Results 191 to 200 of about 942,824 (250)

Inhibition of endolysosomal two-pore channel 2 (TPC2) induces osteoblast differentiation and matrix mineralization while targeting autophagy. [PDF]

J Endocrinol Invest
Montaseri A, Rossi M, Battafarano G, Riccioli A, Palombi F, Giampietri C, Liguoro D, Mancini R, Meucci M, Palmisano B, Riminucci M, Keller M, Bracher F, Grimm C, Umehara K, De-Eknamkul W, Filippini A, Del Fattore A.   +17 more
europepmc   +1 more source

Serum osteocalcin is associated with scintigraphic abnormalities in lame and clinically sound racehorses

Equine Veterinary Journal, EarlyView.
Abstract Background Musculoskeletal injury is a major welfare and economic challenge in racehorses, with stress‐related bone injury contributing to training interruption and catastrophic failure. Advanced imaging modalities can detect early skeletal pathology but remain limited in routine screening environments.
Peter Tually, Dominique Blache, Jack Meadows, Shiphrah Tagore, Paul O'Callaghan, Matilda Hathway, Ian Fulton, Geoffrey Currie   +7 more
wiley   +1 more source

Soluble Nanomedicine Against Soluble Neurosensitizers to Effectively Relieve Osteoarthritis Pain and Joint Damage

Exploration, EarlyView.
Osteoarthritis pain arises not only from joint damage but also from inflammation, abnormal bone changes, and excessive nerve activation inside the joint. In this study, we developed an injectable nanomedicine, LAC, that responds to the acidic environment of osteoarthritic joints to locally release two approved drugs, reducing inflammation, limiting ...
Junyan Liu, Feixiang Ding, Jiayi Li, Min Liu, Lingyu Su, Zixi Wang, Congying Pi, Shilong Jiang, Zhaokui Zeng, Changjun Li, Chao Zeng, Guanghua Lei, Kelong Ai   +12 more
wiley   +1 more source

β-Catenin: A Key Molecule in Osteoblast Differentiation. [PDF]

Biomolecules
Wróbel E, Wojdasiewicz P, Mikulska A, Szukiewicz D.   +3 more
europepmc   +1 more source

Untethered Electrical Stimulation Using Optoelectricity and Piezoelectricity for Tissue Regeneration

FlexTech, EarlyView.
Untethered electrical stimulation from optoelectronic and piezoelectric materials can aid regeneration of damaged tissue. ABSTRACT Electrical signals are increasingly recognized as important regulators of tissue development and regeneration, with outcomes linked to behaviors including proliferation, differentiation, cell migration, and more.
Ryan Yao, Baochun Xu, Cunjiang Yu
wiley   +1 more source

Murine model of high bone mass osteogenesis imperfecta exhibits bone matrix hyper-mineralization, misaligned mineral crystals, and altered osteoblast differentiation. [PDF]

Bone Res
Barnes AM, Rajpar MH, Perosky JE, Blouin S, Khoury B, Weis M, Hefferan T, Derkyi A, Guterman-Ram G, Hedjazi G, Campbell K, Stephan C, Eyre DR, Dale RK, Fratzl P, Kozloff KM, Fratzl-Zelman N, Marini JC.   +17 more
europepmc   +1 more source

Viability of Tumor Cells in Bone Dust: Implications for Oncologic Skull Base Surgery

Head &Neck, EarlyView.
ABSTRACT Background Head and neck tumors with skull base involvement may require drilling of tumor infiltrated bone. We hypothesize that bone dust generated during this process contains viable tumor cells that may seed the surgical field. Methods Tumors with gross bone invasion were drilled, and dust was collected for H&E, cell viability analysis, and ...
Kelly Bridgham, Hani Samarah, Emma De Ravin, Hannah Kenny, Eric Mastrolonardo, Annie Moroco, Suhao Han, Oliver Abinader, Ramkrishna Mitra, Alban Linnenbach, Gurston Nyquist, Christopher Farrell, Stacey Gargano, Andrew P. South, Adam Luginbuhl   +14 more
wiley   +1 more source

Interactions Between HEP Peptide and EGFR Involved in the Osteoblast Differentiation. [PDF]

Foods
Gan J, Huang Y, Jian M, Chen Y, Jiang Y, Qiao Y, Li Y.   +6 more
europepmc   +1 more source

Engineered 3D cultured human nasal mucosa mesenchymal stem cell derived sEVs for targeted brain‐derived neurotrophic factor delivery to enhance neurogenesis and attenuate brain damage

Interdisciplinary Medicine, EarlyView.
This study successfully developed and evaluated BDNF@RVG‐sEVs, a novel brain‐targeted nanomedicine based on hnmMSC‐derived sEVs, designed to overcome the BBB and enhance neurorestoration. By integrating RVG for enhanced brain targeting and encapsulating BDNF for potent neurorepair, our system address the key limitations of the conventional sEVs and ...
Xueting Wang, Junge Chen, Jiao Xia, Weitong Yang, Teng Ma, Tianzi Shan, Weifeng He, Gaoman Zhang, Zhuoran Xia, Weiwei Wang, Zhusheng Liu, Zhiqiang Yi, Piye Niu, Tian Chen   +13 more
wiley   +1 more source

Knockdown of GCNT2 promoted osteoblast differentiation by activating PI3K/AKT/mTOR pathway in osteoblasts. [PDF]

Sci Rep
Huang Y, Wang S, Hu D, Zhang L, Shi S.
europepmc   +1 more source