Results 1 to 10 of about 381,886 (148)
BMJ, 2006 Osteoarthritis is a leading cause of disability and source of societal cost in older adults. With an ageing and increasingly obese population, this syndrome is becoming even more prevalent than in previous decades.
D. Hunter, D. Felson
semanticscholar +7 more sources
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations
Cell, 2021 Summary Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated risk variants across 11 ...
Cindy G Boer +2 more
exaly +2 more sources
Fundamentals of Osteoarthritis: Inflammatory mediators in Osteoarthritis.
Osteoarthritis and Cartilage, 2023 As more has become known of the pathophysiology of osteoarthritis (OA), evidence that inflammation plays a critical role in its development and progression has accumulated. Here, we aim to review current knowledge of the complex inflammatory network in the OA joint.This narrative review is presented in three main sections: local inflammation, systemic ...
A. de Roover +3 more
semanticscholar +3 more sources
Nature Reviews Disease PrimersOsteoarthritis is a heterogeneous whole-joint disease that can cause pain and is a leading cause of disability and premature work loss. The predominant disease risk factors - obesity and joint injury - are well recognized and modifiable. A greater understanding of the complex mechanisms, including inflammatory, metabolic and post-traumatic processes ...
Sita M Bierma-Zeinstra +2 more
exaly +8 more sources
Nature Reviews Disease Primers, 2016 Osteoarthritis (OA) is the most common joint disorder, is associated with an increasing socioeconomic impact owing to the ageing population and mainly affects the diarthrodial joints. Primary OA results from a combination of risk factors, with increasing age and obesity being the most prominent.
Johanne, Martel-Pelletier +9 more
+8 more sources
The Lancet Rheumatology, 2023 Summary Background Osteoarthritis is the most common form of arthritis in adults, characterised by chronic pain and loss of mobility. Osteoarthritis most frequently occurs after age 40 years and prevalence increases steeply with age.
Jaimie D Steinmetz +166 more
semanticscholar +1 more source
Diagnosis and treatment of hip and knee osteoarthritis: A review
Journal of the American Medical Association (JAMA), 2021 Importance: Osteoarthritis (OA) affects more than 240 million people worldwide and is the most frequent reason for activity limitation in adults. This review focuses on hip and knee OA. Observations: OA is the most common type of arthritis.
J. Katz, Kaetlyn R. Arant, R. Loeser
semanticscholar +1 more source
Arthritis & Rheumatology, 2022 To estimate systematic and anatomic site–specific age‐standardized prevalence rates (ASRs) and analyze the secular trends of osteoarthritis (OA) at global, regional, and national levels.
Huibin Long +7 more
semanticscholar +1 more source
Arthritis care & research, 2020 To develop an evidence‐based guideline for the comprehensive management of osteoarthritis (OA) as a collaboration between the American College of Rheumatology (ACR) and the Arthritis Foundation, updating the 2012 ACR recommendations for the management of
S. Kolasinski +31 more
semanticscholar +1 more source
Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Signal Transduction and Targeted Therapy, 2023 Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects more than 500 million population worldwide. OA was believed to be caused by the wearing and tearing of articular cartilage, but it is now more commonly ...
Q. Yao +9 more
semanticscholar +1 more source