Results 81 to 90 of about 1,148 (180)

Identification of Bioactive Molecules from Arctic Marine Arthrobacter Isolates [PDF]

, 2021
In this study, five isolated Arctic marine bacteria of the genus Arthrobacter were cultivated under different temperatures and growth media. Employing the “One Strain-Many Compounds” (OSMAC) approach, in an attempt to produce novel and interesting ...
Trosten, Ella
core  

Integrated genome and metabolome mining unveiled structure and biosynthesis of novel lipopeptides from a deep‐sea Rhodococcus

Microbial Biotechnology, Volume 17, Issue 11, November 2024.
Combining genome mining and mass spectrometry‐based metabolomics disclosed the deep‐sea Rhodococcus sp. I2R as a source of two families of novel lipopeptide biosurfactants with antiproliferative activity against human A375 melanoma cells. Abstract Microbial biosurfactants have garnered significant interest from industry due to their lower toxicity ...
Costanza Ragozzino, Fortunato Palma Esposito, Carmine Buonocore, Pietro Tedesco, Daniela Coppola, Davide Paccagnella, Nadine Ziemert, Gerardo Della Sala, Donatella de de Pascale   +8 more
wiley   +1 more source

Harnessing Gram‐negative bacteria for novel anti‐Gram‐negative antibiotics

Microbial Biotechnology, Volume 17, Issue 11, November 2024.
In this mini‐review, we highlight prominent examples of novel anti‐Gram negative natural products produced by isolated Gram‐negative bacteria that are currently in pre‐clinical development. Furthermore, we will provide insights into the considerations and strategies behind the discovery of these agents and their putative applications.
Joy Birkelbach, Carsten E. Seyfert, Sebastian Walesch, Rolf Müller   +3 more
wiley   +1 more source

Global metabolome changes induced by environmentally relevant conditions in a marine-sourced Penicillium restrictum

Comptes Rendus. Chimie
Marine fungi have been found in all habitats and are able to adapt to their environmental niche conditions. In this study, a combination of liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) and gas chromatography coupled to ...
Le, Van-Tuyen, Bertrand, Samuel, Brandolini-Bunlon, Marion, Gentil, Emmanuel, Robiou du Pont, Thibaut, Rabesaotra, Vony, Wielgosz-Collin, Gaëtane, Mossion, Aurélie, Grovel, Olivier   +8 more
doaj   +1 more source

Molecular Networking Analysis and Antibacterial Potential of Ethyl Acetate Extracts of Sinomicrobium sp. PAP.21 using OSMAC Method [PDF]

Challenges in drug discovery include biosynthetic gene clusters which remain silent under standard laboratory culture conditions. On the other hand, the rediscovery of the known compounds is inevitable.
Harwoko, Harwoko, Rahmawati, Anggun Tri, Riyanti, Riyanti   +2 more
core   +2 more sources

OSMaC strategies to discover new natural products

, 2023
As cianobactérias são microrganismos fotossintéticos capazes de produzir uma larga gama de produtos secundários, desde toxinas a outros compostos com aplicações biotecnológicas e farmacêuticas reconhecidas. Recentes avanços na Genómica e Bioinformática têm vindo a demonstrar que os genomas das cianobactérias codificam para mais conjuntos de genes ...
openaire   +1 more source

Implementation of the novel high-throughput Fungal Isolation one step Device method FIND and secondary metabolite extraction from the isolate Heydenia cf. alpina [PDF]

, 2021
Fungi are an important source of bioactive metabolites. The cultivation of source organisms is a crucial step in natural product isolation. With standard isolation methods for fungi it is difficult to isolate rare und underexamined fungi from ...
Libor, Benjamin
core  

Cyclodepsipeptides and Sesquiterpenes from Marine-Derived Fungus Trichothecium roseum and Their Biological Functions

Marine Drugs, 2018
On the basis of the ‘one strain, many compounds’ (OSMAC) strategy, chemical investigation of the marine-derived fungus Trichothecium roseum resulted in the isolation of trichomide cyclodepsipeptides (compounds 1⁻4) from PDB medium, and ...
Yuan-Ming Zhou, Guang-Lin Ju, Lin Xiao, Xiang-Fei Zhang, Feng-Yu Du   +4 more
doaj   +1 more source

Complexity of fungal polyketide biosynthesis and function

Molecular Microbiology, Volume 121, Issue 1, Page 18-25, January 2024.
Fungal secondary metabolites are the basis of many pharmaceuticals. Fungal genome analyses revealed a huge, but yet unexplored potential for more and new secondary metabolites. The review focuses on polyketides, their biosynthesis, their natural functions, and strategies for new discoveries of compounds and functions.
Maria C. Stroe, Jia Gao, Michael Pitz, Reinhard Fischer   +3 more
wiley   +1 more source

Discovery of new eremophilanes from the marine-derived fungus Emericellopsis maritima BC17 by culture conditions changes: evaluation of cytotoxic and antimicrobial activities [PDF]

In our previous studies, the marine-derived fungus Emericellopsis maritima BC17 was found to produce new eremophilane-type sesquiterpenoids on solid media. In order to explore its potential to produce more metabolites, E. maritima BC17 was subjected to a
Aleu Casatejada, Josefina, de la Cruz, Mercedes, Durán Patrón, Rosa María, Pinedo Rivilla, Cristina, Ramos, María C., Roca Virués de Segovia, Jorge, Sánchez Márquez, Jesús, Sánchez, Pilar, Zorrilla Cuenca, David   +8 more
core   +1 more source