Results 1 to 10 of about 445,630 (327)

Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Signal Transduction and Targeted Therapy, 2023
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects more than 500 million population worldwide. OA was believed to be caused by the wearing and tearing of articular cartilage, but it is now more commonly ...
Q. Yao, Xiaohao Wu, Chu Tao, Weiyuan Gong, Mingjue Chen, Minghao Qu, Yiming Zhong, Tailin He, Sheng Chen, G. Xiao   +9 more
semanticscholar   +1 more source

Prevalence Trends of Site‐Specific Osteoarthritis From 1990 to 2019: Findings From the Global Burden of Disease Study 2019

Arthritis & Rheumatology, 2022
To estimate systematic and anatomic site–specific age‐standardized prevalence rates (ASRs) and analyze the secular trends of osteoarthritis (OA) at global, regional, and national levels.
Huibin Long, Qiang Liu, Heyong Yin, Kai Wang, Naicheng Diao, Yuqing Zhang, Jianhao Lin, A. Guo   +7 more
semanticscholar   +1 more source

Diagnosis and Treatment of Hip and Knee Osteoarthritis: A Review.

Journal of the American Medical Association (JAMA), 2021
Importance Osteoarthritis (OA) is the most common joint disease, affecting an estimated more than 240 million people worldwide, including an estimated more than 32 million in the US.
J. Katz, Kaetlyn R. Arant, R. Loeser
semanticscholar   +1 more source

Psychosocial and individual factors affecting Quality of Life (QoL) in patients suffering from Achilles tendinopathy: a systematic review

BMC Musculoskeletal Disorders, 2022
Background Achilles tendinopathy (AT) is a joint condition that causes functional restrictions and pain. This condition negatively impacts patients' social connectedness and psychological well-being, reducing their quality of life (QoL). This review aims
Josep Verges, Nina Martínez, Aina Pascual, Marco Bibas, Manel Santiña, Gil Rodas   +5 more
doaj   +1 more source

Dynamic weight-bearing test during jumping: A sensitive outcome measure of chronic osteoarthritis pain in rats

Heliyon, 2021
Pain due to osteoarthritis (OA) often occurs during locomotion in the vertical direction when joints are subjected to high mechanical load, e.g. during standing up from a chair or using stairs.
Andreas Westhof, Kerstin Kleinschmidt-Doerr, Martin Michaelis, Christian Brenneis   +3 more
doaj   +1 more source

Early detection of osteoarthritis in the rat with an antibody specific to type II collagen modified by reactive oxygen species

Arthritis Research & Therapy, 2021
Background Osteoarthritis (OA) is a disease of the whole joint, with articular cartilage breakdown as a major characteristic. Inflammatory mediators, proteases, and oxidants produced by chondrocytes are known to be responsible for driving cartilage ...
Anne Gigout, Donata Harazin, Louise M. Topping, Didier Merciris, Sven Lindemann, Christian Brenneis, Ahuva Nissim   +6 more
doaj   +1 more source

Obesity, Inflammation, and Immune System in Osteoarthritis

Frontiers in Immunology, 2022
Obesity remains the most important risk factor for the incidence and progression of osteoarthritis (OA). The leading cause of OA was believed to be overloading the joints due to excess weight which in turn leads to the destruction of articular cartilage.
Udhaya Nedunchezhiyan, I. Varughese, A. Sun, Xiaoxin Wu, R. Crawford, I. Prasadam   +5 more
semanticscholar   +1 more source

2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee

Arthritis care & research, 2020
To develop an evidence‐based guideline for the comprehensive management of osteoarthritis (OA) as a collaboration between the American College of Rheumatology (ACR) and the Arthritis Foundation, updating the 2012 ACR recommendations for the management of
S. Kolasinski, T. Neogi, M. Hochberg, C. Oatis, G. Guyatt, J. Block, L. Callahan, Cindy Copenhaver, Carole V Dodge, D. Felson, Kathleen Gellar, W. Harvey, G. Hawker, Edward Herzig, C. Kwoh, A. Nelson, J. Samuels, C. Scanzello, D. White, B. Wise, R. Altman, D. DiRenzo, J. Fontanarosa, Gina Giradi, Mariko L. Ishimori, D. Misra, A. A. Shah, A. Shmagel, L. Thoma, Marat Turgunbaev, Amy S. Turner, J. Reston   +31 more
semanticscholar   +1 more source

SYSADOAs: do their origin and quality make a difference in efficacy and safety?

Global Rheumatology, 2021
Symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) comprise a heterogeneous group of drugs with a long-term effect on the symptoms of osteoarthritis.
Marianna Vitaloni, Ingrid Möller, Josep Verges   +2 more
doaj   +1 more source

AAOS Clinical Practice Guideline Summary: Management of Osteoarthritis of the Knee (Nonarthroplasty), Third Edition.

Journal of the American Academy of Orthopaedic Surgeons, 2022
Management of Osteoarthritis of the Knee (nonarthroplasty) Evidence-Based Clinical Practice Guideline is based on a systematic review of published studies for the nonarthroplasty treatment of osteoarthritis of the knee in adults (ages 17 years and older).
R. Brophy, Yale A. Fillingham
semanticscholar   +1 more source