Results 51 to 60 of about 432,246 (250)

Coherence Learning using Keypoint-based Pooling Network for Accurately Assessing Radiographic Knee Osteoarthritis [PDF]

arXiv, 2021
Knee osteoarthritis (OA) is a common degenerate joint disorder that affects a large population of elderly people worldwide. Accurate radiographic assessment of knee OA severity plays a critical role in chronic patient management. Current clinically-adopted knee OA grading systems are observer subjective and suffer from inter-rater disagreements.
arxiv  

Health-related quality of life and flourishing in current and former recreational and elite cricketers

Health and Quality of Life Outcomes, 2020
Background Health related quality of life (HRQoL) and flourishing are constructs that encompasses a holistic representation of physical, psychological, and social health.
Garrett S. Bullock, Gary S. Collins, Nick Peirce, Nigel K. Arden, Stephanie R. Filbay   +4 more
doaj   +1 more source

The n-acetyl phenylalanine glucosamine derivative attenuates the inflammatory/catabolic environment in a chondrocyte-synoviocyte co-culture system [PDF]

, 2019
Osteoarthritis (OA), the most prevalent degenerative joint disease, still lacks a true disease-modifying therapy. The involvement of the NF-κB pathway and its upstream activating kinases in OA pathogenesis has been recognized for many years.
Borzi, R. M., Fini, M., Minguzzi, M., Pagani, S., Santi, S., Scotto D'Abusco, A., Sicuro, L., Veronesi, F.   +7 more
core   +1 more source

A Lightweight CNN and Joint Shape-Joint Space (JS2) Descriptor for Radiological Osteoarthritis Detection [PDF]

arXiv, 2020
Knee osteoarthritis (OA) is very common progressive and degenerative musculoskeletal disease worldwide creates a heavy burden on patients with reduced quality of life and also on society due to financial impact. Therefore, any attempt to reduce the burden of the disease could help both patients and society.
arxiv  

Upregulated endonuclease Regnase-1 suppresses osteoarthritis by forming a negative feedback loop of catabolic signaling in chondrocytes

Arthritis Research & Therapy, 2021
Background Ribonucleases (RNases) play central roles in the post-transcriptional regulation of mRNA stability. Our preliminary results revealed that the endonuclease Regnase-1 is specifically upregulated in osteoarthritic chondrocytes. We herein explored
Jeong-In Yang, Jang-Soo Chun
doaj   +1 more source

Aging, osteoarthritis and transforming growth factor-beta signaling in cartilage. [PDF]

, 2006
Osteoarthritis is a common malady of the musculoskeletal system affecting the articular cartilage. The increased frequency of osteoarthritis with aging indicates the complex etiology of this disease, which includes pathophysiology and joint stability ...
Reddi, A Hari
core   +1 more source

Efficacy and safety of the long-term oral administration of carprofen in the treatment of osteoarthritis in dogs [PDF]

, 2007
The aim of this study conducted in France was to confirm the efficacy and safety of the oral administration of carprofen (Rimadyl®) at 4 mg/kg once a day during four months in the treatment of clinically chronic osteoarthritis in dogs.
Autefage, André, Gosselin, Jacques
core  

Non-Invasive Mouse Models of Post-Traumatic Osteoarthritis [PDF]

, 2015
SummaryAnimal models of osteoarthritis (OA) are essential tools for investigating the development of the disease on a more rapid timeline than human OA.
A.A. Pitsillides, Anderson, Armstrong, B.A. Christiansen, Batiste, Borella, Boyd, Brandt, Brodt, Brown, Carames, Chateauvert, Chateauvert, Chou, Christiansen, Christiansen, Chu, Crowninshield, D.R. Haudenschild, Das-Gupta, De Souza, De Souza, Diekman, Dirschl, Dunham, F. Guilak, Felson, Fitzgerald, Frankl, Funakoshi, Furman, Furman, Glasson, Guilak, Guingamp, Hashimoto, Hayami, Herzog, Holguin, Hui, Inoue, Jimenez, Jimenez, Jones, K.A. Lockwood, Kamekura, Karahan, Killian, Kimmerling, Ko, L.J. Sandell, Lewis, Lewis, Li, Little, Lockwood, Lodewyckx, Lohmander, Louer, Lynch, M.C.H. van der Meulen, M.J. Silva, Ma, Malfait, Malfait, Marcelon, Marsh, Marshall, Meacock, Messner, Moodie, Noyes, Oiestad, Onur, Palmoski, Palmoski, Pastoureau, Pond, Pottenger, Poulet, Poulet, Poulet, Roudier, S.A. Olson, Satkunananthan, Seifer, Shapiro, Suzuki, Teeple, Tiraloche, van Beuningen, van Beuningen, van Beuningen, van der Kraan, van der Kraan, van Osch, van Osch, van Osch, Wancket, Ward, Williams, Wong, Wu, Wu, Yang, Zaman, Zhou   +106 more
core   +1 more source

Osteoarthritis [PDF]

Current Opinion in Rheumatology, 2007
AbstractOsteoarthritis (OA) is characterized by degeneration of articular cartilage, limited intraarticular inflammation with synovitis, and changes in peri‐articular and subchondral bone. Multiple factors are involved in the pathogenesis of OA, including mechanical influences, the effects of aging on cartilage matrix composition and structure, and ...
Mary B, Goldring, Steven R, Goldring
openaire   +4 more sources

Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth

Nature Communications, 2022
The study shows that mechanical forces trigger secretion of the extracellular matrix protein dentin matrix protein 1 from osteoblasts. This transforms bone growth-promoting blood vessels into a quiescent subtype to limit bone growth at the end of ...
Maria Dzamukova, Tobias M. Brunner, Jadwiga Miotla-Zarebska, Frederik Heinrich, Laura Brylka, Mir-Farzin Mashreghi, Anjali Kusumbe, Ralf Kühn, Thorsten Schinke, Tonia L. Vincent, Max Löhning   +10 more
doaj   +1 more source