Results 51 to 60 of about 1,148 (180)

Genetics of Polyketide Metabolism in Aspergillus nidulans [PDF]

, 2012
metabolite
Adams, Bailey, Bergmann, Bergmann, Birkinshaw, Blount, Brechbühler, Brown, Bullock, Chang, Chang, Chen, Chen, Chiang, Chung, Couch, Crawford, Ehrlich, Ehrlich, Fujita, Fukuyama, Fukuyama, Halo, Halo, Hatsuda, Hatsuda, Henry, Holker, Howard, Kelkar, Kelkar, Keller, Keller, Krappmann, Li, Liu, Marshall, Mayorga, McDonald, McInnes, Meyers, Neelakantan, Nekam, O’Hara, Pontecorvo, Sanchez, Scott, Silva, Simpson, Simpson, Sims, Szewczyk, Terao, Trail, Watanabe, Watanabe, Xu, Yabe, Yabe, Yadav, Yu, Yu, Yuill   +62 more
core   +4 more sources

Cytotoxic potential of Nephthea sp.-derived actinomycetes supported by metabolomics analysis [PDF]

, 2022
Soft corals and associated microorganisms are known to produce leads for anticancer drugs. Keeping this in mind, Nephthea sp.; a Red Sea soft coral was investigated for the first time using the OSMAC approach. Two isolates, Streptomyces sp.
Abdelhafez, Omnia Hesham, Abdelmohsen, Usama Ramadan, Fahim, John Refaat, Ngwa, Che J., Pradel, Gabriele, Rateb, Mostafa E.   +5 more
core   +2 more sources

Three new polyketides from Ascotricha sp. ZJ-M-5 by the OSMAC strategy

Journal of Asian Natural Products Research, 2018
Three new compounds, ascotrichols A-B (1–2) and ascotrichrone A (3), along with two known isocoumarin derivatives (4–5), were isolated from the solid culture of a sea mud-derived fungus, Ascotricha sp. ZJ-M-5 on rice media. The structures were elucidated by extensive spectroscopic analyses, including 1D and 2D NMR data, and the absolute configurations ...
Ya-Jing Dong, Guo-Mei Hou, Bin Lin, Dan-Yi Li, Zhan-Lin Li   +4 more
openaire   +2 more sources

Natural product libraries: Assembly, maintenance, and screening [PDF]

, 2014
This review discusses successful strategies and potential pitfalls to assembling a natural product-based library suitable for high-throughput screening. Specific extraction methods for plants, microorganisms, and marine invertebrates are detailed, along ...
Butler, Mark S., Cooper, Matthew A., Fontaine, Frank   +2 more
core   +1 more source

Selecting for useful properties of plants and fungi – Novel approaches, opportunities, and challenges

PLANTS, PEOPLE, PLANET, Volume 2, Issue 5, Page 409-420, September 2020., 2020
For millennia, humans have used plants and fungi, as foods, fuels, fibers, and medicines; and have developed techniques for improving their usefulness to our species, mostly through selection of desirable traits. With human populations forecast to rise, the availability of arable land likely to fall amid climate change and increasing urbanization, and ...
Paul J. Kersey, Jerome Collemare, Christopher Cockel, Dibakar Das, Ehsan M. Dulloo, Laura J. Kelly, Eoin Lettice, Valery Malécot, Nigel Maxted, Carey Metheringham, Imke Thormann, Ilia J. Leitch   +11 more
wiley   +1 more source

Evolution‐Guided Discovery of Antimycobacterial Triculamin‐Like Lasso Peptides

Angewandte Chemie, Volume 137, Issue 20, May 12, 2025.
The hypothesized convergent biosynthesis of triculamin‐like lasso peptides from different biosynthetic gene cluster (BGC) types represented across multiple bacterial phyla. The elucidation of the triculamin non‐canonical BGC and resistance mechanism by heterologous expression in Streptomyces albus and in vitro acetylation with resistance conveying ...
Aske Merrild, Tiziana Svenningsen, Marc G. Chevrette, Thomas Tørring   +3 more
wiley   +2 more sources

Bioprospecting of marine phytoplankton from large scale cultivation - Effect of culture conditions on bioactivity and biochemistry of the diatom Porosira glacialis [PDF]

, 2021
The diatoms make up the largest and most important group of marine microalgae. They are responsible for a quarter of all inorganic carbon fixation in the ocean and are thus of immense importance for global CO2 sequestration.
Osvik, Renate Døving
core   +1 more source

New Dibenzo-α-pyrone Derivatives with α-Glucosidase Inhibitory Activities from the Marine-Derived Fungus Alternaria alternata

Marine Drugs, 2022
Three new dibenzo-α-pyrone derivatives, alternolides A–C (1–3), and seven known congeners (4–10) were isolated from the marine-derived fungus of Alternaria alternata LW37 assisted by the one strain-many compounds (OSMAC) strategy.
Jinxin Zhang, Baodan Zhang, Lei Cai, Ling Liu   +3 more
doaj   +1 more source

Eight new cyclopentenone and cyclohexenone derivatives from the marine-derived fungus Aspergillus sp. SCSIO 41501 by OSMAC strategy

Natural Product Research, 2020
One strain many compounds (OSMAC) strategy was an effective method to activate the silent biosynthetic genes of microorganisms. Comparison with our previous investigations on the secondary metabolites of the marine-derived fungus Aspergillus sp. SCSIO 41501, in this study, three new cyclopentenone derivatives, aspergispones A-C (1–3), and five new ...
Fei-Hua, Yao, Xiao, Liang, Shu-Hua, Qi
openaire   +2 more sources

Sulfur-containing benzofurans and α-pyrones from the mangrove-derived fungus Talaromyces sp. WHUF0341

Frontiers in Marine Science, 2022
Two new sulfur-containing benzofurans, talarobenzofurans A and B (1 and 2), one new benzofuran talarobenzofuran C (3) and two new α-pyrones talaropyrones A and B (5 and 6), along with five known compounds eurothiocin A (4), nodulisporipyrone A (7 ...
Ruohan Zhang, Ruohan Zhang, Jinxin Zhang, Jinxin Zhang, Ruiyun Huo, Ruiyun Huo, Yaxin Xue, Kui Hong, Ling Liu, Ling Liu   +9 more
doaj   +1 more source