Results 231 to 240 of about 71,796 (264)

Inorganic Polyphosphate Induces Osteoblastic Differentiation

Journal of Dental Research, 2010
Inorganic polyphosphate [Poly(P)] is especially prevalent in osteoblasts. We tested the hypothesis that Poly(P) stimulates osteoblastic differentiation and polyphosphate metabolism for bone formation. The osteoblast-like cell line, MC 3T3-E1, was cultured with Poly(P), and gene expression was evaluated by real-time reverse-transcription polymerase ...
Y, Usui, T, Uematsu, T, Uchihashi, M, Takahashi, M, Takahashi, M, Ishizuka, R, Doto, H, Tanaka, Y, Komazaki, M, Osawa, K, Yamada, M, Yamaoka, K, Furusawa   +12 more
openaire   +2 more sources

The role of PPARγ for the osteoblastic differentiation.

Journal of endocrinological investigation, 2010
Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated transcription factor that belongs to the nuclear hormone receptor superfamily and functions as a heterodimer with a retinoid X receptor by binding to PPAR responsive elements. PPARγ plays an important role in adipocyte differentiation and is activated by long-chain fatty acid ...
Viccica, G, Francucci, C. M, MARCOCCI, CLAUDIO   +2 more
openaire   +3 more sources

Osteoblastic differentiation.

Ciba Foundation symposium, 1989
The fully differentiated osteoblast may be easily recognized in bone tissue. Its cuboidal shape, its position directly opposed to the bone surface and its capacity to produce calcified bone matrix are characteristic. Three other differentiation stages are also reasonably well defined--the preosteoblast, the osteocyte and the lining cell.
P J, Nijweide, A, van der Plas, A A, Olthof   +2 more
openaire   +1 more source

Osteoblasts: Differentiation and Function

1993
Cells of the osteoblast lineage occupy a central position in bone metabolism. The formation of a structurally sound skeleton, with its strength and integrity conserved by constant remodeling, and the formation as well as activation of the major bone-resorbing cell, the osteoclast, are the result of direct and indirect influences of osteoblasts.
T. J. Martin, D. M. Findlay, J. K. Heath, K. W. Ng   +3 more
openaire   +1 more source

Dioxins interfere with differentiation of osteoblasts and osteoclasts

Bone, 2009
We have previously shown that the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) affects bone growth, modelling and mechanical strength in vivo. In this study, we utilized differentiation of bone marrow stem cells to osteoblasts and osteoclasts as a model system to study the effects of TCDD on bones.
Merja, Korkalainen, Elise, Kallio, Anu, Olkku, Katri, Nelo, Joanna, Ilvesaro, Juha, Tuukkanen, Anitta, Mahonen, Matti, Viluksela   +7 more
openaire   +2 more sources

Transcriptional control of osteoblast growth and differentiation

Physiological Reviews, 1996
Osteoblast differentiation is a multistep series of events modulated by an integrated cascade of gene expression that initially supports proliferation and the sequential expression of genes associated with the biosynthesis, organization, and mineralization of the bone extracellular matrix.
Stein, Gary S., Lian, Jane B., Stein, Janet L., Van Wijnen, Andre J., Montecino, Martin A.   +4 more
openaire   +3 more sources

Regulation of Osteoblast Differentiation by Runx2

2009
Runx2 protein is first detected in preosteoblasts, and the expression is upregulated in immature osteoblasts, but downregulated in mature osteoblasts. Runx2 is the first transcription factor required for determination of the osteoblast lineage, while Sp7 and canonical Wnt-signaling further direct the fate of mesenchymal cells to osteoblasts, blocking ...
openaire   +2 more sources

Regulatory mechanisms of osteoblast and osteoclast differentiation

Oral Diseases, 2002
Bone is continuously destroyed and reformed to maintain constant bone volume and calcium homeostasis in vertebrates throughout their lives. Osteoblasts and osteoclasts are specialized cells responsible for bone formation and resorption, respectively.
T, Katagiri, N, Takahashi
openaire   +2 more sources

Transcriptional profiling of human osteoblast differentiation

Journal of Cellular Biochemistry, 2003
AbstractOsteoblast differentiation is a key aspect of bone formation and remodeling. To further our understanding of the differentiation process, we have developed a collection of conditionally immortalized adult human osteoblast cell lines representing discrete stages of differentiation.
J, Billiard, R A, Moran, M Z, Whitley, M, Chatterjee-Kishore, K, Gillis, E L, Brown, B S, Komm, P V N, Bodine   +7 more
openaire   +2 more sources

Osteoblast and Osteoclast Differentiation in Modeled Microgravity

Annals of the New York Academy of Sciences, 2007
Abstract:  Prolonged microgravity experienced by astronauts is associated with a decrease in bone mineral density. To investigate the effect of microgravity on differentiation of osteoclasts and osteoblasts, we used a NASA‐recommended, ground‐based, microgravity‐simulating system, the Rotary Cell Culture System (RCCS).
Ritu, Saxena, George, Pan, Jay M, McDonald   +2 more
openaire   +2 more sources