Results 21 to 30 of about 1,148 (180)

Genomic scanning enabling discovery of a new antibacterial bicyclic carbamate-containing alkaloid [PDF]

Synthetic and Systems Biotechnology, 2021
Non-ribosomal peptides are a group of structurally diverse natural products with various important therapeutic and agrochemical applications. Bacterial pyrrolizidine alkaloids (PAs), containing a scaffold of two fused five-membered ring system with a ...
Qing Fang, Linrui Wu, Caroline Urwald, Morgane Mugat, Shan Wang, Kwaku Kyeremeh, Carol Philips, Samantha Law, Yongjun Zhou, Hai Deng   +9 more
doaj   +3 more sources

Discovery of Secondary Metabolites from the Sponge-Derived Fungus Aspergillus templicola [PDF]

Marine Drugs
Combining biosynthetic gene cluster analysis with the OSMAC strategy, fractionation of the fermentation extract of Aspergillus templicola from the sponge Agelas sp. led to the isolation of four novel cytochalasins, colachalasins J–M (1–4), a novel cyclic
Kai Li, Yue Zhang, Lei Li, Sen Wang, Cili Wang, Pinglin Li   +5 more
doaj   +2 more sources

Polyketide Derivatives from the Mangrove-Derived Fungus Penicillium sp. HDN15-312 [PDF]

Marine Drugs
Four new polyketides, namely furantides A–B (1–2), talamin E (3) and arugosinacid A (4), and two known polyketides were obtained from the mangrove-derived fungus Penicillium sp. HDN15-312 using the One Strain Many Compounds (OSMAC) strategy.
Fuhao Liu, Wenxue Wang, Feifei Wang, Luning Zhou, Guangyuan Luo, Guojian Zhang, Tianjiao Zhu, Qian Che, Dehai Li   +8 more
doaj   +2 more sources

Isolation, Structural Elucidation, and Biological Evaluation of Pyrrole-Based Alkaloids from Sea Anemone-Associated Streptomyces sp. S1502 [PDF]

Marine Drugs
Three new pyrrole alkaloids, streptopyrroles D–F (1–3), along with four known analogs (4–7) were isolated from Sea Anemone-Associated Streptomyces sp. S1502 via an OSMAC (One Strain Many Compounds)-based strategy. Their structures were elucidated through
Xin Zhang, Qihong Yang, Le Zhou, Yingying Chen, Jianhua Ju, Junying Ma   +5 more
doaj   +2 more sources

Harnessing Cyanobacteria’s Bioactive Potential: A Sustainable Strategy for Antioxidant Production [PDF]

Microorganisms
Unsaturated diacylglycerols are a class of antioxidant compounds with the potential to positively impact human health. Their ability to combat oxidative stress through radical scavenger activity underscores their significance in the context of preventive
Teresa De Rosa, Maria Ponticelli, Roberta Teta, Vittorio Carlucci, Luigi Milella, Germana Esposito, Valeria Costantino   +6 more
doaj   +4 more sources

New Polyketide Congeners with Antibacterial Activities from an Endophytic Fungus Stemphylium globuliferum 17035 (China General Microbiological Culture Collection Center No. 40666) [PDF]

Journal of Fungi
Four new polyketides, heterocornol Y (1), stemphyindan (2), pestalospirane C (3), and stemphyspyrane (4), along with five known ones (5–9) were isolated from the endophytic fungus Stemphylium globuliferum 17035 (SG17035) based on the One Strain Many ...
Yingying Li, Guoliang Zhu, Jing Wang, Junjie Yu, Ke Ye, Cuiping Xing, Biao Ren, Bin Zhu, Simin Chen, Lijun Lai, Yue Li, Tom Hsiang, Lixin Zhang, Xueting Liu, Jingyu Zhang   +14 more
doaj   +2 more sources

New cytotoxic indole derivatives with anti-FADU potential produced by the endophytic fungus Penicillium oxalicum 2021CDF-3 through the OSMAC strategy

Frontiers in Microbiology
Fungi possess well-developed secondary metabolism pathways that are worthy of in-depth exploration. The One Strain Many Compounds (OSMAC) strategy is a useful method for exploring chemically diverse secondary metabolites.
Wei Song, Lianlian Ji, Yanxia Zhang, Longhe Cao   +3 more
doaj   +3 more sources

Optimal Surrogate-Assisted Sampling for Cost-Efficient Validation of Electronic Health Record Outcomes. [PDF]

Stat Med
ABSTRACT Electronic Health Record (EHR) databases are an increasingly valuable resource for observational studies. However, misclassification of EHR‐derived outcomes due to imperfect phenotyping leads to bias, inflated type I error, and reduced power in risk‐factor association studies. On the other hand, manual chart review to validate outcomes is both
Marks-Anglin A, Chen J, Luo C, Hubbard R, Chen Y.   +4 more
europepmc   +2 more sources

Activation of the Dimer of 3, 4-dimethylphenol Production From Marine Streptomyces sp. FJNU027 Under Oligotrophic Condition. [PDF]

Microbiologyopen
This study assessed the potential for secondary metabolites production of marine Streptomyces sp. FJNU027 under various media. It was found the FJNU027 strain produced a differential compound in oligotrophic medium. The pure compound was obtained through mass fermentation, extraction and isolation, and identified as the dimer of 3, 4‐dimethylphenol ...
Wang F, Yuan H, Bai C, Li H, Xu L, Yu L, Luo L, Zheng Y.   +7 more
europepmc   +2 more sources

DETECTION OF ANTIMICROBIAL COMPOUNDS FROM THERMOPHILIC ACTINOMYCETES USING ONE STRAIN MANY COMPOUNDS (OSMAC) APPROACH [PDF]

, 2022
Actinomycetes are a group of filamentous bacteria with high biosynthetic potential that can produce secondary metabolites. Actinomycetes are known to produce secondary metabolites which are potential as antimicrobial, antitumor, and others. Actinomycetes
Ningsih, Fitria, Sjamsuridzal, Wellyzar, Zahroh, Endah Wati   +2 more
core   +3 more sources