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Regulation of Osteoblast Differentiation by Slit2 in Osteoblastic Cells
Cells Tissues Organs, 2008<i>Background/Aims:</i> There is an urgent need to identify the molecular factors involved in osteoblast proliferation and differentiation in order to improve bone formation and treat bone disease. Recent studies demonstrate that many ‘axon guidance’ molecules play important roles in the development and remodeling of bone through their ...
Hongli, Sun +3 more
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2011
This chapter describes the isolation, culture and staining of primary osteoblasts from the calvaria and long bones of neonatal rats. The key advantages of this assay are that it allows direct measurement of bone matrix deposition and mineralisation, as well as yielding good quantities of osteoblasts at defined stages of differentiation for molecular ...
Isabel R, Orriss +2 more
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This chapter describes the isolation, culture and staining of primary osteoblasts from the calvaria and long bones of neonatal rats. The key advantages of this assay are that it allows direct measurement of bone matrix deposition and mineralisation, as well as yielding good quantities of osteoblasts at defined stages of differentiation for molecular ...
Isabel R, Orriss +2 more
openaire +2 more sources
Regulation of Osteoblast Activity and the Osteoblast-Osteocyte Transformation
1982According to currently held concepts of bone formation (Table 1), osteoblasts develop from mitotically competent marrow stromal cells by a process of non-mitotic differentiation (modulation) (1,2). Osteoblasts are attracted to the bone surfaces, and are activated to elaborate lamellae of collagen-rich organic matrix (osteoid) which is subsequently ...
W A, Peck, L, Rifas
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2013
Bone formation takes place throughout life in order to support growth, mechanical forces, bone turnover to meet metabolic needs, and the reparative process. The requirement for continuous renewal of bone through the remodeling process necessitates recruitment, proliferation, and differentiation of osteoblast-lineage cells. A contributing factor to bone
van Leeuwen, Johannes P.T.M. +4 more
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Bone formation takes place throughout life in order to support growth, mechanical forces, bone turnover to meet metabolic needs, and the reparative process. The requirement for continuous renewal of bone through the remodeling process necessitates recruitment, proliferation, and differentiation of osteoblast-lineage cells. A contributing factor to bone
van Leeuwen, Johannes P.T.M. +4 more
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Ciba Foundation symposium, 1989
The fully differentiated osteoblast may be easily recognized in bone tissue. Its cuboidal shape, its position directly opposed to the bone surface and its capacity to produce calcified bone matrix are characteristic. Three other differentiation stages are also reasonably well defined--the preosteoblast, the osteocyte and the lining cell.
P J, Nijweide +2 more
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The fully differentiated osteoblast may be easily recognized in bone tissue. Its cuboidal shape, its position directly opposed to the bone surface and its capacity to produce calcified bone matrix are characteristic. Three other differentiation stages are also reasonably well defined--the preosteoblast, the osteocyte and the lining cell.
P J, Nijweide +2 more
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Serious games have become an essential educational tool for teaching human anatomy by fostering active learning and improving knowledge retention. Traditional methods often rely on rote memorization, making it challenging for students to engage with complex anatomical structures.
Víctor Ernesto Moreno González +4 more
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Víctor Ernesto Moreno González +4 more
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Novel approaches to target the microenvironment of bone metastasis
Nature Reviews Clinical Oncology, 2021Lorenz C Hofbauer +2 more
exaly