Results 1 to 10 of about 302,871 (285)

Impact of Kellgren–Lawrence grade on clinical outcomes following adipose-derived stem cell therapy for knee osteoarthritis: A propensity score–matched retrospective cohort study [PDF]

Cell Transplantation
Knee osteoarthritis (OA) causes pain and disability, and autologous adipose-derived stem cell (ASC) therapy has emerged as a regenerative treatment option.
Naoki Nakano, Tomoyuki Matsumoto, Masanori Tsubosaka, Tomoyuki Kamenaga, Kazunari Ishida, Rinako Osaka, Masaki Otsuji, Norimasa Nakamura, Yuichi Kuroda, Shinya Hayashi, Ryosuke Kuroda   +10 more
doaj   +2 more sources

Osteoarthritis [PDF]

Nature Reviews Disease Primers, 2016
Osteoarthritis (OA) is the most common joint disorder, is associated with an increasing socioeconomic impact owing to the ageing population and mainly affects the diarthrodial joints. Primary OA results from a combination of risk factors, with increasing age and obesity being the most prominent.
Johanne, Martel-Pelletier, Andrew J, Barr, Flavia M, Cicuttini, Philip G, Conaghan, Cyrus, Cooper, Mary B, Goldring, Steven R, Goldring, Graeme, Jones, Andrew J, Teichtahl, Jean-Pierre, Pelletier   +9 more
  +8 more sources

Osteoarthritis [PDF]

Disease-a-Month, 2006
Osteoarthritis (OA), the syndrome of joint pain and dysfunction caused by joint degeneration, affects more people than any other joint disease. In most instances joint degeneration develops in the absence of an identifiable cause, but increasing age, excessive joint loading, and joint abnormalities and insults increase the risk of OA. Articular surface
David J, Hunter, David T, Felson
  +7 more sources

Psychosocial and individual factors affecting Quality of Life (QoL) in patients suffering from Achilles tendinopathy: a systematic review

BMC Musculoskeletal Disorders, 2022
Background Achilles tendinopathy (AT) is a joint condition that causes functional restrictions and pain. This condition negatively impacts patients' social connectedness and psychological well-being, reducing their quality of life (QoL). This review aims
Josep Verges, Nina Martínez, Aina Pascual, Marco Bibas, Manel Santiña, Gil Rodas   +5 more
doaj   +1 more source

Dynamic weight-bearing test during jumping: A sensitive outcome measure of chronic osteoarthritis pain in rats

Heliyon, 2021
Pain due to osteoarthritis (OA) often occurs during locomotion in the vertical direction when joints are subjected to high mechanical load, e.g. during standing up from a chair or using stairs.
Andreas Westhof, Kerstin Kleinschmidt-Doerr, Martin Michaelis, Christian Brenneis   +3 more
doaj   +1 more source

Early detection of osteoarthritis in the rat with an antibody specific to type II collagen modified by reactive oxygen species

Arthritis Research & Therapy, 2021
Background Osteoarthritis (OA) is a disease of the whole joint, with articular cartilage breakdown as a major characteristic. Inflammatory mediators, proteases, and oxidants produced by chondrocytes are known to be responsible for driving cartilage ...
Anne Gigout, Donata Harazin, Louise M. Topping, Didier Merciris, Sven Lindemann, Christian Brenneis, Ahuva Nissim   +6 more
doaj   +1 more source

SYSADOAs: do their origin and quality make a difference in efficacy and safety?

Global Rheumatology, 2021
Symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) comprise a heterogeneous group of drugs with a long-term effect on the symptoms of osteoarthritis.
Marianna Vitaloni, Ingrid Möller, Josep Verges   +2 more
doaj   +1 more source

Colony housing promotes structural and functional changes during surgically induced osteoarthritis in rats

Osteoarthritis and Cartilage Open, 2020
Summary: Objective: The aim of the study was to investigate how social housing with high locomotion activity affects experimental osteoarthritis (OA) in rats.
C. Brenneis, S. Menges, A. Westhof, S. Lindemann, C.S. Thudium, K. Kleinschmidt-Doerr   +5 more
doaj   +1 more source

Common Biochemical and Magnetic Resonance Imaging Biomarkers of Early Knee Osteoarthritis and of Exercise/Training in Athletes: A Narrative Review

Diagnostics, 2021
Knee osteoarthritis (OA) is the most common joint disease of the world population. Although considered a disease of old age, OA also affects young individuals and, more specifically among them, those practicing knee-joint-loading sports. Predicting OA at
Johanne Martel-Pelletier, Ginette Tardif, Patrice Paiement, Jean-Pierre Pelletier   +3 more
doaj   +1 more source

Prokineticin 2 is a catabolic regulator of osteoarthritic cartilage destruction in mouse

Arthritis Research & Therapy, 2023
Background Our preliminary study indicates that the multi-functional protein, prokineticin 2 (Prok2), is upregulated in osteoarthritic (OA) chondrocytes as a target of the hypoxia-inducible factor (HIF)-2α.
Jiye Yang, Youngnim Shin, Hwee-Jin Kim, Hyo-Eun Kim, Jang-Soo Chun   +4 more
doaj   +1 more source