Results 151 to 160 of about 1,148 (180)

Halogenated meroterpenoids with antifungal activities from the Deep-Sea-Derived fungus Acremonium sclerotigenum guided by the genomic and OSMAC strategy

Bioorganic Chemistry
Thirteen new meroterpenoids, acremorins A-M (1, 2, 4, 6, 7 and 9-16), together with three known analogues (3, 5 and 8) were isolated from the deep-sea-derived fungus Acremonium sclerotigenum LW14 guided by the genomic and OSMAC strategy. Their structures and absolute configurations were established by extensive spectroscopic analysis, electronic ...
Ruiyun, Huo, Xiaoqi, Sun, Yu, Tu, Guangrong, Zi, Ling, Liu   +4 more
openaire   +2 more sources

A combination of genome mining with OSMAC strategy facilitates the discovery of bioactive metabolites produced from termite‐associated Streptomyces tanashiensisBYF‐112

Pest Management Science
AbstractBACKGROUNDPreviously, eight new alkaloids were obtained from the fermentation extract of termite‐associated Streptomyces tanashiensis BYF‐112. However, genome analysis indicated the presence of many undiscovered secondary metabolites in S.
Jun Wu, YiHeng Wang, YaXuan Wang, XiaoHong Li, YueYue Li, Miao Zhang, JianHao Xiong, CaiPing Yin, ShuXiang Zhang, XinHua Liu, YingLao Zhang   +10 more
openaire   +2 more sources

The OSMAC strategy unveils new naphthopyranon and diverse bioactive metabolites from termite‐associated Aspergillus chevalieri BYST01

Pest Management Science
Abstract BACKGROUND Despite the revelation of numerous uncharacterized biosynthetic gene clusters (BGCs) in the termite‐associated fungus Aspergillus chevalieri BYST01 through genome mining, no suitable culture conditions have ...
Zhong‐di Huang, Wei‐yu Wang, Ming‐xin Xu, Shu‐xiang Zhang, Cai‐ping Yin, Bo Kong, Xiao‐ying Zhang, Ying‐lao Zhang   +7 more
openaire   +1 more source

Patient navigation across the cancer care continuum: An overview of systematic reviews and emerging literature

Ca-A Cancer Journal for Clinicians, 2023
Matthew Tieu, Jolyn Johal, Nicolas H Hart   +2 more
exaly  

The discovery of bioactive natural products: The isolation and structural elucidation, genome mining, OSMAC strategy, and biotransformation

2023
openaire   +1 more source

Initial Invasive or Conservative Strategy for Stable Coronary Disease

New England Journal of Medicine, 2020
David J Maron, Judith S Hochman, Harmony R Reynolds   +2 more
exaly  

Enhancing Chemical Diversity of Fungal Secondary Metabolite by OSMAC Strategy

Wangjie Zhu, Huawei Zhang
openaire   +1 more source

Patient Decision Aids for Prostate Cancer Treatment: A Systematic Review of the Literature

Ca-A Cancer Journal for Clinicians, 2009
Sara J Knight
exaly  

Molecular cancer prevention: Current status and future directions

Ca-A Cancer Journal for Clinicians, 2015
Kenneth Y Tsai, Powel H Brown, Eva Szabo
exaly  

Drug combinations: a strategy to extend the life of antibiotics in the 21st century

Nature Reviews Microbiology, 2019
Mike Tyers, Gerard D Wright
exaly