavonoid naringenin, as a heterologously produced plant secondary metabolite.
Lombó Brugos, Felipe +4 more
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OSMAC Strategy: An Affordable Method for the Discovery of New Microbial Compounds
Revista Virtual de Química, 2022 Raissa Rezende Ferreira +2 more
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Exploitation of underused Streptomyces through a combined metabolomics-genomics workflow to enhance natural product diversity. [PDF]
, 2020 The genus Streptomyces is the source of approximately two-thirds of all clinically-used antibiotics. Despite being the source of so many specialised metabolites, genomic analysis indicates that most Streptomyces strains have the potential to produce ...
Burns, Joshua
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Macrolactin XY, a Macrolactin Antibiotic from Marine-Derived Bacillus subtilis sp. 18
Marine DrugsTwo new compounds, macrolactin XY (1) and (5R, 9S, 10S)-5-(hydroxymethyl)-1,3,7-decatriene-9,10-diol (2), together with nine known compounds (3–11) were isolated from the marine Bacillus subtilis sp. 18 by the OSMAC strategy.
Yao Xu +6 more
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Efficient subsampling for exponential family models
, 2023 We propose a novel two-stage subsampling algorithm based on optimal design principles. In the first stage, we use a density-based clustering algorithm to identify an approximating design space for the predictors from an initial subsample.
Dasgupta, Subhadra, Dette, Holger
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