Results 1 to 10 of about 432,246 (250)

Assessing knee OA severity with CNN attention-based end-to-end architectures [PDF]

open access: yesProceedings of The 2nd International Conference on Medical Imaging with Deep Learning, PMLR 102:197-214, 2019, 2019
This work proposes a novel end-to-end convolutional neural network (CNN) architecture to automatically quantify the severity of knee osteoarthritis (OA) using X-Ray images, which incorporates trainable attention modules acting as unsupervised fine ...
Antony, Joseph   +4 more
core   +1 more source

Psychosocial and individual factors affecting Quality of Life (QoL) in patients suffering from Achilles tendinopathy: a systematic review

open access: yesBMC Musculoskeletal Disorders, 2022
Background Achilles tendinopathy (AT) is a joint condition that causes functional restrictions and pain. This condition negatively impacts patients' social connectedness and psychological well-being, reducing their quality of life (QoL). This review aims
Josep Verges   +5 more
doaj   +1 more source

Early detection of osteoarthritis in the rat with an antibody specific to type II collagen modified by reactive oxygen species

open access: yesArthritis Research & Therapy, 2021
Background Osteoarthritis (OA) is a disease of the whole joint, with articular cartilage breakdown as a major characteristic. Inflammatory mediators, proteases, and oxidants produced by chondrocytes are known to be responsible for driving cartilage ...
Anne Gigout   +6 more
doaj   +1 more source

SYSADOAs: do their origin and quality make a difference in efficacy and safety?

open access: yesGlobal Rheumatology, 2021
Symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) comprise a heterogeneous group of drugs with a long-term effect on the symptoms of osteoarthritis.
Marianna Vitaloni   +2 more
doaj   +1 more source

Common Biochemical and Magnetic Resonance Imaging Biomarkers of Early Knee Osteoarthritis and of Exercise/Training in Athletes: A Narrative Review

open access: yesDiagnostics, 2021
Knee osteoarthritis (OA) is the most common joint disease of the world population. Although considered a disease of old age, OA also affects young individuals and, more specifically among them, those practicing knee-joint-loading sports. Predicting OA at
Johanne Martel-Pelletier   +3 more
doaj   +1 more source

Prokineticin 2 is a catabolic regulator of osteoarthritic cartilage destruction in mouse

open access: yesArthritis Research & Therapy, 2023
Background Our preliminary study indicates that the multi-functional protein, prokineticin 2 (Prok2), is upregulated in osteoarthritic (OA) chondrocytes as a target of the hypoxia-inducible factor (HIF)-2α.
Jiye Yang   +4 more
doaj   +1 more source

Therapeutic Effect of Exosomes Derived From Stem Cells in Spinal Cord Injury: A Systematic Review Based on Animal Studies

open access: yesFrontiers in Neurology, 2022
ObjectiveA systematic review of the role of stem cell-derived exosomes in repairing spinal cord injury (SCI) and the existing problems in animal experiments to provide a reference for better animal experiments and clinical studies in the future ...
Cangyu Zhang   +14 more
doaj   +1 more source

In silico targeting of interleukin-6 by natural compounds

open access: yesBangladesh Journal of Pharmacology, 2014
Rheumatoid arthritis an autoimmune disorder affecting many tissues and organs, is a challenging prospect in terms of treatment. Our work is looking into finding lead compound of natural origin against IL-6, an important cyto-kine having a profound role ...
Wei Zhou   +4 more
doaj   +1 more source

Two or four injections of platelet-rich plasma for osteoarthritic knee did not change synovial biomarkers but similarly improved clinical outcomes

open access: yesScientific Reports, 2021
We compared two and four intra-articular injections of platelet-rich plasma (PRP) in terms of changes of synovial cytokines and clinical outcomes. One hundred twenty-five patients having knee osteoarthritis (OA) underwent PRP injections at a 6-week ...
Srihatach Ngarmukos   +11 more
doaj   +1 more source

Association of malalignment, muscular dysfunction, proprioception, laxity and abnormal joint loading with tibiofemoral knee osteoarthritis - a systematic review and meta-analysis [PDF]

open access: yes, 2018
Background: To investigate (1) the association of specific biomechanical factors with knee osteoarthritis and knee osteoarthritis development, and (2) the impact of other relevant risk factors on this association.Methods: MEDLINE, EMBASE, CINAHL and ...
Dekker, Joost   +6 more
core   +4 more sources

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