Results 71 to 80 of about 1,148 (180)

Exploring deep-sea Actinomycetota chemical diversity by using the OSMAC approach

Frontiers in Marine Science
The constant need to search for new drugs is a major driver for the discovery of new molecules of pharmaceutical interest. Natural products (NPs) of microbial origin have been recognized for their therapeutic properties, with Actinomycetota being one of ...
Sofia Correia, Sofia Correia, Inês Ribeiro, Andreia Braga-Henriques, Andreia Braga-Henriques, Andreia Braga-Henriques, Andreia Braga-Henriques, Andreia Braga-Henriques, Pedro N. Leão, Ralph Urbatzka, Maria F. Carvalho, Maria F. Carvalho   +11 more
doaj   +1 more source

Production of a Novel Tetrahydroxynaphthalene (THN) Derivative from Nocardia sp. CS682 by Metabolic Engineering and Its Bioactivities

Molecules, 2019
Nargenicin A1 is major secondary metabolite produced by Nocardia sp. CS682, with an effective antibacterial activity against various Gram-positive bacteria. Most Nocardia spp.
Ravindra Mishra, Dipesh Dhakal, Jang Mi Han, Haet Nim Lim, Hye Jin Jung, Tokutaro Yamaguchi, Jae Kyung Sohng   +6 more
doaj   +1 more source

Product strategies for packaged software : an exploratory analysis of the spreadsheet market [PDF]

, 1993
Thesis (M.S.)--Massachusetts Institute of Technology, Sloan School of Management, 1993.Includes bibliographical references (p. 101-113).by Donna D. Mayo and Daniel A.
Mayo, Donna D. (Donna Dorothy), Young, Daniel A   +1 more
core  

Amazonian Cyanobacteria as a Source of Bioactive Compounds With Antimicrobial and Cytotoxic Properties

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT Cyanobacteria are photosynthetic microorganisms known for producing diverse bioactive compounds. This study explores the bioactivity of extracts and fractions from Amazonian cyanobacteria and their pigment and phenolic compound production. A fraction from Synechococcus sp. CACIAM 05 showed cytotoxicity against hCMEC/D3 and MG‐63 cells.
Samuel Cavalcante do Amaral, Luciana Pereira Xavier, Mariana Reis, Rhuana V. Médice, Janaína Morone, Raquel Silva, João Morais, Vitor Vasconcelos, Agenor Valadares Santos   +8 more
wiley   +1 more source

Exploration of Natural Product Repository by Combined Genomics and Metabolomics Profiling of Mangrove-Derived Streptomyces murinus THV12 Strain

Fermentation, 2023
Streptomyces, one of the largest genera belonging to the phylum Actinobacteria, contribute to more than 60% of the clinically relevant antibiotics. The present study outlined the genomics and the metabolomics of a mangrove-derived Streptomyces murinus ...
Vineetha Das, Niladri Sekhar Chatterjee, Prinetha Uruparambil Pushpakaran, Kuttanappilly V. Lalitha, Toms C. Joseph   +4 more
doaj   +1 more source

Promoter Activation in Δhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing

Angewandte Chemie, Volume 131, Issue 52, Page 19133-19139, December 19, 2019., 2019
Von der Vielzahl zu keinem kehr wieder zu einem! Der gezielte Promotoraustausch in Δhfq Mutanten von Proteobakterien erlaubt die Generierung von Stämmen, die ausschließlich einen Naturstoff bzw. eine Naturstoffklasse überproduzieren. Die Verwendung dieser Stämme vereinfacht nicht nur die Isolierung und Strukturaufklärung ausgewählter Naturstoffe ...
Edna Bode, Antje K. Heinrich, Merle Hirschmann, Desalegne Abebew, Yan‐Ni Shi, Tien Duy Vo, Frank Wesche, Yi‐Ming Shi, Peter Grün, Svenja Simonyi, Nadine Keller, Yvonne Engel, Sebastian Wenski, Reuel Bennet, Sophie Beyer, Iris Bischoff, Anthony Buaya, Sophie Brandt, Ibrahim Cakmak, Harun Çimen, Simone Eckstein, Denia Frank, Robert Fürst, Martin Gand, Gerd Geisslinger, Selcuk Hazir, Marina Henke, Ralf Heermann, Virginie Lecaudey, Wilhelm Schäfer, Susanne Schiffmann, Anja Schüffler, Rebecca Schwenk, Marisa Skaljac, Eckhard Thines, Marco Thines, Thomas Ulshöfer, Andreas Vilcinskas, Thomas A. Wichelhaus, Helge B. Bode   +39 more
wiley   +1 more source

Solanum nigrum: A review study with anti-cancer and antitumor perspective [PDF]

, 2016
Solanum nigrum or locally just black nightshade is a species in the Solanum genus, native to Eurasia and introduced in the Americas, Australasia, and South Africa.
Miraj, S.
core  

Pleosporalins H and I, two new heptaketides from the endophytic fungus Pleosporales sp. F46 by using OSMAC strategy

Natural Product Research, 2019
Two new heptaketides, pleosporalins H and I (1 and 2), as well as seven biosynthetically related known polyketides (3–9) were isolated from the endophytic fungus, Pleosporales sp. F46 by employing the one strain-many compounds (OSMAC) approach. The planar, relative and absolute structures of these compounds were identified by extensive spectroscopic ...
Hong-Xia Yang, Xiao-Ping Peng, Han Gao, Hui-Min Zhang, Zi-Ru Wang, Gang Li, Hong-Xiang Lou   +6 more
openaire   +2 more sources

Bioactive Alkaloids from the Marine-Derived Fungus Metarhizium sp. P2100

Journal of Fungi, 2022
The Metarhizium fungal species are considered the prolific producers of bioactive secondary metabolites with a variety of chemical structures. In this study, the biosynthetic potential of marine-derived fungus Metarhizium sp.
Guang-Shan Yao, Zhong-Lian Ma, Yao-Yao Zheng, Ling Lv, Jun-Qiu Mao, Chang-Yun Wang   +5 more
doaj   +1 more source

The 9th European Conference on Marine Natural Products [PDF]

, 2015
Acknowledgments This work was supported by grants from the European Commission within its FP7 Programme, under the thematic area KBBE.2012.3.2-01 with Grant Number Nos. 311932 “SeaBioTech”, 311848 “BlueGenics”, and 312184 PharmaSea.Peer reviewedPublisher
Edrada-Ebel, RuAngelie, Jaspars, Marcel
core   +2 more sources