Results 1 to 10 of about 457,754 (279)

Playing sport injured is associated with osteoarthritis, joint pain and worse health-related quality of life: a cross-sectional study

BMC Musculoskeletal Disorders, 2020
Background Sports participants are faced with the decision to continue or cease play when injured. The implications of playing sport while injured on joint health and health-related quality of life (HRQoL) has not been investigated.
Garrett S. Bullock, Gary S. Collins, Nick Peirce, Nigel K. Arden, Stephanie R. Filbay   +4 more
doaj   +1 more source

Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth

Nature Communications, 2022
The study shows that mechanical forces trigger secretion of the extracellular matrix protein dentin matrix protein 1 from osteoblasts. This transforms bone growth-promoting blood vessels into a quiescent subtype to limit bone growth at the end of ...
Maria Dzamukova, Tobias M. Brunner, Jadwiga Miotla-Zarebska, Frederik Heinrich, Laura Brylka, Mir-Farzin Mashreghi, Anjali Kusumbe, Ralf Kühn, Thorsten Schinke, Tonia L. Vincent, Max Löhning   +10 more
doaj   +1 more source

Sprifermin (rhFGF18) modulates extracellular matrix turnover in cartilage explants ex vivo

Journal of Translational Medicine, 2017
Background Sprifermin (recombinant human fibroblast growth factor 18) is in clinical development as a potential disease-modifying osteoarthritis drug (DMOAD).
Ditte Reker, Cecilie F. Kjelgaard-Petersen, Anne Sofie Siebuhr, Martin Michaelis, Anne Gigout, Morten A. Karsdal, Christoph Ladel, Anne C. Bay-Jensen   +7 more
doaj   +1 more source

Physical Activity Minimum Threshold Predicting Improved Function in Adults With Lower‐Extremity Symptoms [PDF]

, 2017
Objective To identify an evidence‐based minimum physical activity threshold to predict improved or sustained high function for adults with lower‐extremity joint symptoms.
Ainsworth, Barbara, Chang, Rowland W., Dunlop, Dorothy D., Ehrlich-Jones, Linda S., Gilbert, Abigail L., Lee, Jungwha, Pellegrini, Christine A., Pinto, Daniel, Semanik, Pamela A., Song, Jing   +9 more
core   +1 more source

Association of malalignment, muscular dysfunction, proprioception, laxity and abnormal joint loading with tibiofemoral knee osteoarthritis - a systematic review and meta-analysis [PDF]

, 2018
Background: To investigate (1) the association of specific biomechanical factors with knee osteoarthritis and knee osteoarthritis development, and (2) the impact of other relevant risk factors on this association.Methods: MEDLINE, EMBASE, CINAHL and ...
Dekker, Joost, Dell'Isola, Andrea, Juhl, Carsten, Lund, Hans, Steultjens, Martijn, Thorland, Jonas B., van Tunen, Joyce A.C.   +6 more
core   +5 more sources

Complicated thromboembolic prophylaxis in the treatment of septic gonitis – case report

Pediatria i Medycyna Rodzinna, 2015
In this paper the case of a patient subjected to orthopaedic treatment with a history of a number of internal comorbidities, cardiac ones in particular, has been reported. Cardiac comorbidities were related to the implantation of a VVI pacemaker.
Adrian Brychcy, Wojciech J. Marczyński, Stanisław Rak   +2 more
doaj   +1 more source

Aging and Osteoarthritis: An Inevitable Encounter?

Journal of Aging Research, 2012
Osteoarthritis (OA) is a major health burden of our time. Age is the most prominent risk factor for the development and progression of OA. The mechanistic influence of aging on OA has different facets.
Thomas Hügle, Jeroen Geurts, Corina Nüesch, Magdalena Müller-Gerbl, Victor Valderrabano   +4 more
doaj   +1 more source

Adapting clinical guidelines to take account of multimorbidity [PDF]

, 2012
Most people with a chronic condition have multimorbidity, but clinical guidelines almost entirely focus on single conditions. It will never be possible to have good evidence for every possible combination of conditions, but guidelines could be made more ...
Alderson, P., Guthrie, B., McMurdo, M.E.T., Mercer, S.W., Payne, K.   +4 more
core   +1 more source

Expression of thrombospondin-4 in the infrapatellar fat pad and synovial fluid – potential contribution to osteoarthritis pain

Arthritis Research & Therapy
Background During osteoarthritis (OA) pathogenesis, the infrapatellar fat pad (IFP) undergoes fibrotic changes that might contribute to pain development.
Sebastian Braun, Patrizia Pollinger, Rebecca Sohn, Anna E. Rapp, Gundula Rösch, Frank Zaucke, Zsuzsa Jenei-Lanzl   +6 more
doaj   +1 more source

Evaluation of functional outcome and patient satisfaction after arthroscopic elbow arthrolysis [PDF]

, 2008
Arthroscopic arthrolysis is indicated for stiffness and pain caused by intrinsic stiffness and early arthritis of the elbow joint. Previous studies have demonstrated the benefits in relieving pain and improving motion, but none have reported the ...
Funk, L, Somanchi, BV
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