Results 91 to 100 of about 81,269 (285)

Temperature responsiveness of gilthead sea bream bone; an in vitro and in vivo approach [PDF]

, 2018
This study aimed to characterize the molecules involved in osteogenesis in seabream and establish using in vitro/in vivo approaches the responsiveness of selected key genes to temperature.
Capilla, Encarnacion, Costa, Rita, Gisbert, Enric, Gutierrez, Joaquim, Martins, Rute, Navarro, Isabel, Patricia Mateus, Ana, Power, Deborah M., Riera-Heredia, Natalia   +8 more
core   +3 more sources

Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration

Advanced Science, EarlyView.
Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman, Carla Alvarez Rivas, Aashish Srivastava, Nora Marek, Kamal Mustafa, Alpdogan Kantarci   +5 more
wiley   +1 more source

Effects of eluted components from 4-META/MMA-TBB adhesive resin sealer on osteoblastic cell proliferation

Journal of Dental Sciences, 2012
Background/purpose: Adhesive resin sealer systems are applied to seal root-canal systems more effectively through the formation of a resin impregnation layer.
Aya Kawasaki, Yoshihiko Hayashi, Kajiro Yanagiguchi, Shizuka Yamada, Minoru Syudo, Kazunari Igawa, Takeshi Ikeda, Shisei Kubo, Mamoru Fujiwara   +8 more
doaj   +1 more source

Vinpocetine Attenuates the Osteoblastic Differentiation of Vascular Smooth Muscle Cells. [PDF]

PLoS ONE, 2016
Vascular calcification is an active process of osteoblastic differentiation of vascular smooth muscle cells; however, its definite mechanism remains unknown.
Yun-Yun Ma, Lin Sun, Xiu-Juan Chen, Na Wang, Peng-Fei Yi, Min Song, Bo Zhang, Yu-Zhong Wang, Qiu-Hua Liang   +8 more
doaj   +1 more source

A Dual‐Responsive Versatile Nanohybrid Orchestrating Tumor Elimination and Tumor‐Associated Osteolysis Restoration via Sequential Release

Advanced Science, EarlyView.
The versatile CaO2@CuMOF@HAP nanohybrid demonstrates an outstanding MMP9/pH‐triggered release performance for sequential release of osteogenic growth peptide into deep‐seated tumor‐infiltrated bone destruction areas and dual ions into tumor cells, enabling efficient tumor‐associated osteolysis restoration and tumor elimination for more comprehensive ...
Lan Liu, Han‐Zhe Liu, Zhe‐Nan Liu, Tong Wang, Li‐Li Yu, Qiu‐Jing Li, Zi‐Yi Chen, Guo‐Feng Luo, Zheng‐Jun Shang   +8 more
wiley   +1 more source

Icariin, but Not Genistein, Exerts Osteogenic and Anti-apoptotic Effects in Osteoblastic Cells by Selective Activation of Non-genomic ERα Signaling

Frontiers in Pharmacology, 2018
Genistein and icariin are flavonoid compounds that exhibit estrogen-like properties in inducing bone formation and reducing bone loss associated with estrogen deficiency in both preclinical and clinical studies.
Ming-Xian Ho, Christina C.-W. Poon, Ka-Chun Wong, Zuo-Cheng Qiu, Zuo-Cheng Qiu, Zuo-Cheng Qiu, Man-Sau Wong, Man-Sau Wong, Man-Sau Wong   +8 more
doaj   +1 more source

Identification of a Force‐Induced Sox9+Acan+ Transitional Subpopulation Linked to FGF2–FGFR2–ERK Signaling in Orthodontic Bone Remodeling

Advanced Science, EarlyView.
Mechanical loading induces a previously unrecognized Sox9+Acan+ transitional mesenchymal cell population in the periodontal ligament that promotes osteoclastogenesis via the FGF2–FGFR2–ERK axis. Targeting this mechanoresponsive stromal population using a localized GelMA@siRNA delivery strategy attenuates pathological osteoclast overactivation and root ...
Miao Tan, Minyu He, Mingrui Zong, Qiya Tang, Yinan Liu, Jiaju Deng, Shun Huang, Xiaoxiao Lei, Jie Li, Lan Huang   +9 more
wiley   +1 more source

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

Physical activity and hypocaloric diet recovers osteoblasts homeostasis in women affected by abdominal obesity. [PDF]

, 2016
Obesity is a multifactorial disease linked to metabolic chronic disorders such as diabetes, and hypertension. Also, it has recently been associated with skeletal alterations and low bone mineral density.
Baldari, C, Bimonte, VIVIANA MARIA, Di Luigi, L, Donini, Lorenzo Maria, Emerenziani, GIAN PIETRO, Fittipaldi, Simona, Fornari, Rachele, Greco, Ea, Guidetti, L, Lenzi, Andrea, Marocco, Chiara, Migliaccio, S., Nicolai, E, Poggiogalle, Eleonora   +13 more
core   +1 more source

Extracellular vesicle microRNAs contribute to the osteogenic inhibition of mesenchymal stem cells in multiple myeloma [PDF]

, 2020
Osteolytic bone disease is the major complication associated with the progression of multiple myeloma (MM). Recently, extracellular vesicles (EVs) have emerged as mediators of MM-associated bone disease by inhibiting the osteogenic differentiation of ...
Alessandro R., Carlisi M., Conigliaro A., De Luca A., Giavaresi G., Lo Bosco G., Parisi S., Raimondi L., Raimondo S., Siragusa S., Urzi O.   +10 more
core   +1 more source