Results 181 to 190 of about 18,733 (222)
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Stimulation of Osteoblastic Bone Metastasis by Canine Prostate Cancer
The FASEB Journal, 2022Prostate cancer metastases primarily localize in the bone where they induce a unique osteoblastic response. The mechanisms are not well understood; however, they depend on a complex interplay between prostate cancer cells and the cellular microenvironment in the bone marrow.
Shiyu Yuan +3 more
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Osteoblastic Bone Metastasis in Zollinger-Ellison Syndrome
Radiology, 1976The authors describe a case of osteoblastic metastasis in a patient with Zollinger-Ellison syndrome resulting from the presence of a pancreatic tumor, which they believe is the first such case documented. Following a total gastectomy for hyperacidity in a 53-year-old woman, a gradually enlarging liver was treated with steptozotocin.
R T, Pederson +4 more
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Osteoblasts in prostate cancer metastasis to bone
Nature Reviews Cancer, 2005Metastasis to bone is common in lung, kidney, breast and prostate cancers. However, prostate cancer is unique in that bone is often the only clinically detectable site of metastasis, and the resulting tumours tend to be osteoblastic (bone forming) rather than osteolytic (bone lysing). The interaction between host cells and metastatic cancer cells is an
Christopher J, Logothetis, Sue-Hwa, Lin
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[Mechanism of osteoblastic bone metastasis of prostate cancer].
Clinical calcium, 2006The high prevalence of osteoblastic bone metastasis in prostate cancer is thought to be attributable to the production of osteoblast-stimulating factors by prostate cancer cells. Prostate-specific antigen (PSA) expression is arguably the most distinctive features of prostate cancer.
Hiroyuki, Yonou +2 more
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European Radiology, 2023
To investigate measurements derived from plain and enhanced spectral CT in differentiating osteoblastic bone metastasis (OBM) from bone island (BI).From January to November 2020, 73 newly diagnosed cancer patients with 201 bone lesions (OBM = 92, BI = 109) having received spectral CT were retrospectively enrolled. Measurements including CT values of 40-
Honghong Luo +8 more
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To investigate measurements derived from plain and enhanced spectral CT in differentiating osteoblastic bone metastasis (OBM) from bone island (BI).From January to November 2020, 73 newly diagnosed cancer patients with 201 bone lesions (OBM = 92, BI = 109) having received spectral CT were retrospectively enrolled. Measurements including CT values of 40-
Honghong Luo +8 more
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Pancreatic cancer's initial presentation: back pain due to osteoblastic bone metastasis
European Journal of Cancer Care, 2010Pancreatic cancer may cause osteolytic metastases, but the osteoblastic ones are extremely rare. In addition, it almost always presents with symptoms related to the invasion of the structures in the abdomen. Symptoms from bone metastases are rare and, if seen, are in the late phase of the course. We present a case of cancer of the body of the pancreas,
S G, Pneumaticos +3 more
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Cell Research, 2023
Estrogen receptor (ER)-positive luminal breast cancer is a subtype with generally lower risk of metastasis to most distant organs. However, bone recurrence occurs preferentially in luminal breast cancer. The mechanisms of this subtype-specific organotropism remain elusive.
Qiuyao Wu +16 more
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Estrogen receptor (ER)-positive luminal breast cancer is a subtype with generally lower risk of metastasis to most distant organs. However, bone recurrence occurs preferentially in luminal breast cancer. The mechanisms of this subtype-specific organotropism remain elusive.
Qiuyao Wu +16 more
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Seminars in Cancer Biology, 2021
In this review we highlighted the newest aspects concerning the physiopathology of breast cancer metastatization into the bone including: a) in situ biomarkers of breast cancer metastatic diseases, b) biological processes related to the origin of metastatic cells (epithelial to mesenchymal transition), c) the nature and the possible role of Breast ...
Scimeca, Manuel +6 more
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In this review we highlighted the newest aspects concerning the physiopathology of breast cancer metastatization into the bone including: a) in situ biomarkers of breast cancer metastatic diseases, b) biological processes related to the origin of metastatic cells (epithelial to mesenchymal transition), c) the nature and the possible role of Breast ...
Scimeca, Manuel +6 more
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Breast Cancer Metastasis to Bone Affects Osteoblast Differentiation
2003Abstract : Breast cancer fatally metastasizes to bone and activates osteoclasts, cells that resorb bone, resulting in the formation of osteolytic lesions. Certain drugs, bisphosphonates, slow the action of osteoclasts, however, the bone lesions are not repaired.
Andrea M. Mastro, Robyn R. Mercer
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Role of prostaglandin E produced by osteoblasts in osteolysis due to bone metastasis
Biochemical and Biophysical Research Communications, 2003Prostaglandin E2 (PGE2) is produced in bone mainly by osteoblasts and stimulates bone resorption. Osteolytic bone metastasis of cancers is accompanied by bone resorption. In this study, we examined the roles of PGE2 in osteolysis due to bone metastasis of breast cancer. Injection of human breast cancer cells, MDA-MB-231 (MDA-231), into nude mice causes
Tomoyasu, Ohshiba +2 more
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