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Osteoblast and chondroblast differentiation
Bone, 1995Recognition of discrete commitment and differentiation stages requires characterization of changes in proliferative capacity together with the temporal acquisition or loss of expression of molecular and morphological traits. Both cell lines and primary cultures have been useful for analysis of transitional steps in the chondroblast (CB) and osteoblast (
J E, Aubin +3 more
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Osteoblastic cells: Differentiation and trans-differentiation
Archives of Biochemistry and Biophysics, 2008The osteoblast is the bone forming cell and is derived from mesenchymal stem cells (MSC) present among the bone marrow stroma. MSC are capable of multi-lineage differentiation into mesoderm-type cells such as osteoblasts and adipocytes. Understanding the mechanisms underlying osteoblast differentiation from MSC is a central topic in bone biology that ...
Kassem, Moustapha +2 more
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Regulation of Osteoblast Differentiation by Slit2 in Osteoblastic Cells
Cells Tissues Organs, 2008<i>Background/Aims:</i> There is an urgent need to identify the molecular factors involved in osteoblast proliferation and differentiation in order to improve bone formation and treat bone disease. Recent studies demonstrate that many ‘axon guidance’ molecules play important roles in the development and remodeling of bone through their ...
Hongli, Sun +3 more
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MEK5 suppresses osteoblastic differentiation
Biochemical and Biophysical Research Communications, 2015Extracellular signal-regulated kinase 5 (ERK5) is a member of the mitogen-activated protein kinase (MAPK) family and is activated by its upstream kinase, MAPK kinase 5 (MEK5), which is a member of the MEK family. Although the role of MEK5 has been investigated in several fields, little is known about its role in osteoblastic differentiation.
Shoichi, Kaneshiro +4 more
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Proteomic profiling of differentiating osteoblasts
Expert Review of Proteomics, 2006The major event that triggers osteogenesis is the transition of mesenchymal stem cells into bone-forming, differentiating osteoblast cells. Osteoblast differentiation is the primary event of bone formation, exemplified by the synthesis, deposition and mineralization of extracellular matrix. Osteoblast differentiation is controlled tightly by sequential
Josip, Blonder +2 more
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PKCα suppresses osteoblastic differentiation
Bone, 2011Protein kinase C (PKC) plays an essential role in cellular signal transduction for mediating a variety of biological functions. There are 11 PKC isoforms and these isoforms are believed to play distinct roles in cells. Although the role of individual isoforms of PKC has been investigated in many fields, little is known about the role of PKC in ...
Akio, Nakura +3 more
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Insulin facilitates osteoblast differentiation
Cell Biology International, 2013AbstractTissue engineering of bone has been increasingly used in the bone defect repair. To generate osteoblasts is a major approach, and here we have examined ways of improving the efficiency of producing osteoblasts. Adipose stem cells (ADSC) were prepared from rat mesentery tissue, and transfected with Cbfa1 gene vector or/and IGF‐1R gene vector ...
Lin, Wang +4 more
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Differentiation of Osteoblasts on Pectin-Coated Titanium
Biomacromolecules, 2008The gold standard for implant metals is titanium, and coatings such as collagen-I, RGD-peptide, chondroitin sulfate, and calcium phosphate have been used to modify its biocompatibility. We investigated how titanium coated with pectins, adaptable bioactive plant polysaccharides with anti-inflammatory effects, supports osteoblast differentiation.
Kokkonen, H. +5 more
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Osteosarcoma and Osteoblastic Differentiation
Clinical Orthopaedics and Related Research, 2007In addition to changes in cellular pathways, loss of differentiation is a notable feature of osteosarcoma. We hypothesized that blocks to normal differentiation may be a common feature of osteosarcoma, and may be one of many critical events that occur during oncogenesis in osteosarcoma.
Rex C, Haydon +2 more
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Regulation of Runx2 by MicroRNAs in osteoblast differentiation
Life Sciences, 2019Bone is one of the most dynamic organs in the body that continuously undergoes remodeling through bone formation and resorption. A cascade of molecules and pathways results in the osteoblast differentiation that is attributed to osteogenesis, or bone formation. The process of osteogenesis is achieved through participation of the Wnt pathway, FGFs, BMPs/
Akshaya, Narayanan +3 more
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