Results 1 to 10 of about 537,667 (292)

Psychosocial and individual factors affecting Quality of Life (QoL) in patients suffering from Achilles tendinopathy: a systematic review

BMC Musculoskeletal Disorders, 2022
Background Achilles tendinopathy (AT) is a joint condition that causes functional restrictions and pain. This condition negatively impacts patients' social connectedness and psychological well-being, reducing their quality of life (QoL). This review aims
Josep Verges, Nina Martínez, Aina Pascual, Marco Bibas, Manel Santiña, Gil Rodas   +5 more
doaj   +1 more source

Dynamic weight-bearing test during jumping: A sensitive outcome measure of chronic osteoarthritis pain in rats

Heliyon, 2021
Pain due to osteoarthritis (OA) often occurs during locomotion in the vertical direction when joints are subjected to high mechanical load, e.g. during standing up from a chair or using stairs.
Andreas Westhof, Kerstin Kleinschmidt-Doerr, Martin Michaelis, Christian Brenneis   +3 more
doaj   +1 more source

Early detection of osteoarthritis in the rat with an antibody specific to type II collagen modified by reactive oxygen species

Arthritis Research & Therapy, 2021
Background Osteoarthritis (OA) is a disease of the whole joint, with articular cartilage breakdown as a major characteristic. Inflammatory mediators, proteases, and oxidants produced by chondrocytes are known to be responsible for driving cartilage ...
Anne Gigout, Donata Harazin, Louise M. Topping, Didier Merciris, Sven Lindemann, Christian Brenneis, Ahuva Nissim   +6 more
doaj   +1 more source

SYSADOAs: do their origin and quality make a difference in efficacy and safety?

Global Rheumatology, 2021
Symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) comprise a heterogeneous group of drugs with a long-term effect on the symptoms of osteoarthritis.
Marianna Vitaloni, Ingrid Möller, Josep Verges   +2 more
doaj   +1 more source

Colony housing promotes structural and functional changes during surgically induced osteoarthritis in rats

Osteoarthritis and Cartilage Open, 2020
Summary: Objective: The aim of the study was to investigate how social housing with high locomotion activity affects experimental osteoarthritis (OA) in rats.
C. Brenneis, S. Menges, A. Westhof, S. Lindemann, C.S. Thudium, K. Kleinschmidt-Doerr   +5 more
doaj   +1 more source

Common Biochemical and Magnetic Resonance Imaging Biomarkers of Early Knee Osteoarthritis and of Exercise/Training in Athletes: A Narrative Review

Diagnostics, 2021
Knee osteoarthritis (OA) is the most common joint disease of the world population. Although considered a disease of old age, OA also affects young individuals and, more specifically among them, those practicing knee-joint-loading sports. Predicting OA at
Johanne Martel-Pelletier, Ginette Tardif, Patrice Paiement, Jean-Pierre Pelletier   +3 more
doaj   +1 more source

Prokineticin 2 is a catabolic regulator of osteoarthritic cartilage destruction in mouse

Arthritis Research & Therapy, 2023
Background Our preliminary study indicates that the multi-functional protein, prokineticin 2 (Prok2), is upregulated in osteoarthritic (OA) chondrocytes as a target of the hypoxia-inducible factor (HIF)-2α.
Jiye Yang, Youngnim Shin, Hwee-Jin Kim, Hyo-Eun Kim, Jang-Soo Chun   +4 more
doaj   +1 more source

Therapeutic Effect of Exosomes Derived From Stem Cells in Spinal Cord Injury: A Systematic Review Based on Animal Studies

Frontiers in Neurology, 2022
ObjectiveA systematic review of the role of stem cell-derived exosomes in repairing spinal cord injury (SCI) and the existing problems in animal experiments to provide a reference for better animal experiments and clinical studies in the future ...
Cangyu Zhang, Cangyu Zhang, Rongrong Deng, Guangzhi Zhang, Guangzhi Zhang, Xuegang He, Xuegang He, Haiwei Chen, Haiwei Chen, Bao Chen, Bao Chen, Lin Wan, Lin Wan, Xuewen Kang, Xuewen Kang   +14 more
doaj   +1 more source

In silico targeting of interleukin-6 by natural compounds

Bangladesh Journal of Pharmacology, 2014
Rheumatoid arthritis an autoimmune disorder affecting many tissues and organs, is a challenging prospect in terms of treatment. Our work is looking into finding lead compound of natural origin against IL-6, an important cyto-kine having a profound role ...
Wei Zhou, Jun-Feng Cai, Feng Yuan, Min Ma, Feng Yin   +4 more
doaj   +1 more source

Two or four injections of platelet-rich plasma for osteoarthritic knee did not change synovial biomarkers but similarly improved clinical outcomes

Scientific Reports, 2021
We compared two and four intra-articular injections of platelet-rich plasma (PRP) in terms of changes of synovial cytokines and clinical outcomes. One hundred twenty-five patients having knee osteoarthritis (OA) underwent PRP injections at a 6-week ...
Srihatach Ngarmukos, Chotetawan Tanavalee, Chavarin Amarase, Suphattra Phakham, Warayapa Mingsiritham, Rangsima Reantragoon, Nitigorn Leearamwat, Thidarat Kongkaew, Kittipan Tharakhet, Sittisak Honsawek, Sinsuda Dechsupa, Aree Tanavalee   +11 more
doaj   +1 more source