New piperazine derivatives helvamides B–C from the marine-derived fungus Penicillium velutinum ZK-14 uncovered by OSMAC (One Strain Many Compounds) strategy [PDF]
Natural Products and BioprospectingFour extracts of the marine-derived fungus Penicillium velutinum J.F.H. Beyma were obtained via metal ions stress conditions based on the OSMAC (One Strain Many Compounds) strategy.
Gleb V. Borkunov +15 more
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Rapid Discovery of Substances with Anticancer Potential from Marine Fungi Based on a One Strain–Many Compounds Strategy and UPLC-QTOF-MS [PDF]
Marine Drugs, 2023 The secondary metabolites of marine fungi with rich chemical diversity and biological activity are an important and exciting target for natural product research. This study aimed to investigate the fungal community in Quanzhou Bay, Fujian, and identified
Yu-Ting Wu +9 more
doaj +2 more sources
Allelopathic Polyketides from an Endolichenic Fungus Myxotrichum SP. by Using OSMAC Strategy. [PDF]
Sci Rep, 2016 AbstractThree new polyketides myxotritones A-C (2–4), together with a new natural product 7,8-dihydro-7R,8S-dihydroxy-3,7-dimethyl-2-benzopyran-6-one (1) were obtained from the endolichenic fungus Myxotrichum sp. by using OMSAC (One Strain, Many Compounds) method.
Yuan C +7 more
europepmc +4 more sources
Bivariate One Strain Many Compounds Designs Expand the Secondary Metabolite Production Space in Corallococcus coralloides [PDF]
Microorganisms, 2023 The scarcely investigated myxobacterium Corallococcus coralloides holds a large genome containing many uncharacterized biosynthetic gene clusters (BGCs) that potentially encode the synthesis of entirely new natural products. Despite its promising genomic
Anton Lindig +4 more
doaj +2 more sources
OSMAC-Based Discovery and Biosynthetic Gene Clusters Analysis of Secondary Metabolites from Marine-Derived Streptomyces globisporus SCSIO LCY30 [PDF]
Marine Drugs, 2023 The one strain many compounds (OSMAC) strategy is an effective method for activating silent gene clusters by cultivating microorganisms under various conditions.
Yanqing Li +7 more
doaj +2 more sources
New Eremophilane-Type Sesquiterpenes from the Marine Sediment-Derived Fungus Emericellopsis maritima BC17 and Their Cytotoxic and Antimicrobial Activities [PDF]
Marine Drugs, 2023 The fungal strain BC17 was isolated from sediments collected in the intertidal zone of the inner Bay of Cadiz and characterized as Emericellopsis maritima.
Jorge R. Virués-Segovia +10 more
doaj +3 more sources
Alkaloid diversity expansion of a talent fungus Penicillium raistrichii through OSMAC-based cultivation [PDF]
Frontiers in Microbiology, 2023 IntroductionAlkaloidal natural products are attractive for their broad spectrum of pharmaceutical bioactivities. In the present work, the highly productive saline soil derived fungus, Penicillium raistrichii, was subjected to the strategy of OSMAC (one ...
Meijia Zhong +4 more
doaj +2 more sources
Metabolomic Strategies to Improve Chemical Information from OSMAC Studies of Endophytic Fungi
Metabolites, 2023 Metabolomics strategies are important tools to get holistic chemical information from a system, but they are scarcely applied to endophytic fungi to understand their chemical profiles of biosynthesized metabolites. Here Penicillium sp. was cultured using
Fernanda Motta Ribeiro da Silva +4 more
doaj +3 more sources
Studies on Secondary Metabolites of Streptomyces gossypiisoli TRM 44567 under the Guidance of OSMAC Strategy [PDF]
Polish Journal of MicrobiologyStreptomycetes synthesize a wide variety of biologically active compounds, such as antimicrobials, enzyme blockers, insecticides, and weed killers, offering the potential for use in farming as agents for enhancing plant health and defense.
CHEN YI HUANG +6 more
doaj +2 more sources
Revolutionizing microbial treasure troves: innovative strategies for natural products discovery [PDF]
Natural Products and BioprospectingMicroorganisms represent Earth's most abundant biological resource, producing metabolites of immense value across medicine, agriculture, and industry. Conventional cultivation and screening techniques, however, suffer from inefficiency and fail to meet ...
Yu-Jie Li, Ming-Hua Qiu, Xing-Rong Peng
doaj +2 more sources