Results 31 to 40 of about 1,148 (180)

Uncovering Phytotoxic Compounds Produced by Colletotrichum spp. Involved in Legume Diseases Using an OSMAC–Metabolomics Approach

open access: yesJournal of Fungi, 2023
Different fungal species belonging to the Colletotrichum genus cause anthracnose disease in a range of major crops, resulting in huge economic losses worldwide. Typical symptoms include dark, sunken lesions on leaves, stems, or fruits. Colletotrichum spp.
Pierluigi Reveglia   +5 more
doaj   +1 more source

Cryptic Metabolites from Marine-Derived Microorganisms Using OSMAC and Epigenetic Approaches

open access: yesMarine Drugs, 2022
Marine microorganisms have proven to be a source of new natural products with a wide spectrum of biological activities relevant in different industrial sectors.
Cristina Pinedo-Rivilla   +2 more
doaj   +1 more source

Nocathioamides, Uncovered by a Tunable Metabologenomic Approach, Define a Novel Class of Chimeric Lanthipeptides

open access: yesAngewandte Chemie, Volume 133, Issue 30, Page 16608-16615, July 19, 2021., 2021
Chimeric Lanthipeptides: Employing a tunable metabologenomic approach, nocathioamides A–C were isolated and elucidated. They inaugurate a new RiPP family, characterized by a unique and hyper degree of modifications, including an intramolecular imide bridge.
Hamada Saad   +7 more
wiley   +2 more sources

Aromatic compounds from the endophytic fungus Asordaria conoidea and their allelochemical property using OSMAC strategy

open access: yesNatural Product Research, 2021
Endophytic fungi are biodiverse and alternative source of bioactive compounds, due their different abilities of genetic expression and alteration of biosynthetic pathway when submitted to different culture conditions. The metabolic profile of three different crude extracts (A, B and C), obtained from the endophytic fungus Asordaria conoidea, were ...
Arruda, Gabriel Leda de   +4 more
openaire   +3 more sources

Discovery and excavation of lichen bioactive natural products

open access: yesFrontiers in Microbiology, 2023
Lichen natural products are a tremendous source of new bioactive chemical entities for drug discovery. The ability to survive in harsh conditions can be directly correlated with the production of some unique lichen metabolites.
Meirong Ren   +5 more
doaj   +1 more source

Unveiling the Substrate-Dependent Dynamics of Mycotoxin Production in Fusarium verticillioides Using an OSMAC-Metabolomics Approach. [PDF]

open access: yesChem Biodivers
Abstract Fusarium verticillioides is a prevalent plant pathogenic fungus known to produce harmful mycotoxins, including fumonisins and emerging toxins. This study aimed to investigate the influence of substrate on the temporal patterns of mycotoxin biosynthesis by F.
Groppi E   +4 more
europepmc   +2 more sources

Induced secondary metabolites of the beneficial fungus Trichoderma harzianum M10 through OSMAC approach

open access: yesChemical and Biological Technologies in Agriculture, 2023
Background Fungi biosynthesize a wide range of chemically diverse secondary metabolites during processes of competition with other micro- and macro-organisms, symbiosis, parasitism, or pathogenesis.
Alessia Staropoli   +5 more
doaj   +1 more source

Copper and manganese cations alter secondary metabolism in the fungus Penicillium brasilianum [PDF]

open access: yes, 2021
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESThe fungus Penicillium brasilianum LaBioMMi 136 was ...
Amaral, Luciana da Silva   +8 more
core   +1 more source

Genome Mining and Metabolic Profiling Reveal Cytotoxic Cyclodipeptides in Streptomyces hygrospinosus var. Beijingensis

open access: yesAntibiotics, 2022
Two new cyclodipeptide (CDP) derivatives (1–2) and another seven known cyclodipeptides (3–9) were isolated from Streptomyces 26D9-414 by the genome mining approach combined with genetic dereplication and the “one strain many compounds” (OSMAC) strategy ...
Dashan Zhang   +6 more
doaj   +1 more source

Advances in Synthetic Biology of Fungi and Contributions to the Discovery of New Molecules

open access: yesChemBioChem, Volume 24, Issue 11, June 1, 2023., 2023
High‐throughput activation of cryptic BGCs. Putative biosynthetic gene clusters can be identified by screening all available fungal genomes. The relevant genes are then assembled to promote simultaneous expression of the involved genes. Plasmids are transferred into chassis organisms, and positive colonies are cultivated to identify new metabolites ...
Vito Valiante
wiley   +1 more source

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